Synergistic Effect of Acetazolamide-(2-hydroxy)propyl β-Cyclodextrin in Timolol Liposomes for Decreasing and Prolonging Intraocular Pressure Levels

Synergistic Effect of Acetazolamide-(2-hydroxy)propyl β-Cyclodextrin in Timolol Liposomes for Decreasing and Prolonging Intraocular Pressure Levels

The purpose of this study was to design, for the first time, a co-loaded liposomal formulation (CLL) for treatment of glaucoma including timolol maleate (TM) in the lipid bilayer and acetazolamide (Acz)-(2-hydroxy)propyl β-cyclodextrin (HPβCD) complexes (AczHP) solubilized in the aqueous core of lip...

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Bibliographic Details
Main Authors: Carmen M. Arroyo-García, Daniela Quinteros, Santiago D. Palma, Cesáreo J. Jiménez de los Santos, José R. Moyano, Antonio M. Rabasco, María Luisa González-Rodríguez
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Pharmaceutics
Subjects:
liposome
glaucoma
co-loading
timolol
acetazolamide
design of experiments
Online Access:https://www.mdpi.com/1999-4923/13/12/2010

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