Effects of Age on Long-Term Functional Recovery in Patients with Stroke

<i>Background and objectives:</i> Age might be a determinant that limits functional recovery in patients with stroke. Here, we investigated the effect of age on functional recovery within 30 months after stroke onset. <i>Materials and Methods:</i> This retrospective longitudi...

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Bibliographic Details
Main Authors: Jae Wan Yoo, Bo Young Hong, Leechan Jo, Joon-Sung Kim, Jung Geun Park, Bo Kyung Shin, Seong Hoon Lim
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Medicina
Subjects:
Online Access:https://www.mdpi.com/1010-660X/56/9/451
Description
Summary:<i>Background and objectives:</i> Age might be a determinant that limits functional recovery in patients with stroke. Here, we investigated the effect of age on functional recovery within 30 months after stroke onset. <i>Materials and Methods:</i> This retrospective longitudinal study enrolled 111 patients with first-ever stroke. Functional recovery was assessed at 2 weeks and at 1, 6, and 30 months after stroke onset using the modified Barthel Index (MBI), modified Rankin Score (mRS), functional ambulation category (FAC), muscle strength, and Mini-Mental State Examination (MMSE). A generalized estimating equation analysis was performed. <i>Results:</i> With the MBI, function improved until 6 months after stroke onset in patients aged <70 years and until 1 month after stroke onset in patients ≥70 years. At 30 months after stroke, there was no significant change of MBI in patients aged <70 years, whereas there was a significant decline in older patients. With the mRS and FAC, function improved until 30 months after stroke onset in patients aged <70 years and until 1 month after stroke onset in older patients. Motor deficit, assessed using the Medical Research Council (MRC), improved significantly until 6 months after stroke onset in patients aged <70 years. There was a significant improvement in cognition (assessed using the MMSE) until 6 months after stroke onset in patients aged <70 years and until 1 month after stroke onset in older patients. <i>Conclusions:</i> Long-term functional recovery occurred for up to 30 months after stroke. Patients aged ≥70 years showed functional decline between 6 and 30 months after onset. These findings could be useful when measuring functional recovery after stroke.
ISSN:1010-660X