Older Patients on Hemodiafiltration: Behavior of Uremic Toxins, Inflammation, Endothelium, and Bone Mineral Disorder
Chronic kidney disease (CKD) affects 10% of the world’s population. Uremic toxins, such as indoxyl sulfate (IS), p-Cresylsulfate (PCS) and indole acetic acid (IAA), are not sufficiently removed by conventional hemodialysis (HD) and have been associated with inflammation, poor quality of life, bone m...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | International Journal of Translational Medicine |
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| Online Access: | https://www.mdpi.com/2673-8937/2/3/31 |
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| author | Armando Morales-Jr Walter Pereira Pinto Vanessa Correa Fanchini Luana Cristina de Almeida Silva Thiago José Martins Gonçalves Pamela Nithzi Bricher Choque Fernanda Kussi Lia Sumie Nakao Rosilene Motta Elias Maria Aparecida Dalboni |
| author_facet | Armando Morales-Jr Walter Pereira Pinto Vanessa Correa Fanchini Luana Cristina de Almeida Silva Thiago José Martins Gonçalves Pamela Nithzi Bricher Choque Fernanda Kussi Lia Sumie Nakao Rosilene Motta Elias Maria Aparecida Dalboni |
| author_sort | Armando Morales-Jr |
| collection | DOAJ |
| description | Chronic kidney disease (CKD) affects 10% of the world’s population. Uremic toxins, such as indoxyl sulfate (IS), p-Cresylsulfate (PCS) and indole acetic acid (IAA), are not sufficiently removed by conventional hemodialysis (HD) and have been associated with inflammation, poor quality of life, bone mineral disease (BMD) and endothelial injury. Online hemodiafiltration (OL-HDF) may promote greater clearance of uremic toxins than HD. However, there are few studies evaluating the effect of OL-HDF on serum levels of IS, PCS, IAA, and biomarkers associated with inflammatory, endothelial, and bone and mineral disorder in the elderly population. We evaluated the effect of 6 months of OL-HDF on the serum concentration of uremic toxins, biomarkers of inflammation, endothelial and bone mineral disorder in older patients on OL-HDF. IS, PCS, and IAA were measured by high-performance liquid chromatography. We included 31 patients (77.4 ± 7.1 years, 64.5% male, 35.5% diabetic, on maintenance dialysis for 45 ± 20 days). From baseline to 6 months there was a decrease in serum concentration of IS but not PCS and IAA. We found no change in serum concentration of inflammatory, endothelial, or mineral and bone biomarkers. In summary, OL-HDF was capable to reduce IS in older patients. Whether this reduction may have an impact on clinical outcomes deserves further evaluation. |
| first_indexed | 2024-03-09T23:40:57Z |
| format | Article |
| id | doaj.art-75d1c4206172486db5ea872da6f89b7d |
| institution | Directory Open Access Journal |
| issn | 2673-8937 |
| language | English |
| last_indexed | 2024-03-09T23:40:57Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Translational Medicine |
| spelling | doaj.art-75d1c4206172486db5ea872da6f89b7d2023-11-23T16:52:16ZengMDPI AGInternational Journal of Translational Medicine2673-89372022-08-012339840710.3390/ijtm2030031Older Patients on Hemodiafiltration: Behavior of Uremic Toxins, Inflammation, Endothelium, and Bone Mineral DisorderArmando Morales-Jr0Walter Pereira Pinto1Vanessa Correa Fanchini2Luana Cristina de Almeida Silva3Thiago José Martins Gonçalves4Pamela Nithzi Bricher Choque5Fernanda Kussi6Lia Sumie Nakao7Rosilene Motta Elias8Maria Aparecida Dalboni9Department of Postgraduate in Medicine, Universidade Nove de Julho (UNINOVE), Sao Paulo 01000-000, BrazilDepartment of Postgraduate in Medicine, Universidade Nove de Julho (UNINOVE), Sao Paulo 01000-000, BrazilDepartment of Postgraduate in Medicine, Universidade Nove de Julho (UNINOVE), Sao Paulo 01000-000, BrazilDepartment of Postgraduate in Medicine, Universidade Nove de Julho (UNINOVE), Sao Paulo 01000-000, BrazilDepartment of Postgraduate in Medicine, Universidade Nove de Julho (UNINOVE), Sao Paulo 01000-000, BrazilDepartment of Postgraduate in Medicine, Universidade Nove de Julho (UNINOVE), Sao Paulo 01000-000, BrazilDepartament of Basic Pathology, Universidade Federal do Paraná, Curitiba 80000-000, BrazilDepartament of Basic Pathology, Universidade Federal do Paraná, Curitiba 80000-000, BrazilDepartment of Postgraduate in Medicine, Universidade Nove de Julho (UNINOVE), Sao Paulo 01000-000, BrazilDepartment of Postgraduate in Medicine, Universidade Nove de Julho (UNINOVE), Sao Paulo 01000-000, BrazilChronic kidney disease (CKD) affects 10% of the world’s population. Uremic toxins, such as indoxyl sulfate (IS), p-Cresylsulfate (PCS) and indole acetic acid (IAA), are not sufficiently removed by conventional hemodialysis (HD) and have been associated with inflammation, poor quality of life, bone mineral disease (BMD) and endothelial injury. Online hemodiafiltration (OL-HDF) may promote greater clearance of uremic toxins than HD. However, there are few studies evaluating the effect of OL-HDF on serum levels of IS, PCS, IAA, and biomarkers associated with inflammatory, endothelial, and bone and mineral disorder in the elderly population. We evaluated the effect of 6 months of OL-HDF on the serum concentration of uremic toxins, biomarkers of inflammation, endothelial and bone mineral disorder in older patients on OL-HDF. IS, PCS, and IAA were measured by high-performance liquid chromatography. We included 31 patients (77.4 ± 7.1 years, 64.5% male, 35.5% diabetic, on maintenance dialysis for 45 ± 20 days). From baseline to 6 months there was a decrease in serum concentration of IS but not PCS and IAA. We found no change in serum concentration of inflammatory, endothelial, or mineral and bone biomarkers. In summary, OL-HDF was capable to reduce IS in older patients. Whether this reduction may have an impact on clinical outcomes deserves further evaluation.https://www.mdpi.com/2673-8937/2/3/31chronic kidney diseasehemodiafiltrationuremic toxinsbiomarkersinflammationendothelium |
| spellingShingle | Armando Morales-Jr Walter Pereira Pinto Vanessa Correa Fanchini Luana Cristina de Almeida Silva Thiago José Martins Gonçalves Pamela Nithzi Bricher Choque Fernanda Kussi Lia Sumie Nakao Rosilene Motta Elias Maria Aparecida Dalboni Older Patients on Hemodiafiltration: Behavior of Uremic Toxins, Inflammation, Endothelium, and Bone Mineral Disorder International Journal of Translational Medicine chronic kidney disease hemodiafiltration uremic toxins biomarkers inflammation endothelium |
| title | Older Patients on Hemodiafiltration: Behavior of Uremic Toxins, Inflammation, Endothelium, and Bone Mineral Disorder |
| title_full | Older Patients on Hemodiafiltration: Behavior of Uremic Toxins, Inflammation, Endothelium, and Bone Mineral Disorder |
| title_fullStr | Older Patients on Hemodiafiltration: Behavior of Uremic Toxins, Inflammation, Endothelium, and Bone Mineral Disorder |
| title_full_unstemmed | Older Patients on Hemodiafiltration: Behavior of Uremic Toxins, Inflammation, Endothelium, and Bone Mineral Disorder |
| title_short | Older Patients on Hemodiafiltration: Behavior of Uremic Toxins, Inflammation, Endothelium, and Bone Mineral Disorder |
| title_sort | older patients on hemodiafiltration behavior of uremic toxins inflammation endothelium and bone mineral disorder |
| topic | chronic kidney disease hemodiafiltration uremic toxins biomarkers inflammation endothelium |
| url | https://www.mdpi.com/2673-8937/2/3/31 |
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