Small extracellular vesicles secreted from senescent cells promote cancer cell proliferation through EphA2
Although senescent cell secretome can promote the growth of surrounding cancer cells, the role of extracellular vesicles in this process has not been well understood. Here the authors show that ROS increase the sorting of EphA2 into extracellular vesicles in senescent cells, which promotes prolifera...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2017-06-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms15728 |
| _version_ | 1818345352499036160 |
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| author | Masaki Takasugi Ryo Okada Akiko Takahashi David Virya Chen Sugiko Watanabe Eiji Hara |
| author_facet | Masaki Takasugi Ryo Okada Akiko Takahashi David Virya Chen Sugiko Watanabe Eiji Hara |
| author_sort | Masaki Takasugi |
| collection | DOAJ |
| description | Although senescent cell secretome can promote the growth of surrounding cancer cells, the role of extracellular vesicles in this process has not been well understood. Here the authors show that ROS increase the sorting of EphA2 into extracellular vesicles in senescent cells, which promotes proliferation of cancer cells. |
| first_indexed | 2024-12-13T17:01:01Z |
| format | Article |
| id | doaj.art-75d7ca7f2bd04c92ac6d5b041481b7ec |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-13T17:01:01Z |
| publishDate | 2017-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-75d7ca7f2bd04c92ac6d5b041481b7ec2022-12-21T23:37:48ZengNature PortfolioNature Communications2041-17232017-06-018111110.1038/ncomms15728Small extracellular vesicles secreted from senescent cells promote cancer cell proliferation through EphA2Masaki Takasugi0Ryo Okada1Akiko Takahashi2David Virya Chen3Sugiko Watanabe4Eiji Hara5Department of Molecular Microbiology, Research Institute for Microbial Diseases, Osaka UniversityDivision of Cancer Biology, Cancer Institute, Japanese Foundation for Cancer ResearchDivision of Cancer Biology, Cancer Institute, Japanese Foundation for Cancer ResearchDepartment of Molecular Microbiology, Research Institute for Microbial Diseases, Osaka UniversityDepartment of Molecular Microbiology, Research Institute for Microbial Diseases, Osaka UniversityDepartment of Molecular Microbiology, Research Institute for Microbial Diseases, Osaka UniversityAlthough senescent cell secretome can promote the growth of surrounding cancer cells, the role of extracellular vesicles in this process has not been well understood. Here the authors show that ROS increase the sorting of EphA2 into extracellular vesicles in senescent cells, which promotes proliferation of cancer cells.https://doi.org/10.1038/ncomms15728 |
| spellingShingle | Masaki Takasugi Ryo Okada Akiko Takahashi David Virya Chen Sugiko Watanabe Eiji Hara Small extracellular vesicles secreted from senescent cells promote cancer cell proliferation through EphA2 Nature Communications |
| title | Small extracellular vesicles secreted from senescent cells promote cancer cell proliferation through EphA2 |
| title_full | Small extracellular vesicles secreted from senescent cells promote cancer cell proliferation through EphA2 |
| title_fullStr | Small extracellular vesicles secreted from senescent cells promote cancer cell proliferation through EphA2 |
| title_full_unstemmed | Small extracellular vesicles secreted from senescent cells promote cancer cell proliferation through EphA2 |
| title_short | Small extracellular vesicles secreted from senescent cells promote cancer cell proliferation through EphA2 |
| title_sort | small extracellular vesicles secreted from senescent cells promote cancer cell proliferation through epha2 |
| url | https://doi.org/10.1038/ncomms15728 |
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