Nanogels as novel drug nanocarriers for CNS drug delivery
Nanogels are highly recognized as adaptable drug delivery systems that significantly contribute to improving various therapies and diagnostic examinations for different human diseases. These three-dimensional, hydrophilic cross-linked polymers have the ability to absorb large amounts of water or bio...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-08-01
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| Series: | Frontiers in Molecular Biosciences |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmolb.2023.1232109/full |
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| author | V. Manimaran R. P. Nivetha T. Tamilanban J. Narayanan Subramaniyan Vetriselvan Subramaniyan Vetriselvan Neeraj Kumar Fuloria Suresh V. Chinni Suresh V. Chinni Mahendran Sekar Shivkanya Fuloria Ling Shing Wong Anupam Biswas Gobinath Ramachawolran Siddharthan Selvaraj |
| author_facet | V. Manimaran R. P. Nivetha T. Tamilanban J. Narayanan Subramaniyan Vetriselvan Subramaniyan Vetriselvan Neeraj Kumar Fuloria Suresh V. Chinni Suresh V. Chinni Mahendran Sekar Shivkanya Fuloria Ling Shing Wong Anupam Biswas Gobinath Ramachawolran Siddharthan Selvaraj |
| author_sort | V. Manimaran |
| collection | DOAJ |
| description | Nanogels are highly recognized as adaptable drug delivery systems that significantly contribute to improving various therapies and diagnostic examinations for different human diseases. These three-dimensional, hydrophilic cross-linked polymers have the ability to absorb large amounts of water or biological fluids. Due to the growing demand for enhancing current therapies, nanogels have emerged as the next-generation drug delivery system. They effectively address the limitations of conventional drug therapy, such as poor stability, large particle size, and low drug loading efficiency. Nanogels find extensive use in the controlled delivery of therapeutic agents, reducing adverse drug effects and enabling lower therapeutic doses while maintaining enhanced efficacy and patient compliance. They are considered an innovative drug delivery system that highlights the shortcomings of traditional methods. This article covers several topics, including the involvement of nanogels in the nanomedicine sector, their advantages and limitations, ideal properties like biocompatibility, biodegradability, drug loading capacity, particle size, permeability, non-immunological response, and colloidal stability. Additionally, it provides information on nanogel classification, synthesis, drug release mechanisms, and various biological applications. The article also discusses barriers associated with brain targeting and the progress of nanogels as nanocarriers for delivering therapeutic agents to the central nervous system. |
| first_indexed | 2024-03-12T15:33:26Z |
| format | Article |
| id | doaj.art-75d5f9203c8e40819b9ca8f122a27862 |
| institution | Directory Open Access Journal |
| issn | 2296-889X |
| language | English |
| last_indexed | 2024-03-12T15:33:26Z |
| publishDate | 2023-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Biosciences |
| spelling | doaj.art-75d5f9203c8e40819b9ca8f122a278622023-08-09T16:58:37ZengFrontiers Media S.A.Frontiers in Molecular Biosciences2296-889X2023-08-011010.3389/fmolb.2023.12321091232109Nanogels as novel drug nanocarriers for CNS drug deliveryV. Manimaran0R. P. Nivetha1T. Tamilanban2J. Narayanan3Subramaniyan Vetriselvan4Subramaniyan Vetriselvan5Neeraj Kumar Fuloria6Suresh V. Chinni7Suresh V. Chinni8Mahendran Sekar9Shivkanya Fuloria10Ling Shing Wong11Anupam Biswas12Gobinath Ramachawolran13Siddharthan Selvaraj14Department of Pharmaceutics, SRM College of Pharmacy, Faculty of Medicine and Health Sciences, SRM Institute of Science and Technology, Kattankulathur, Tamilnadu, IndiaDepartment of Pharmaceutics, SRM College of Pharmacy, Faculty of Medicine and Health Sciences, SRM Institute of Science and Technology, Kattankulathur, Tamilnadu, IndiaDepartment of Pharmaceutics, SRM College of Pharmacy, Faculty of Medicine and Health Sciences, SRM Institute of Science and Technology, Kattankulathur, Tamilnadu, IndiaDepartment of Pharmaceutics, SRM College of Pharmacy, Faculty of Medicine and Health Sciences, SRM Institute of Science and Technology, Kattankulathur, Tamilnadu, IndiaJeffrey Cheah School of Medicine and Health Sciences, Monash University, Bandar Sunway, Selangor Darul Ehsan, MalaysiaCenter for Transdisciplinary Research, Department of Pharmacology, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, IndiaFaculty of Pharmacy, AIMST University, Bedong, Kedah, MalaysiaDepartment of Biochemistry, Faculty of Medicine, Bioscience and Nursing, MAHSA University, Selangor, MalaysiaDepartment of Periodontics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, IndiaSchool of Pharmacy, Monash University Malaysia, Bandar Sunway, Selangor Darul Ehsan, MalaysiaFaculty of Pharmacy, AIMST University, Bedong, Kedah, MalaysiaFaculty of Health and Life Sciences, INTI International University, Nilai, Negeri Sembilan, MalaysiaFaculty of Medicine, AIMST University, Kedah, Malaysia0Department of Foundation, RCSI & UCD Malaysia Campus, Georgetown, Pulau Pinang, Malaysia1Faculty of Dentistry, AIMST University, Kedah, MalaysiaNanogels are highly recognized as adaptable drug delivery systems that significantly contribute to improving various therapies and diagnostic examinations for different human diseases. These three-dimensional, hydrophilic cross-linked polymers have the ability to absorb large amounts of water or biological fluids. Due to the growing demand for enhancing current therapies, nanogels have emerged as the next-generation drug delivery system. They effectively address the limitations of conventional drug therapy, such as poor stability, large particle size, and low drug loading efficiency. Nanogels find extensive use in the controlled delivery of therapeutic agents, reducing adverse drug effects and enabling lower therapeutic doses while maintaining enhanced efficacy and patient compliance. They are considered an innovative drug delivery system that highlights the shortcomings of traditional methods. This article covers several topics, including the involvement of nanogels in the nanomedicine sector, their advantages and limitations, ideal properties like biocompatibility, biodegradability, drug loading capacity, particle size, permeability, non-immunological response, and colloidal stability. Additionally, it provides information on nanogel classification, synthesis, drug release mechanisms, and various biological applications. The article also discusses barriers associated with brain targeting and the progress of nanogels as nanocarriers for delivering therapeutic agents to the central nervous system.https://www.frontiersin.org/articles/10.3389/fmolb.2023.1232109/fullnanogelsblood-brain barrierblood cerebrospinal fluid barrierbrain targetingdrug deliveryCNS |
| spellingShingle | V. Manimaran R. P. Nivetha T. Tamilanban J. Narayanan Subramaniyan Vetriselvan Subramaniyan Vetriselvan Neeraj Kumar Fuloria Suresh V. Chinni Suresh V. Chinni Mahendran Sekar Shivkanya Fuloria Ling Shing Wong Anupam Biswas Gobinath Ramachawolran Siddharthan Selvaraj Nanogels as novel drug nanocarriers for CNS drug delivery Frontiers in Molecular Biosciences nanogels blood-brain barrier blood cerebrospinal fluid barrier brain targeting drug delivery CNS |
| title | Nanogels as novel drug nanocarriers for CNS drug delivery |
| title_full | Nanogels as novel drug nanocarriers for CNS drug delivery |
| title_fullStr | Nanogels as novel drug nanocarriers for CNS drug delivery |
| title_full_unstemmed | Nanogels as novel drug nanocarriers for CNS drug delivery |
| title_short | Nanogels as novel drug nanocarriers for CNS drug delivery |
| title_sort | nanogels as novel drug nanocarriers for cns drug delivery |
| topic | nanogels blood-brain barrier blood cerebrospinal fluid barrier brain targeting drug delivery CNS |
| url | https://www.frontiersin.org/articles/10.3389/fmolb.2023.1232109/full |
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