Tumor Infiltrating Lymphocytes in Different Stages of Malignant Melanoma and Correlation with Tumor Stage and Other Prognostic Factors: A Retrospective Multicenter Study
Background: Melanoma is one of the most immunogenic tumors that causes a significant immune response. Tumor infiltrating lymphocytes are an important part of this response. Tumor infiltrating lymphocytes are lymphocytes in close association with tumor cells that have infiltrated tumor nests. In t...
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| Format: | Article |
| Language: | English |
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Shiraz University of Medical Sciences
2017-09-01
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| Series: | Middle East Journal of Cancer |
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| Online Access: | http://mejc.sums.ac.ir/index.php/mejc/article/view/551/325 |
| _version_ | 1818677228454543360 |
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| author | Alireza Ghanadan Amir-Hoshang Ehsani Ali-Mohammad Farahmand Mojtaba Mirzaei |
| author_facet | Alireza Ghanadan Amir-Hoshang Ehsani Ali-Mohammad Farahmand Mojtaba Mirzaei |
| author_sort | Alireza Ghanadan |
| collection | DOAJ |
| description | Background: Melanoma is one of the most immunogenic tumors that causes a
significant immune response. Tumor infiltrating lymphocytes are an important part of
this response. Tumor infiltrating lymphocytes are lymphocytes in close association with
tumor cells that have infiltrated tumor nests. In this study, we attempt to evaluate the
relationship of tumor infiltrating lymphocytes in malignant melanoma with histopathologic
findings, tumor stage, and other prognostic factors.
Methods: This was a retrospective cross-sectional study. We re-evaluated patients’
specimens and categorized the tumor infiltrating lymphocytes as grades 0, 1, 2, or 3
based on density and distribution of the infiltrating lymphocytes.
Results:We enrolled 111 patients with a mean age of 59.33±14.68 years, and a male
to female ratio of 1.09. There was no evidence of tumor infiltrating lymphocytes in 17.1%
of patients. The melanoma subtypes had the following tumor infiltrating lymphocyte
grades: 1 (47.7%), 2 (28.8%), and 3 (6.3%). Cancer stage significantly decreased with
increasing grade of tumor infiltrating lymphocyte (P<0.001). Although numerous
histopathologic findings had a relationship with tumor infiltrating lymphocytes, only
microsatellitosis had a significant relation after adjustments for melanoma stage (P<
0.001).
Conclusion: Increased density of tumor infiltrating lymphocytes can show a more
effective immune response against melanoma. This response can limit cancer progression
and result in tumor diagnosis at lower stages of the disease. |
| first_indexed | 2024-12-17T08:56:02Z |
| format | Article |
| id | doaj.art-75d80026fed74e0799b0bf81b6e3b098 |
| institution | Directory Open Access Journal |
| issn | 2008-6709 2008-6687 |
| language | English |
| last_indexed | 2024-12-17T08:56:02Z |
| publishDate | 2017-09-01 |
| publisher | Shiraz University of Medical Sciences |
| record_format | Article |
| series | Middle East Journal of Cancer |
| spelling | doaj.art-75d80026fed74e0799b0bf81b6e3b0982022-12-21T21:55:58ZengShiraz University of Medical SciencesMiddle East Journal of Cancer2008-67092008-66872017-09-0184207212Tumor Infiltrating Lymphocytes in Different Stages of Malignant Melanoma and Correlation with Tumor Stage and Other Prognostic Factors: A Retrospective Multicenter StudyAlireza Ghanadan0Amir-Hoshang Ehsani1Ali-Mohammad Farahmand2Mojtaba Mirzaei3Department of Dermatopathology, Razi Dermatology Hospital, Tehran University of Medical Sciences, Tehran, IranAutoimmune Bullous Diseases Research Center, Department of Dermatology, Razi Dermatology Hospital, Tehran University of Medical Sciences, Tehran, IranDepartment of Dermatopathology, Razi Dermatology Hospital, Tehran University of Medical Sciences, Tehran, IranDepartment of Dermatopathology, Razi Dermatology Hospital, Tehran University of Medical Sciences, Tehran, IranBackground: Melanoma is one of the most immunogenic tumors that causes a significant immune response. Tumor infiltrating lymphocytes are an important part of this response. Tumor infiltrating lymphocytes are lymphocytes in close association with tumor cells that have infiltrated tumor nests. In this study, we attempt to evaluate the relationship of tumor infiltrating lymphocytes in malignant melanoma with histopathologic findings, tumor stage, and other prognostic factors. Methods: This was a retrospective cross-sectional study. We re-evaluated patients’ specimens and categorized the tumor infiltrating lymphocytes as grades 0, 1, 2, or 3 based on density and distribution of the infiltrating lymphocytes. Results:We enrolled 111 patients with a mean age of 59.33±14.68 years, and a male to female ratio of 1.09. There was no evidence of tumor infiltrating lymphocytes in 17.1% of patients. The melanoma subtypes had the following tumor infiltrating lymphocyte grades: 1 (47.7%), 2 (28.8%), and 3 (6.3%). Cancer stage significantly decreased with increasing grade of tumor infiltrating lymphocyte (P<0.001). Although numerous histopathologic findings had a relationship with tumor infiltrating lymphocytes, only microsatellitosis had a significant relation after adjustments for melanoma stage (P< 0.001). Conclusion: Increased density of tumor infiltrating lymphocytes can show a more effective immune response against melanoma. This response can limit cancer progression and result in tumor diagnosis at lower stages of the disease.http://mejc.sums.ac.ir/index.php/mejc/article/view/551/325MelanomaTumor infiltrating lymphocytesTumor stageImmune responsePrognostic factor |
| spellingShingle | Alireza Ghanadan Amir-Hoshang Ehsani Ali-Mohammad Farahmand Mojtaba Mirzaei Tumor Infiltrating Lymphocytes in Different Stages of Malignant Melanoma and Correlation with Tumor Stage and Other Prognostic Factors: A Retrospective Multicenter Study Middle East Journal of Cancer Melanoma Tumor infiltrating lymphocytes Tumor stage Immune response Prognostic factor |
| title | Tumor Infiltrating Lymphocytes in Different Stages of Malignant Melanoma and Correlation with Tumor Stage and Other Prognostic Factors: A Retrospective Multicenter Study |
| title_full | Tumor Infiltrating Lymphocytes in Different Stages of Malignant Melanoma and Correlation with Tumor Stage and Other Prognostic Factors: A Retrospective Multicenter Study |
| title_fullStr | Tumor Infiltrating Lymphocytes in Different Stages of Malignant Melanoma and Correlation with Tumor Stage and Other Prognostic Factors: A Retrospective Multicenter Study |
| title_full_unstemmed | Tumor Infiltrating Lymphocytes in Different Stages of Malignant Melanoma and Correlation with Tumor Stage and Other Prognostic Factors: A Retrospective Multicenter Study |
| title_short | Tumor Infiltrating Lymphocytes in Different Stages of Malignant Melanoma and Correlation with Tumor Stage and Other Prognostic Factors: A Retrospective Multicenter Study |
| title_sort | tumor infiltrating lymphocytes in different stages of malignant melanoma and correlation with tumor stage and other prognostic factors a retrospective multicenter study |
| topic | Melanoma Tumor infiltrating lymphocytes Tumor stage Immune response Prognostic factor |
| url | http://mejc.sums.ac.ir/index.php/mejc/article/view/551/325 |
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