Correlation of Protumor Effects of Leucine-Rich Repeat Kinase 2 with Interleukin-10 Expression in Lung Squamous Cell Carcinoma
Leucine-rich repeat kinase 2 (LRRK2) is known to play a crucial role in the pathophysiology of neurodegenerative disorders such as Parkinson’s disease. LRRK2 is predominantly expressed in the lung as well as the brain. However, it is unclear whether LRRK2 expression correlates with the pathogenesis...
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| Format: | Article |
| Language: | English |
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The Korean Society for Clinical Laboratory Science
2023-06-01
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| Series: | Korean Journal of Clinical Laboratory Science |
| Subjects: | |
| Online Access: | http://www.kjcls.org/journal/view.html?doi=10.15324/kjcls.2023.55.2.105 |
| _version_ | 1797787196188524544 |
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| author | Sung Won LEE Sangwook PARK |
| author_facet | Sung Won LEE Sangwook PARK |
| author_sort | Sung Won LEE |
| collection | DOAJ |
| description | Leucine-rich repeat kinase 2 (LRRK2) is known to play a crucial role in the pathophysiology of neurodegenerative disorders such as Parkinson’s disease. LRRK2 is predominantly expressed in the lung as well as the brain. However, it is unclear whether LRRK2 expression correlates with the pathogenesis of lung squamous cell carcinoma (LUSC). This study analyzes the prognostic significance of LRRK2 in LUSC using the Kaplan-Meier plotter tool. High expression of LRRK2 is known to be associated with a bad prognosis in patients with LUSC. Patients with high LRRK2 expression, tumor mutational burden, high neoantigen load, and even gender correlation reportedly have the worse survival rates. In the gene expression profiling interactive analysis (GEPIA) database, the severity of pathogenesis in LUSC with high LRRK2 expression positively corresponds to a high expression of anti-inflammatory cytokines but not inflammatory cytokines. Similarly, the increased expression of interleukin (IL)10-related genes was shown to be significantly linked in LRRK2-high LUSC patients having a poor prognosis. Moreover, the tumor immune estimation resource (TIMER) database suggests that macrophages are one of the cellular sources of IL10 in LRRK2-high LUSC patients. Collectively, our results demonstrate that the postulated LRRK2-IL10 axis is a potential therapeutic target and prognostic biomarker for LUSC. |
| first_indexed | 2024-03-13T01:19:31Z |
| format | Article |
| id | doaj.art-75d3b3140ad7490cbef188234e9f5930 |
| institution | Directory Open Access Journal |
| issn | 1738-3544 |
| language | English |
| last_indexed | 2024-03-13T01:19:31Z |
| publishDate | 2023-06-01 |
| publisher | The Korean Society for Clinical Laboratory Science |
| record_format | Article |
| series | Korean Journal of Clinical Laboratory Science |
| spelling | doaj.art-75d3b3140ad7490cbef188234e9f59302023-07-05T05:27:51ZengThe Korean Society for Clinical Laboratory ScienceKorean Journal of Clinical Laboratory Science1738-35442023-06-0155210511210.15324/kjcls.2023.55.2.105kjcls.2023.55.2.105Correlation of Protumor Effects of Leucine-Rich Repeat Kinase 2 with Interleukin-10 Expression in Lung Squamous Cell CarcinomaSung Won LEE0Sangwook PARK1Department of Biomedical Laboratory Science, College of Health and Biomedical Services, Sangji University, Wonju, KoreaDepartment of Biomedical Laboratory Science, College of Health and Biomedical Services, Sangji University, Wonju, KoreaLeucine-rich repeat kinase 2 (LRRK2) is known to play a crucial role in the pathophysiology of neurodegenerative disorders such as Parkinson’s disease. LRRK2 is predominantly expressed in the lung as well as the brain. However, it is unclear whether LRRK2 expression correlates with the pathogenesis of lung squamous cell carcinoma (LUSC). This study analyzes the prognostic significance of LRRK2 in LUSC using the Kaplan-Meier plotter tool. High expression of LRRK2 is known to be associated with a bad prognosis in patients with LUSC. Patients with high LRRK2 expression, tumor mutational burden, high neoantigen load, and even gender correlation reportedly have the worse survival rates. In the gene expression profiling interactive analysis (GEPIA) database, the severity of pathogenesis in LUSC with high LRRK2 expression positively corresponds to a high expression of anti-inflammatory cytokines but not inflammatory cytokines. Similarly, the increased expression of interleukin (IL)10-related genes was shown to be significantly linked in LRRK2-high LUSC patients having a poor prognosis. Moreover, the tumor immune estimation resource (TIMER) database suggests that macrophages are one of the cellular sources of IL10 in LRRK2-high LUSC patients. Collectively, our results demonstrate that the postulated LRRK2-IL10 axis is a potential therapeutic target and prognostic biomarker for LUSC.http://www.kjcls.org/journal/view.html?doi=10.15324/kjcls.2023.55.2.105anti-inflammatory cytokinesgene expression profiling interactive analysiskaplan-meierleucine-rich repeat kinase 2lung squamous cell carcinoma |
| spellingShingle | Sung Won LEE Sangwook PARK Correlation of Protumor Effects of Leucine-Rich Repeat Kinase 2 with Interleukin-10 Expression in Lung Squamous Cell Carcinoma Korean Journal of Clinical Laboratory Science anti-inflammatory cytokines gene expression profiling interactive analysis kaplan-meier leucine-rich repeat kinase 2 lung squamous cell carcinoma |
| title | Correlation of Protumor Effects of Leucine-Rich Repeat Kinase 2 with Interleukin-10 Expression in Lung Squamous Cell Carcinoma |
| title_full | Correlation of Protumor Effects of Leucine-Rich Repeat Kinase 2 with Interleukin-10 Expression in Lung Squamous Cell Carcinoma |
| title_fullStr | Correlation of Protumor Effects of Leucine-Rich Repeat Kinase 2 with Interleukin-10 Expression in Lung Squamous Cell Carcinoma |
| title_full_unstemmed | Correlation of Protumor Effects of Leucine-Rich Repeat Kinase 2 with Interleukin-10 Expression in Lung Squamous Cell Carcinoma |
| title_short | Correlation of Protumor Effects of Leucine-Rich Repeat Kinase 2 with Interleukin-10 Expression in Lung Squamous Cell Carcinoma |
| title_sort | correlation of protumor effects of leucine rich repeat kinase 2 with interleukin 10 expression in lung squamous cell carcinoma |
| topic | anti-inflammatory cytokines gene expression profiling interactive analysis kaplan-meier leucine-rich repeat kinase 2 lung squamous cell carcinoma |
| url | http://www.kjcls.org/journal/view.html?doi=10.15324/kjcls.2023.55.2.105 |
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