Dietary iodine attenuates allergic rhinitis by inducing ferroptosis in activated B cells
Abstract Iodine-containing formulations have been widely used to treat iodine deficiency and as antiseptics. Lecithin-bound iodine (LBI) has been approved to treat allergic diseases in Japan; however, its underlying mechanism remains unknown. In this study, we show that LBI ameliorated disease sympt...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-04-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-32552-1 |
| _version_ | 1797850037113323520 |
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| author | Yutaka Nakamura Yozen Fuse Seiga Komiyama Takahiro Nagatake Jun Kunisawa Koji Hase |
| author_facet | Yutaka Nakamura Yozen Fuse Seiga Komiyama Takahiro Nagatake Jun Kunisawa Koji Hase |
| author_sort | Yutaka Nakamura |
| collection | DOAJ |
| description | Abstract Iodine-containing formulations have been widely used to treat iodine deficiency and as antiseptics. Lecithin-bound iodine (LBI) has been approved to treat allergic diseases in Japan; however, its underlying mechanism remains unknown. In this study, we show that LBI ameliorated disease symptoms in an ovalbumin (OVA)-induced allergic rhinitis mouse model. LBI suppressed OVA-specific IgE production by attenuating germinal center (GC) reaction in the draining lymph nodes. The antiallergic effect of LBI is most likely attributed to increased serum iodine levels but not thyroid hormone levels. In vitro treatment of activated B cells with potassium iodide induced ferroptosis by increasing intracellular reactive oxygen species (ROS) and ferrous iron in a concentration-dependent manner. Accordingly, LBI diets increased ROS levels in GC B cells of the draining lymph nodes. This study suggests that iodine directly promotes ferroptosis in activated B cells and attenuates GC reactions, leading to the alleviation of allergic symptoms. |
| first_indexed | 2024-04-09T18:54:56Z |
| format | Article |
| id | doaj.art-75cad2e71dff494dbe216b44cb6a3716 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-09T18:54:56Z |
| publishDate | 2023-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-75cad2e71dff494dbe216b44cb6a37162023-04-09T11:15:21ZengNature PortfolioScientific Reports2045-23222023-04-0113111210.1038/s41598-023-32552-1Dietary iodine attenuates allergic rhinitis by inducing ferroptosis in activated B cellsYutaka Nakamura0Yozen Fuse1Seiga Komiyama2Takahiro Nagatake3Jun Kunisawa4Koji Hase5Division of Biochemistry, Faculty of Pharmaceutical Science, Keio UniversityResearch Committee on Iodine-Related Health Problems, Foundation for Growth ScienceDivision of Biochemistry, Faculty of Pharmaceutical Science, Keio UniversityLaboratory of Functional Anatomy, Department of Life Sciences, School of Agriculture, Meiji UniversityLaboratory of Vaccine Materials, Center for Vaccine and Adjuvant Research and Laboratory of Gut Environmental System, Collaborative Research Center for Health and Medicine, National Institutes of Biomedical Innovation, Health and NutritionDivision of Biochemistry, Faculty of Pharmaceutical Science, Keio UniversityAbstract Iodine-containing formulations have been widely used to treat iodine deficiency and as antiseptics. Lecithin-bound iodine (LBI) has been approved to treat allergic diseases in Japan; however, its underlying mechanism remains unknown. In this study, we show that LBI ameliorated disease symptoms in an ovalbumin (OVA)-induced allergic rhinitis mouse model. LBI suppressed OVA-specific IgE production by attenuating germinal center (GC) reaction in the draining lymph nodes. The antiallergic effect of LBI is most likely attributed to increased serum iodine levels but not thyroid hormone levels. In vitro treatment of activated B cells with potassium iodide induced ferroptosis by increasing intracellular reactive oxygen species (ROS) and ferrous iron in a concentration-dependent manner. Accordingly, LBI diets increased ROS levels in GC B cells of the draining lymph nodes. This study suggests that iodine directly promotes ferroptosis in activated B cells and attenuates GC reactions, leading to the alleviation of allergic symptoms.https://doi.org/10.1038/s41598-023-32552-1 |
| spellingShingle | Yutaka Nakamura Yozen Fuse Seiga Komiyama Takahiro Nagatake Jun Kunisawa Koji Hase Dietary iodine attenuates allergic rhinitis by inducing ferroptosis in activated B cells Scientific Reports |
| title | Dietary iodine attenuates allergic rhinitis by inducing ferroptosis in activated B cells |
| title_full | Dietary iodine attenuates allergic rhinitis by inducing ferroptosis in activated B cells |
| title_fullStr | Dietary iodine attenuates allergic rhinitis by inducing ferroptosis in activated B cells |
| title_full_unstemmed | Dietary iodine attenuates allergic rhinitis by inducing ferroptosis in activated B cells |
| title_short | Dietary iodine attenuates allergic rhinitis by inducing ferroptosis in activated B cells |
| title_sort | dietary iodine attenuates allergic rhinitis by inducing ferroptosis in activated b cells |
| url | https://doi.org/10.1038/s41598-023-32552-1 |
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