Ultrasound-guided percutaneous microwave ablation versus surgical resection for recurrent intrahepatic cholangiocarcinoma: intermediate-term results
Objective: The aims of this study were to compare the clinical outcomes between ultrasound-guided percutaneous microwave ablation (US-PMWA) and surgical resection (SR) in patients with recurrent intrahepatic cholangiocarcinoma (ICC) and to identify the prognostic factors associated with the two trea...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2019-01-01
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| Series: | International Journal of Hyperthermia |
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| Online Access: | http://dx.doi.org/10.1080/02656736.2019.1571247 |
| _version_ | 1818303479053025280 |
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| author | Chuanjun Xu Lei Li Wei Xu Chao Du Lixin Yang Jinlong Tong Yongxiang Yi |
| author_facet | Chuanjun Xu Lei Li Wei Xu Chao Du Lixin Yang Jinlong Tong Yongxiang Yi |
| author_sort | Chuanjun Xu |
| collection | DOAJ |
| description | Objective: The aims of this study were to compare the clinical outcomes between ultrasound-guided percutaneous microwave ablation (US-PMWA) and surgical resection (SR) in patients with recurrent intrahepatic cholangiocarcinoma (ICC) and to identify the prognostic factors associated with the two treatment methods. Methods: This retrospective study was institutional review board approved. A total of 121 patients (102 men and 19 women) with 136 ICCs after hepatectomy from April 2011 to January 2017 were reviewed. Fifty-six patients underwent US-PMWA and 65 patients underwent SR. Survival, recurrence and liver function were compared between the two groups. Effect of changes in key parameters [i.e., overall survival (OS) and recurrence-free survival (RFS)] was statistically analyzed with the log-rank test. Univariate and multivariate analysis were performed on clinicopathological variables to identify factors affecting long-term outcome. Results: The OS and RFS after MWA were comparable to that of SR (p = .405, and p = .589, respectively). Estimated 5-year OS rates were 23.7% after MWA and 21.8% after SR; for RFS, estimated 3-year RFS rates were 33.1% after MWA and 30.6% after SR. Major complication rates in SR group were higher than that in MWA (p < .001) (SR, 13.8% vs. MWA, 5.3%). Multivariate analysis showed tumor number (p = .012), ALBI grade (p = .007), and metastasis (p = .016), may become OS rate predictors. Conclusions: US-PMWA had comparable oncologic outcomes with SR and could be a safe and effective treatment for recurrent ICC after hepatectomy. |
| first_indexed | 2024-12-13T05:55:27Z |
| format | Article |
| id | doaj.art-75cbd3ab8ee14578b580f73da68a4aca |
| institution | Directory Open Access Journal |
| issn | 0265-6736 1464-5157 |
| language | English |
| last_indexed | 2024-12-13T05:55:27Z |
| publishDate | 2019-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | International Journal of Hyperthermia |
| spelling | doaj.art-75cbd3ab8ee14578b580f73da68a4aca2022-12-21T23:57:26ZengTaylor & Francis GroupInternational Journal of Hyperthermia0265-67361464-51572019-01-0136135035710.1080/02656736.2019.15712471571247Ultrasound-guided percutaneous microwave ablation versus surgical resection for recurrent intrahepatic cholangiocarcinoma: intermediate-term resultsChuanjun Xu0Lei Li1Wei Xu2Chao Du3Lixin Yang4Jinlong Tong5Yongxiang Yi6The Second Hospital of Nanjing Nanjing University of Chinese MedicineThe Affiliated Central Hospital of Qingdao UniversityThe Affiliated Central Hospital of Qingdao UniversityThe Second Hospital of Nanjing Nanjing University of Chinese MedicineThe Second Hospital of Nanjing Nanjing University of Chinese MedicineThe Second Hospital of Nanjing Nanjing University of Chinese MedicineThe Second Hospital of Nanjing Nanjing University of Chinese MedicineObjective: The aims of this study were to compare the clinical outcomes between ultrasound-guided percutaneous microwave ablation (US-PMWA) and surgical resection (SR) in patients with recurrent intrahepatic cholangiocarcinoma (ICC) and to identify the prognostic factors associated with the two treatment methods. Methods: This retrospective study was institutional review board approved. A total of 121 patients (102 men and 19 women) with 136 ICCs after hepatectomy from April 2011 to January 2017 were reviewed. Fifty-six patients underwent US-PMWA and 65 patients underwent SR. Survival, recurrence and liver function were compared between the two groups. Effect of changes in key parameters [i.e., overall survival (OS) and recurrence-free survival (RFS)] was statistically analyzed with the log-rank test. Univariate and multivariate analysis were performed on clinicopathological variables to identify factors affecting long-term outcome. Results: The OS and RFS after MWA were comparable to that of SR (p = .405, and p = .589, respectively). Estimated 5-year OS rates were 23.7% after MWA and 21.8% after SR; for RFS, estimated 3-year RFS rates were 33.1% after MWA and 30.6% after SR. Major complication rates in SR group were higher than that in MWA (p < .001) (SR, 13.8% vs. MWA, 5.3%). Multivariate analysis showed tumor number (p = .012), ALBI grade (p = .007), and metastasis (p = .016), may become OS rate predictors. Conclusions: US-PMWA had comparable oncologic outcomes with SR and could be a safe and effective treatment for recurrent ICC after hepatectomy.http://dx.doi.org/10.1080/02656736.2019.1571247intrahepatic cholangiocarcinomamicrowave ablationsurgical resectionpercutaneousultrasound-guided |
| spellingShingle | Chuanjun Xu Lei Li Wei Xu Chao Du Lixin Yang Jinlong Tong Yongxiang Yi Ultrasound-guided percutaneous microwave ablation versus surgical resection for recurrent intrahepatic cholangiocarcinoma: intermediate-term results International Journal of Hyperthermia intrahepatic cholangiocarcinoma microwave ablation surgical resection percutaneous ultrasound-guided |
| title | Ultrasound-guided percutaneous microwave ablation versus surgical resection for recurrent intrahepatic cholangiocarcinoma: intermediate-term results |
| title_full | Ultrasound-guided percutaneous microwave ablation versus surgical resection for recurrent intrahepatic cholangiocarcinoma: intermediate-term results |
| title_fullStr | Ultrasound-guided percutaneous microwave ablation versus surgical resection for recurrent intrahepatic cholangiocarcinoma: intermediate-term results |
| title_full_unstemmed | Ultrasound-guided percutaneous microwave ablation versus surgical resection for recurrent intrahepatic cholangiocarcinoma: intermediate-term results |
| title_short | Ultrasound-guided percutaneous microwave ablation versus surgical resection for recurrent intrahepatic cholangiocarcinoma: intermediate-term results |
| title_sort | ultrasound guided percutaneous microwave ablation versus surgical resection for recurrent intrahepatic cholangiocarcinoma intermediate term results |
| topic | intrahepatic cholangiocarcinoma microwave ablation surgical resection percutaneous ultrasound-guided |
| url | http://dx.doi.org/10.1080/02656736.2019.1571247 |
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