<it>In silico </it>analysis highlights the frequency and diversity of type 1 lantibiotic gene clusters in genome sequenced bacteria
<p>Abstract</p> <p>Background</p> <p>Lantibiotics are lanthionine-containing, post-translationally modified antimicrobial peptides. These peptides have significant, but largely untapped, potential as preservatives and chemotherapeutic agents. Type 1 lantibiotics are tho...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2010-11-01
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| Series: | BMC Genomics |
| Online Access: | http://www.biomedcentral.com/1471-2164/11/679 |
| _version_ | 1818640519761231872 |
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| author | Ross R Paul O'Sullivan Orla Marsh Alan J Cotter Paul D Hill Colin |
| author_facet | Ross R Paul O'Sullivan Orla Marsh Alan J Cotter Paul D Hill Colin |
| author_sort | Ross R Paul |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Lantibiotics are lanthionine-containing, post-translationally modified antimicrobial peptides. These peptides have significant, but largely untapped, potential as preservatives and chemotherapeutic agents. Type 1 lantibiotics are those in which lanthionine residues are introduced into the structural peptide (LanA) through the activity of separate lanthionine dehydratase (LanB) and lanthionine synthetase (LanC) enzymes. Here we take advantage of the conserved nature of LanC enzymes to devise an <it>in silico </it>approach to identify potential lantibiotic-encoding gene clusters in genome sequenced bacteria.</p> <p>Results</p> <p>In total 49 novel type 1 lantibiotic clusters were identified which unexpectedly were associated with species, genera and even phyla of bacteria which have not previously been associated with lantibiotic production.</p> <p>Conclusions</p> <p>Multiple type 1 lantibiotic gene clusters were identified at a frequency that suggests that these antimicrobials are much more widespread than previously thought. These clusters represent a rich repository which can yield a large number of valuable novel antimicrobials and biosynthetic enzymes.</p> |
| first_indexed | 2024-12-16T23:12:34Z |
| format | Article |
| id | doaj.art-75d7a83379b8429e8cd34dea4d665d49 |
| institution | Directory Open Access Journal |
| issn | 1471-2164 |
| language | English |
| last_indexed | 2024-12-16T23:12:34Z |
| publishDate | 2010-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Genomics |
| spelling | doaj.art-75d7a83379b8429e8cd34dea4d665d492022-12-21T22:12:24ZengBMCBMC Genomics1471-21642010-11-0111167910.1186/1471-2164-11-679<it>In silico </it>analysis highlights the frequency and diversity of type 1 lantibiotic gene clusters in genome sequenced bacteriaRoss R PaulO'Sullivan OrlaMarsh Alan JCotter Paul DHill Colin<p>Abstract</p> <p>Background</p> <p>Lantibiotics are lanthionine-containing, post-translationally modified antimicrobial peptides. These peptides have significant, but largely untapped, potential as preservatives and chemotherapeutic agents. Type 1 lantibiotics are those in which lanthionine residues are introduced into the structural peptide (LanA) through the activity of separate lanthionine dehydratase (LanB) and lanthionine synthetase (LanC) enzymes. Here we take advantage of the conserved nature of LanC enzymes to devise an <it>in silico </it>approach to identify potential lantibiotic-encoding gene clusters in genome sequenced bacteria.</p> <p>Results</p> <p>In total 49 novel type 1 lantibiotic clusters were identified which unexpectedly were associated with species, genera and even phyla of bacteria which have not previously been associated with lantibiotic production.</p> <p>Conclusions</p> <p>Multiple type 1 lantibiotic gene clusters were identified at a frequency that suggests that these antimicrobials are much more widespread than previously thought. These clusters represent a rich repository which can yield a large number of valuable novel antimicrobials and biosynthetic enzymes.</p>http://www.biomedcentral.com/1471-2164/11/679 |
| spellingShingle | Ross R Paul O'Sullivan Orla Marsh Alan J Cotter Paul D Hill Colin <it>In silico </it>analysis highlights the frequency and diversity of type 1 lantibiotic gene clusters in genome sequenced bacteria BMC Genomics |
| title | <it>In silico </it>analysis highlights the frequency and diversity of type 1 lantibiotic gene clusters in genome sequenced bacteria |
| title_full | <it>In silico </it>analysis highlights the frequency and diversity of type 1 lantibiotic gene clusters in genome sequenced bacteria |
| title_fullStr | <it>In silico </it>analysis highlights the frequency and diversity of type 1 lantibiotic gene clusters in genome sequenced bacteria |
| title_full_unstemmed | <it>In silico </it>analysis highlights the frequency and diversity of type 1 lantibiotic gene clusters in genome sequenced bacteria |
| title_short | <it>In silico </it>analysis highlights the frequency and diversity of type 1 lantibiotic gene clusters in genome sequenced bacteria |
| title_sort | it in silico it analysis highlights the frequency and diversity of type 1 lantibiotic gene clusters in genome sequenced bacteria |
| url | http://www.biomedcentral.com/1471-2164/11/679 |
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