Gut microbiota, microbiota‐derived metabolites, and graft‐versus‐host disease
Abstract Allogeneic hematopoietic stem cell transplantation is one of the most effective treatment strategies for leukemia, lymphoma, and other hematologic malignancies. However, graft‐versus‐host disease (GVHD) can significantly reduce the survival rate and quality of life of patients after transpl...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2024-02-01
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| Series: | Cancer Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/cam4.6799 |
| _version_ | 1797216978243420160 |
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| author | XiaoYan Yue Hongyu Zhou ShuFen Wang Xu Chen HaoWen Xiao |
| author_facet | XiaoYan Yue Hongyu Zhou ShuFen Wang Xu Chen HaoWen Xiao |
| author_sort | XiaoYan Yue |
| collection | DOAJ |
| description | Abstract Allogeneic hematopoietic stem cell transplantation is one of the most effective treatment strategies for leukemia, lymphoma, and other hematologic malignancies. However, graft‐versus‐host disease (GVHD) can significantly reduce the survival rate and quality of life of patients after transplantation, and is therefore the greatest obstacle to transplantation. The recent development of new technologies, including high‐throughput sequencing, metabolomics, and others, has facilitated great progress in understanding the complex interactions between gut microbiota, microbiota‐derived metabolites, and the host. Of these interactions, the relationship between gut microbiota, microbial‐associated metabolites, and GVHD has been most intensively researched. Studies have shown that GVHD patients often suffer from gut microbiota dysbiosis, which mainly manifests as decreased microbial diversity and changes in microbial composition and microbiota‐derived metabolites, both of which are significant predictors of poor prognosis in GVHD patients. Therefore, the purpose of this review is to summarize what is known regarding changes in gut microbiota and microbiota‐derived metabolites in GVHD, their relationship to GVHD prognosis, and corresponding clinical strategies designed to prevent microbial dysregulation and facilitate treatment of GVHD. |
| first_indexed | 2024-03-07T15:43:39Z |
| format | Article |
| id | doaj.art-75cd0637f2be4621b05debe891e98534 |
| institution | Directory Open Access Journal |
| issn | 2045-7634 |
| language | English |
| last_indexed | 2024-04-24T11:54:33Z |
| publishDate | 2024-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj.art-75cd0637f2be4621b05debe891e985342024-04-09T05:45:48ZengWileyCancer Medicine2045-76342024-02-01133n/an/a10.1002/cam4.6799Gut microbiota, microbiota‐derived metabolites, and graft‐versus‐host diseaseXiaoYan Yue0Hongyu Zhou1ShuFen Wang2Xu Chen3HaoWen Xiao4Department of Hematology, Sir Run Run Shaw Hospital Zhejiang University School of Medicine Hangzhou ChinaDepartment of Hematology, Sir Run Run Shaw Hospital Zhejiang University School of Medicine Hangzhou ChinaDepartment of Hematology, Sir Run Run Shaw Hospital Zhejiang University School of Medicine Hangzhou ChinaDepartment of Hematology, Sir Run Run Shaw Hospital Zhejiang University School of Medicine Hangzhou ChinaDepartment of Hematology, Sir Run Run Shaw Hospital Zhejiang University School of Medicine Hangzhou ChinaAbstract Allogeneic hematopoietic stem cell transplantation is one of the most effective treatment strategies for leukemia, lymphoma, and other hematologic malignancies. However, graft‐versus‐host disease (GVHD) can significantly reduce the survival rate and quality of life of patients after transplantation, and is therefore the greatest obstacle to transplantation. The recent development of new technologies, including high‐throughput sequencing, metabolomics, and others, has facilitated great progress in understanding the complex interactions between gut microbiota, microbiota‐derived metabolites, and the host. Of these interactions, the relationship between gut microbiota, microbial‐associated metabolites, and GVHD has been most intensively researched. Studies have shown that GVHD patients often suffer from gut microbiota dysbiosis, which mainly manifests as decreased microbial diversity and changes in microbial composition and microbiota‐derived metabolites, both of which are significant predictors of poor prognosis in GVHD patients. Therefore, the purpose of this review is to summarize what is known regarding changes in gut microbiota and microbiota‐derived metabolites in GVHD, their relationship to GVHD prognosis, and corresponding clinical strategies designed to prevent microbial dysregulation and facilitate treatment of GVHD.https://doi.org/10.1002/cam4.6799allogeneic hematopoietic stem cell transplantationgraft‐versus‐host diseasegut microbiotamicrobiota‐derived metabolites |
| spellingShingle | XiaoYan Yue Hongyu Zhou ShuFen Wang Xu Chen HaoWen Xiao Gut microbiota, microbiota‐derived metabolites, and graft‐versus‐host disease Cancer Medicine allogeneic hematopoietic stem cell transplantation graft‐versus‐host disease gut microbiota microbiota‐derived metabolites |
| title | Gut microbiota, microbiota‐derived metabolites, and graft‐versus‐host disease |
| title_full | Gut microbiota, microbiota‐derived metabolites, and graft‐versus‐host disease |
| title_fullStr | Gut microbiota, microbiota‐derived metabolites, and graft‐versus‐host disease |
| title_full_unstemmed | Gut microbiota, microbiota‐derived metabolites, and graft‐versus‐host disease |
| title_short | Gut microbiota, microbiota‐derived metabolites, and graft‐versus‐host disease |
| title_sort | gut microbiota microbiota derived metabolites and graft versus host disease |
| topic | allogeneic hematopoietic stem cell transplantation graft‐versus‐host disease gut microbiota microbiota‐derived metabolites |
| url | https://doi.org/10.1002/cam4.6799 |
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