Moderate Intensity of Physical Exercise increased Β (Beta) Cell and Size of Langerhans Islets in Streptozotocin Induced Diabetes Mellitus Rats
Background: The death of β cells Langerhans islets in Diabetes Mellitus (DM) can cause loss of Langerhans islet function and worsen the progression of DM. Physical exercise plays a major part in DM treatment. Aim: to observe the effect of moderate intensity exercise to β (beta) cell numbers and...
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| Format: | Article |
| Language: | English |
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Universitas Airlangga
2019-02-01
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| Series: | Surabaya Physical Medicine and Rehabilitation Journal |
| Subjects: | |
| Online Access: | https://e-journal.unair.ac.id/SPMRJ/article/view/16176/8691 |
| _version_ | 1797787820269502464 |
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| author | Sarah M Nurdin Sri Mardjiati Mei Wulan Nuniek Nugraheni |
| author_facet | Sarah M Nurdin Sri Mardjiati Mei Wulan Nuniek Nugraheni |
| author_sort | Sarah M Nurdin |
| collection | DOAJ |
| description | Background: The death of β cells Langerhans islets in Diabetes Mellitus (DM) can cause loss of Langerhans islet function and worsen the progression of DM. Physical exercise plays a major part in DM treatment.
Aim: to observe the effect of moderate intensity exercise to β (beta) cell numbers and Langerhans islets area size in Streptozotocin (STZ) induced diabetes in rats.
Methods: Thirty adult male Wistar rats (Rattusnorvegicus) divided into 3, Group 1 as the control, Group 2 received 35 mg/kg streptozotocin induction treatment, Group 3 received 35 mg/kg streptozotocin induction and physical exercise, swimming, with moderate intensity 70% from the swimming maximal ability, 9% of body weight load, 4 times a week for 4 weeks. Datas collected were in the form of histopathology slide of pancreatic tissue after receiving treatment for 28 days.
Results: There are significant differences of β-cell pancreas number between group K1 and K2 (p<0,001), group K2 and to K3 (p<0,001). No significant difference between group K1 and K3 (p=0,102). The Langerhans islets area sizes of pancreas tissue between group K1, K2, and K3 are significantly different (p<0,001).
Conclusion: This study shows moderate-intensity physical exercise can increase the number of β cell and average area size of Langerhans islets. The effect of physical exercise depends on the intensity of exercise and the capacity of pancreatic function left of the diabetic. |
| first_indexed | 2024-03-13T01:27:11Z |
| format | Article |
| id | doaj.art-75d5e9a1fbd84f0b9b2c702e6664f550 |
| institution | Directory Open Access Journal |
| issn | 2656-0895 |
| language | English |
| last_indexed | 2024-03-13T01:27:11Z |
| publishDate | 2019-02-01 |
| publisher | Universitas Airlangga |
| record_format | Article |
| series | Surabaya Physical Medicine and Rehabilitation Journal |
| spelling | doaj.art-75d5e9a1fbd84f0b9b2c702e6664f5502023-07-04T12:40:12ZengUniversitas AirlanggaSurabaya Physical Medicine and Rehabilitation Journal2656-08952019-02-01125258Moderate Intensity of Physical Exercise increased Β (Beta) Cell and Size of Langerhans Islets in Streptozotocin Induced Diabetes Mellitus RatsSarah M Nurdin0Sri Mardjiati Mei Wulan1https://orcid.org/0000-0001-8193-1584Nuniek Nugraheni2https://orcid.org/0000-0002-5629-3047Physical Medicine and Rehabilitation Department, Airlangga University, Surabaya, IndonesiaPhysical Medicine and Rehabilitation Department, Airlangga University, Surabaya, IndonesiaPhysical Medicine and Rehabilitation Department, Airlangga University, Surabaya, IndonesiaBackground: The death of β cells Langerhans islets in Diabetes Mellitus (DM) can cause loss of Langerhans islet function and worsen the progression of DM. Physical exercise plays a major part in DM treatment. Aim: to observe the effect of moderate intensity exercise to β (beta) cell numbers and Langerhans islets area size in Streptozotocin (STZ) induced diabetes in rats. Methods: Thirty adult male Wistar rats (Rattusnorvegicus) divided into 3, Group 1 as the control, Group 2 received 35 mg/kg streptozotocin induction treatment, Group 3 received 35 mg/kg streptozotocin induction and physical exercise, swimming, with moderate intensity 70% from the swimming maximal ability, 9% of body weight load, 4 times a week for 4 weeks. Datas collected were in the form of histopathology slide of pancreatic tissue after receiving treatment for 28 days. Results: There are significant differences of β-cell pancreas number between group K1 and K2 (p<0,001), group K2 and to K3 (p<0,001). No significant difference between group K1 and K3 (p=0,102). The Langerhans islets area sizes of pancreas tissue between group K1, K2, and K3 are significantly different (p<0,001). Conclusion: This study shows moderate-intensity physical exercise can increase the number of β cell and average area size of Langerhans islets. The effect of physical exercise depends on the intensity of exercise and the capacity of pancreatic function left of the diabetic.https://e-journal.unair.ac.id/SPMRJ/article/view/16176/8691diabetes mellitusphysical exerciseβ-cellpancreaslangerhans islet morphology |
| spellingShingle | Sarah M Nurdin Sri Mardjiati Mei Wulan Nuniek Nugraheni Moderate Intensity of Physical Exercise increased Β (Beta) Cell and Size of Langerhans Islets in Streptozotocin Induced Diabetes Mellitus Rats Surabaya Physical Medicine and Rehabilitation Journal diabetes mellitus physical exercise β-cellpancreas langerhans islet morphology |
| title | Moderate Intensity of Physical Exercise increased Β (Beta) Cell and Size of Langerhans Islets in Streptozotocin Induced Diabetes Mellitus Rats |
| title_full | Moderate Intensity of Physical Exercise increased Β (Beta) Cell and Size of Langerhans Islets in Streptozotocin Induced Diabetes Mellitus Rats |
| title_fullStr | Moderate Intensity of Physical Exercise increased Β (Beta) Cell and Size of Langerhans Islets in Streptozotocin Induced Diabetes Mellitus Rats |
| title_full_unstemmed | Moderate Intensity of Physical Exercise increased Β (Beta) Cell and Size of Langerhans Islets in Streptozotocin Induced Diabetes Mellitus Rats |
| title_short | Moderate Intensity of Physical Exercise increased Β (Beta) Cell and Size of Langerhans Islets in Streptozotocin Induced Diabetes Mellitus Rats |
| title_sort | moderate intensity of physical exercise increased β beta cell and size of langerhans islets in streptozotocin induced diabetes mellitus rats |
| topic | diabetes mellitus physical exercise β-cellpancreas langerhans islet morphology |
| url | https://e-journal.unair.ac.id/SPMRJ/article/view/16176/8691 |
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