Elevated Systemic and Intestinal Inflammatory Response Are Associated With Gut Microbiome Disorder After Cardiovascular Surgery
Systemic inflammatory response after cardiovascular surgery is associated with poor prognosis, to which gut barrier impairment is related. To investigate whether perioperative changes of the gut microbiome are associated with systemic and intestinal inflammatory response, we examined changes of the...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-08-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2021.686648/full |
| _version_ | 1819118368794345472 |
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| author | Xiong Xia Jiangjin Ni Shengnan Yin Zhipeng Yang Haini Jiang Chao Wang Jian Peng Hongkui Wei Xingyu Wang |
| author_facet | Xiong Xia Jiangjin Ni Shengnan Yin Zhipeng Yang Haini Jiang Chao Wang Jian Peng Hongkui Wei Xingyu Wang |
| author_sort | Xiong Xia |
| collection | DOAJ |
| description | Systemic inflammatory response after cardiovascular surgery is associated with poor prognosis, to which gut barrier impairment is related. To investigate whether perioperative changes of the gut microbiome are associated with systemic and intestinal inflammatory response, we examined changes of the gut microbiome, intestinal homeostasis, and systemic inflammatory response in cardiovascular patients before (Pre) surgery and on the first defecation day [postoperative time 1 (Po1)] or a week [postoperative time 2 (Po2)] postsurgery. Markedly, the enhanced systemic inflammatory response was observed in Po1 and Po2 compared with that in Pre. In line with inflammatory response, impaired gut barrier and elevated gut local inflammation were observed in Po1 and Po2. Microbiome analysis showed a remarkable and steady decline of alpha diversity perioperatively. In addition, microbial composition in the postoperation period was characterized by significant expansion of Enterococcus along with a decrease in anaerobes (Blautia, Faecalibacterium, Bifidobacterium, Roseburia, Gemmiger, [Ruminococcus], and Coprococcus), which were typically health-associated bacteria. Spearman correlation analysis showed microbiome disorder was associated with enhanced systemic inflammatory response and intestinal dysbiosis. These results suggest that microbiome disorder was related to disturbed gut homeostatic and subsequently elevates plasma endotoxin and systemic inflammatory response after cardiovascular surgery. This study not only highlights gut microbiome would be considered in future clinical practice but also proposes a promising perspective of potential diagnostic and therapeutic options for perioperative management of cardiovascular surgery patients. |
| first_indexed | 2024-12-22T05:47:46Z |
| format | Article |
| id | doaj.art-75ced4bbba0b498b977a4db314c1c08f |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-12-22T05:47:46Z |
| publishDate | 2021-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-75ced4bbba0b498b977a4db314c1c08f2022-12-21T18:36:58ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2021-08-011210.3389/fmicb.2021.686648686648Elevated Systemic and Intestinal Inflammatory Response Are Associated With Gut Microbiome Disorder After Cardiovascular SurgeryXiong Xia0Jiangjin Ni1Shengnan Yin2Zhipeng Yang3Haini Jiang4Chao Wang5Jian Peng6Hongkui Wei7Xingyu Wang8Department of Animal Nutrition and Feed Science, College of Animal Science, Huazhong Agricultural University, Wuhan, ChinaDepartment of Animal Nutrition and Feed Science, College of Animal Science, Huazhong Agricultural University, Wuhan, ChinaDepartment of Animal Nutrition and Feed Science, College of Animal Science, Huazhong Agricultural University, Wuhan, ChinaDepartment of Animal Nutrition and Feed Science, College of Animal Science, Huazhong Agricultural University, Wuhan, ChinaMedical Affairs Office, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Animal Nutrition and Feed Science, College of Animal Science, Huazhong Agricultural University, Wuhan, ChinaDepartment of Animal Nutrition and Feed Science, College of Animal Science, Huazhong Agricultural University, Wuhan, ChinaDepartment of Animal Nutrition and Feed Science, College of Animal Science, Huazhong Agricultural University, Wuhan, ChinaDivision of Cardiothoracic and Vascular Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaSystemic inflammatory response after cardiovascular surgery is associated with poor prognosis, to which gut barrier impairment is related. To investigate whether perioperative changes of the gut microbiome are associated with systemic and intestinal inflammatory response, we examined changes of the gut microbiome, intestinal homeostasis, and systemic inflammatory response in cardiovascular patients before (Pre) surgery and on the first defecation day [postoperative time 1 (Po1)] or a week [postoperative time 2 (Po2)] postsurgery. Markedly, the enhanced systemic inflammatory response was observed in Po1 and Po2 compared with that in Pre. In line with inflammatory response, impaired gut barrier and elevated gut local inflammation were observed in Po1 and Po2. Microbiome analysis showed a remarkable and steady decline of alpha diversity perioperatively. In addition, microbial composition in the postoperation period was characterized by significant expansion of Enterococcus along with a decrease in anaerobes (Blautia, Faecalibacterium, Bifidobacterium, Roseburia, Gemmiger, [Ruminococcus], and Coprococcus), which were typically health-associated bacteria. Spearman correlation analysis showed microbiome disorder was associated with enhanced systemic inflammatory response and intestinal dysbiosis. These results suggest that microbiome disorder was related to disturbed gut homeostatic and subsequently elevates plasma endotoxin and systemic inflammatory response after cardiovascular surgery. This study not only highlights gut microbiome would be considered in future clinical practice but also proposes a promising perspective of potential diagnostic and therapeutic options for perioperative management of cardiovascular surgery patients.https://www.frontiersin.org/articles/10.3389/fmicb.2021.686648/fullcardiovascular diseasesperioperationgut microbiomesystemic inflammatory responsegut barriergut local inflammation |
| spellingShingle | Xiong Xia Jiangjin Ni Shengnan Yin Zhipeng Yang Haini Jiang Chao Wang Jian Peng Hongkui Wei Xingyu Wang Elevated Systemic and Intestinal Inflammatory Response Are Associated With Gut Microbiome Disorder After Cardiovascular Surgery Frontiers in Microbiology cardiovascular diseases perioperation gut microbiome systemic inflammatory response gut barrier gut local inflammation |
| title | Elevated Systemic and Intestinal Inflammatory Response Are Associated With Gut Microbiome Disorder After Cardiovascular Surgery |
| title_full | Elevated Systemic and Intestinal Inflammatory Response Are Associated With Gut Microbiome Disorder After Cardiovascular Surgery |
| title_fullStr | Elevated Systemic and Intestinal Inflammatory Response Are Associated With Gut Microbiome Disorder After Cardiovascular Surgery |
| title_full_unstemmed | Elevated Systemic and Intestinal Inflammatory Response Are Associated With Gut Microbiome Disorder After Cardiovascular Surgery |
| title_short | Elevated Systemic and Intestinal Inflammatory Response Are Associated With Gut Microbiome Disorder After Cardiovascular Surgery |
| title_sort | elevated systemic and intestinal inflammatory response are associated with gut microbiome disorder after cardiovascular surgery |
| topic | cardiovascular diseases perioperation gut microbiome systemic inflammatory response gut barrier gut local inflammation |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2021.686648/full |
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