Formulation of mucoadhesive microspheres of rosiglitazone maleate and its in vitro evaluation using ionotropic gelation technique
Aim: The objective of the present study is to design and evaluate mucoadhesive microspheres for oral controlled release. Materials and Method: Rosiglitazone maleate microspheres with a coat consisting of alginate and a mucoadhesive polymer sodium carboxymethylcellulose, carbopol 934P and hydroxyprop...
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| Format: | Article |
| Language: | English |
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Facultad de Farmacia, Universidad de Granada
2015-01-01
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| Series: | Ars Pharmaceutica |
| Subjects: | |
| Online Access: | http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S2340-98942015000200004&lng=en&tlng=en |
| _version_ | 1818318006128738304 |
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| author | Akanksha Garud Navneet Garud |
| author_facet | Akanksha Garud Navneet Garud |
| author_sort | Akanksha Garud |
| collection | DOAJ |
| description | Aim: The objective of the present study is to design and evaluate mucoadhesive microspheres for oral controlled release. Materials and Method: Rosiglitazone maleate microspheres with a coat consisting of alginate and a mucoadhesive polymer sodium carboxymethylcellulose, carbopol 934P and hydroxypropylmethylcellulose were prepared by an orifice-ionic gelation process. The microspheres were evaluated for FTIR studies, morphology, particle size, micromeritic properties, percentage entrapment efficiency, in-vitro wash-off test and in-vitro release studies. Results: The resulting microspheres were spherical and free flowing. The percent entrapment efficiency was 68.2 to 85.6%. The microspheres exhibited good mucoadhesive property in the in vitro wash-off test. Rosiglitazone release from these mucoadhesive microspheres was slow and extended over 12 h duration of time depending on the composition of coat. Conclusions: The prepared mucoadhesive microspheres are thus suitable for oral controlled release of Rosiglitazone maleate and thereby help in the management of type II diabetes mellitus. |
| first_indexed | 2024-12-13T09:46:21Z |
| format | Article |
| id | doaj.art-75d734db61d64b4e8da8cd3afdeac209 |
| institution | Directory Open Access Journal |
| issn | 2340-9894 |
| language | English |
| last_indexed | 2024-12-13T09:46:21Z |
| publishDate | 2015-01-01 |
| publisher | Facultad de Farmacia, Universidad de Granada |
| record_format | Article |
| series | Ars Pharmaceutica |
| spelling | doaj.art-75d734db61d64b4e8da8cd3afdeac2092022-12-21T23:52:04ZengFacultad de Farmacia, Universidad de GranadaArs Pharmaceutica2340-98942015-01-01562101107S2340-98942015000200004Formulation of mucoadhesive microspheres of rosiglitazone maleate and its in vitro evaluation using ionotropic gelation techniqueAkanksha Garud0Navneet Garud1Jiwaji UniversityJiwaji UniversityAim: The objective of the present study is to design and evaluate mucoadhesive microspheres for oral controlled release. Materials and Method: Rosiglitazone maleate microspheres with a coat consisting of alginate and a mucoadhesive polymer sodium carboxymethylcellulose, carbopol 934P and hydroxypropylmethylcellulose were prepared by an orifice-ionic gelation process. The microspheres were evaluated for FTIR studies, morphology, particle size, micromeritic properties, percentage entrapment efficiency, in-vitro wash-off test and in-vitro release studies. Results: The resulting microspheres were spherical and free flowing. The percent entrapment efficiency was 68.2 to 85.6%. The microspheres exhibited good mucoadhesive property in the in vitro wash-off test. Rosiglitazone release from these mucoadhesive microspheres was slow and extended over 12 h duration of time depending on the composition of coat. Conclusions: The prepared mucoadhesive microspheres are thus suitable for oral controlled release of Rosiglitazone maleate and thereby help in the management of type II diabetes mellitus.http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S2340-98942015000200004&lng=en&tlng=enmicroesferas mucoadherentesrosiglitazona maleatoliberación controlada |
| spellingShingle | Akanksha Garud Navneet Garud Formulation of mucoadhesive microspheres of rosiglitazone maleate and its in vitro evaluation using ionotropic gelation technique Ars Pharmaceutica microesferas mucoadherentes rosiglitazona maleato liberación controlada |
| title | Formulation of mucoadhesive microspheres of rosiglitazone maleate and its in vitro evaluation using ionotropic gelation technique |
| title_full | Formulation of mucoadhesive microspheres of rosiglitazone maleate and its in vitro evaluation using ionotropic gelation technique |
| title_fullStr | Formulation of mucoadhesive microspheres of rosiglitazone maleate and its in vitro evaluation using ionotropic gelation technique |
| title_full_unstemmed | Formulation of mucoadhesive microspheres of rosiglitazone maleate and its in vitro evaluation using ionotropic gelation technique |
| title_short | Formulation of mucoadhesive microspheres of rosiglitazone maleate and its in vitro evaluation using ionotropic gelation technique |
| title_sort | formulation of mucoadhesive microspheres of rosiglitazone maleate and its in vitro evaluation using ionotropic gelation technique |
| topic | microesferas mucoadherentes rosiglitazona maleato liberación controlada |
| url | http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S2340-98942015000200004&lng=en&tlng=en |
| work_keys_str_mv | AT akankshagarud formulationofmucoadhesivemicrospheresofrosiglitazonemaleateanditsinvitroevaluationusingionotropicgelationtechnique AT navneetgarud formulationofmucoadhesivemicrospheresofrosiglitazonemaleateanditsinvitroevaluationusingionotropicgelationtechnique |