Characteristics and prognosis of distant metastasis after primary treatment for early‐stage extranodal nasal‐type natural killer/T‐cell lymphoma from the China Lymphoma Collaborative Group database
Abstract This study aimed to investigate the characteristics and prognosis of distant metastasis (DM) after primary treatment for early‐stage extranodal nasal‐type natural killer (NK)/T‐cell lymphoma (ENKTCL). A total of 1619 patients from the China Lymphoma Collaborative Group database were retrosp...
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-02-01
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| Series: | eJHaem |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/jha2.613 |
| _version_ | 1797263264368820224 |
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| author | Xuan Zheng Bao‐Lin Qu Xin Liu Qiu‐Zi Zhong Li‐Ting Qian Yong Yang Xiao‐Rong Hou Xue‐Ying Qiao Hua Wang Yuan Zhu Jian‐Zhong Cao Jun‐Xin Wu Tao Wu Su‐Yu Zhu Mei Shi Hui‐Lai Zhang Xi‐Mei Zhang Hang Su Yu‐Qin Song Jun Zhu Yu‐Jing Zhang Hui‐Qiang Huang Ying Wang Fan Chen Lin Yin Xia He Li‐Ling Zhang Ye‐Xiong Li Shu‐Nan Qi |
| author_facet | Xuan Zheng Bao‐Lin Qu Xin Liu Qiu‐Zi Zhong Li‐Ting Qian Yong Yang Xiao‐Rong Hou Xue‐Ying Qiao Hua Wang Yuan Zhu Jian‐Zhong Cao Jun‐Xin Wu Tao Wu Su‐Yu Zhu Mei Shi Hui‐Lai Zhang Xi‐Mei Zhang Hang Su Yu‐Qin Song Jun Zhu Yu‐Jing Zhang Hui‐Qiang Huang Ying Wang Fan Chen Lin Yin Xia He Li‐Ling Zhang Ye‐Xiong Li Shu‐Nan Qi |
| author_sort | Xuan Zheng |
| collection | DOAJ |
| description | Abstract This study aimed to investigate the characteristics and prognosis of distant metastasis (DM) after primary treatment for early‐stage extranodal nasal‐type natural killer (NK)/T‐cell lymphoma (ENKTCL). A total of 1619 patients from the China Lymphoma Collaborative Group database were retrospectively reviewed. The cumulative incidence of DM was assessed using Fine and Gray's competing risk analysis. The correlation between DM sites was evaluated using phi coefficients, while DM sites were classified using hierarchical clustering. Regression analysis was used to assess the linear correlation between DM‐free survival (DMFS) and overall survival (OS). The 5‐year cumulative DM rate was 26.2%, with the highest annual hazard rate being in the first year (14.9%). The most frequent DM sites were the skin and soft tissues (SSTs, 32.4%) and distant lymph nodes (LNs, 31.3%). DM sites were categorized into four subgroups of distinct prognosis — distant LN, SST, extracutaneous site, and lymphoma‐associated hemophagocytic lymphohistiocytosis. SST or distant LN, solitary metastasis, and late‐onset DM demonstrated a relatively favorable prognosis. Contemporary chemotherapy significantly decreased DM rates and improved DMFS. Decreased DM rates were further associated with increased OS probabilities. Our findings improve the understanding of the variable clinical behaviors of early‐stage ENKTCL based on four distinct DM sites and thus provide guidance for future therapeutic decisions, metastatic surveillance, and translational trial design. |
| first_indexed | 2024-03-12T14:06:43Z |
| format | Article |
| id | doaj.art-75d616809d12419c8c8387747161de72 |
| institution | Directory Open Access Journal |
| issn | 2688-6146 |
| language | English |
| last_indexed | 2024-04-25T00:10:15Z |
| publishDate | 2023-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | eJHaem |
| spelling | doaj.art-75d616809d12419c8c8387747161de722024-03-13T13:30:47ZengWileyeJHaem2688-61462023-02-0141788910.1002/jha2.613Characteristics and prognosis of distant metastasis after primary treatment for early‐stage extranodal nasal‐type natural killer/T‐cell lymphoma from the China Lymphoma Collaborative Group databaseXuan Zheng0Bao‐Lin Qu1Xin Liu2Qiu‐Zi Zhong3Li‐Ting Qian4Yong Yang5Xiao‐Rong Hou6Xue‐Ying Qiao7Hua Wang8Yuan Zhu9Jian‐Zhong Cao10Jun‐Xin Wu11Tao Wu12Su‐Yu Zhu13Mei Shi14Hui‐Lai Zhang15Xi‐Mei Zhang16Hang Su17Yu‐Qin Song18Jun Zhu19Yu‐Jing Zhang20Hui‐Qiang Huang21Ying Wang22Fan Chen23Lin Yin24Xia He25Li‐Ling Zhang26Ye‐Xiong Li27Shu‐Nan Qi28Department of Radiation Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing ChinaDepartment of Radiation Oncology The General Hospital of Chinese People's Liberation Army Beijing ChinaDepartment of Radiation Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing ChinaDepartment of Radiation Oncology Beijing Hospital, National Geriatric Medical Center Beijing ChinaDepartment of Radiation Oncology The Affiliated Provincial Hospital of Anhui Medical University Hefei ChinaDepartment of Radiation Oncology Fujian Medical University Union Hospital Fuzhou ChinaDepartment of Radiation Oncology Peking Union Medical College Hospital Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC) Beijing ChinaDepartment of Radiation Oncology The Fourth Hospital of Hebei Medical University Shijiazhuang ChinaDepartment of Medical Oncology Second Affiliated Hospital of Nanchang University Nanchang ChinaDepartment of Radiation Oncology Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Zhejiang Key Laboratory of Radiation Oncology Zhejiang ChinaDepartment of Radiation Oncology Shanxi Cancer Hospital and the Affiliated Cancer Hospital of Shanxi Medical University Taiyuan ChinaDepartment of Radiation Oncology Fujian Provincial Cancer Hospital Fuzhou ChinaDepartment of Lymphoma Affiliated Hospital of Guizhou Medical University Guizhou Cancer Hospital Guiyang ChinaDepartment of Radiation Oncology Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine Changsha ChinaDepartment of Radiation Oncology Xijing Hospital of Fourth Military Medical University Xi'an ChinaDepartment of Lymphoma Tianjin Medical University Cancer Institute & Hospital, Key Laboratory of Cancer Prevention and Therapy, National Clinical Research Center for Cancer Tianjin ChinaDepartment of Radiation Oncology Tianjin Medical University Cancer Institute & Hospital, Key Laboratory of Cancer Prevention and Therapy, National Clinical Research Center for Cancer Tianjin ChinaDepartment of Lymphoma The Fifth Medical Center of PLA General Hospital Beijing ChinaKey laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of LymphomaPeking University Cancer Hospital & Institute Beijing ChinaKey laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of LymphomaPeking University Cancer Hospital & Institute Beijing ChinaDepartment of Radiation Oncology Sun Yat‐sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine Guangzhou ChinaDepartment of Medical Oncology Sun Yat‐sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine Guangzhou ChinaDepartment of Radiation Oncology Chongqing University Cancer Hospital and Chongqing Cancer Hospital Chongqing ChinaDepartment of Radiation OncologyAffiliated Hospital of Qinghai University Qinghai ChinaDepartment of Radiation OncologyAffiliated Hospital of Qinghai University Qinghai ChinaDepartment of Radiation Oncology Jiangsu Cancer Hospital and Jiangsu Institute of Cancer Research Nanjing ChinaCancer Center Union Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan ChinaDepartment of Radiation Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing ChinaDepartment of Radiation Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing ChinaAbstract This study aimed to investigate the characteristics and prognosis of distant metastasis (DM) after primary treatment for early‐stage extranodal nasal‐type natural killer (NK)/T‐cell lymphoma (ENKTCL). A total of 1619 patients from the China Lymphoma Collaborative Group database were retrospectively reviewed. The cumulative incidence of DM was assessed using Fine and Gray's competing risk analysis. The correlation between DM sites was evaluated using phi coefficients, while DM sites were classified using hierarchical clustering. Regression analysis was used to assess the linear correlation between DM‐free survival (DMFS) and overall survival (OS). The 5‐year cumulative DM rate was 26.2%, with the highest annual hazard rate being in the first year (14.9%). The most frequent DM sites were the skin and soft tissues (SSTs, 32.4%) and distant lymph nodes (LNs, 31.3%). DM sites were categorized into four subgroups of distinct prognosis — distant LN, SST, extracutaneous site, and lymphoma‐associated hemophagocytic lymphohistiocytosis. SST or distant LN, solitary metastasis, and late‐onset DM demonstrated a relatively favorable prognosis. Contemporary chemotherapy significantly decreased DM rates and improved DMFS. Decreased DM rates were further associated with increased OS probabilities. Our findings improve the understanding of the variable clinical behaviors of early‐stage ENKTCL based on four distinct DM sites and thus provide guidance for future therapeutic decisions, metastatic surveillance, and translational trial design.https://doi.org/10.1002/jha2.613distant metastasisNK/T‐cell lymphomapatterns of metastasesprognosis |
| spellingShingle | Xuan Zheng Bao‐Lin Qu Xin Liu Qiu‐Zi Zhong Li‐Ting Qian Yong Yang Xiao‐Rong Hou Xue‐Ying Qiao Hua Wang Yuan Zhu Jian‐Zhong Cao Jun‐Xin Wu Tao Wu Su‐Yu Zhu Mei Shi Hui‐Lai Zhang Xi‐Mei Zhang Hang Su Yu‐Qin Song Jun Zhu Yu‐Jing Zhang Hui‐Qiang Huang Ying Wang Fan Chen Lin Yin Xia He Li‐Ling Zhang Ye‐Xiong Li Shu‐Nan Qi Characteristics and prognosis of distant metastasis after primary treatment for early‐stage extranodal nasal‐type natural killer/T‐cell lymphoma from the China Lymphoma Collaborative Group database eJHaem distant metastasis NK/T‐cell lymphoma patterns of metastases prognosis |
| title | Characteristics and prognosis of distant metastasis after primary treatment for early‐stage extranodal nasal‐type natural killer/T‐cell lymphoma from the China Lymphoma Collaborative Group database |
| title_full | Characteristics and prognosis of distant metastasis after primary treatment for early‐stage extranodal nasal‐type natural killer/T‐cell lymphoma from the China Lymphoma Collaborative Group database |
| title_fullStr | Characteristics and prognosis of distant metastasis after primary treatment for early‐stage extranodal nasal‐type natural killer/T‐cell lymphoma from the China Lymphoma Collaborative Group database |
| title_full_unstemmed | Characteristics and prognosis of distant metastasis after primary treatment for early‐stage extranodal nasal‐type natural killer/T‐cell lymphoma from the China Lymphoma Collaborative Group database |
| title_short | Characteristics and prognosis of distant metastasis after primary treatment for early‐stage extranodal nasal‐type natural killer/T‐cell lymphoma from the China Lymphoma Collaborative Group database |
| title_sort | characteristics and prognosis of distant metastasis after primary treatment for early stage extranodal nasal type natural killer t cell lymphoma from the china lymphoma collaborative group database |
| topic | distant metastasis NK/T‐cell lymphoma patterns of metastases prognosis |
| url | https://doi.org/10.1002/jha2.613 |
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