Primary breast lymphomas
The diagnosis, prognostic factors, and optimal management of primary breast lymphomas (PBL) is difficult. Seven patients recorded at the Geneva Cancer Registry between 1973-1998 were reviewed. Five patient had diffuse large B-cell lymphoma, one a follicular lymphoma and one a MALT-lymphoma. All pati...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2009-07-01
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| Series: | Rare Tumors |
| Subjects: | |
| Online Access: | http://www.pagepress.org/journals/index.php/rt/article/view/1015 |
| _version_ | 1828880185012781056 |
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| author | Anne-Thérèse Vlastos Jean-Bernard Dubuisson Georges Vlastos Federica Capanna Christine Bouchardy Marie Françoise Pelte Olivier Julen Ilaria Dellacasa |
| author_facet | Anne-Thérèse Vlastos Jean-Bernard Dubuisson Georges Vlastos Federica Capanna Christine Bouchardy Marie Françoise Pelte Olivier Julen Ilaria Dellacasa |
| author_sort | Anne-Thérèse Vlastos |
| collection | DOAJ |
| description | The diagnosis, prognostic factors, and optimal management of primary breast lymphomas (PBL) is difficult. Seven patients recorded at the Geneva Cancer Registry between 1973-1998 were reviewed. Five patient had diffuse large B-cell lymphoma, one a follicular lymphoma and one a MALT-lymphoma. All patients had clinical and radiological findings consistent with breast cancer and underwent mastectomy, which is not indicated in PBL. Diagnosis should be established prior to operative interventions, as fine needle aspiration missed the diagnosis for one patient and intra-operative frozen sections for 3 patients in our study. Five-year and 10-year overall survivals were 57% and 15%, respectively. Of the 3 patients who died from PBL, 2 had tumors that were Bcl-2 positive but Bcl-6 negative. All 3 surviving patients have positive Bcl-2 and Bcl-6 immunostaining, which could be important prognostic factors if confirmed by a larger study. |
| first_indexed | 2024-12-13T09:42:48Z |
| format | Article |
| id | doaj.art-75d32d937e334276ab2479b7ae3a25e7 |
| institution | Directory Open Access Journal |
| issn | 2036-3605 2036-3613 |
| language | English |
| last_indexed | 2024-12-13T09:42:48Z |
| publishDate | 2009-07-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Rare Tumors |
| spelling | doaj.art-75d32d937e334276ab2479b7ae3a25e72022-12-21T23:52:08ZengSAGE PublishingRare Tumors2036-36052036-36132009-07-0111e14e1410.4081/rt.2009.e14Primary breast lymphomasAnne-Thérèse VlastosJean-Bernard DubuissonGeorges VlastosFederica CapannaChristine BouchardyMarie Françoise PelteOlivier JulenIlaria DellacasaThe diagnosis, prognostic factors, and optimal management of primary breast lymphomas (PBL) is difficult. Seven patients recorded at the Geneva Cancer Registry between 1973-1998 were reviewed. Five patient had diffuse large B-cell lymphoma, one a follicular lymphoma and one a MALT-lymphoma. All patients had clinical and radiological findings consistent with breast cancer and underwent mastectomy, which is not indicated in PBL. Diagnosis should be established prior to operative interventions, as fine needle aspiration missed the diagnosis for one patient and intra-operative frozen sections for 3 patients in our study. Five-year and 10-year overall survivals were 57% and 15%, respectively. Of the 3 patients who died from PBL, 2 had tumors that were Bcl-2 positive but Bcl-6 negative. All 3 surviving patients have positive Bcl-2 and Bcl-6 immunostaining, which could be important prognostic factors if confirmed by a larger study.http://www.pagepress.org/journals/index.php/rt/article/view/1015lymphoma, breast, cancer, bcl6, bcl2 |
| spellingShingle | Anne-Thérèse Vlastos Jean-Bernard Dubuisson Georges Vlastos Federica Capanna Christine Bouchardy Marie Françoise Pelte Olivier Julen Ilaria Dellacasa Primary breast lymphomas Rare Tumors lymphoma, breast, cancer, bcl6, bcl2 |
| title | Primary breast lymphomas |
| title_full | Primary breast lymphomas |
| title_fullStr | Primary breast lymphomas |
| title_full_unstemmed | Primary breast lymphomas |
| title_short | Primary breast lymphomas |
| title_sort | primary breast lymphomas |
| topic | lymphoma, breast, cancer, bcl6, bcl2 |
| url | http://www.pagepress.org/journals/index.php/rt/article/view/1015 |
| work_keys_str_mv | AT annetheresevlastos primarybreastlymphomas AT jeanbernarddubuisson primarybreastlymphomas AT georgesvlastos primarybreastlymphomas AT federicacapanna primarybreastlymphomas AT christinebouchardy primarybreastlymphomas AT mariefrancoisepelte primarybreastlymphomas AT olivierjulen primarybreastlymphomas AT ilariadellacasa primarybreastlymphomas |