A network model of glymphatic flow under different experimentally-motivated parametric scenarios

Summary: Flow of cerebrospinal fluid (CSF) through perivascular spaces (PVSs) in the brain delivers nutrients, clears metabolic waste, and causes edema formation. Brain-wide imaging cannot resolve PVSs, and high-resolution methods cannot access deep tissue. However, theoretical models provide valuab...

Full description

Bibliographic Details
Main Authors: Jeffrey Tithof, Kimberly A.S. Boster, Peter A.R. Bork, Maiken Nedergaard, John H. Thomas, Douglas H. Kelley
Format: Article
Language:English
Published: Elsevier 2022-05-01
Series:iScience
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004222005284