Constituents of Psoralea corylifolia Fruits and Their Effects on Methicillin-Resistant Staphylococcus aureus
Two new flavonoids, bakuisoflavone (1) and bakuflavanone (2), together with 15 known compounds, were isolated from the fruits of Psoralea corylifolia, and their structures were characterized by spectroscopic data. The effects of the isolated compounds on methicillin-resistant Staphylococcus aureus w...
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| Format: | Article |
| Language: | English |
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MDPI AG
2015-07-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/20/7/12500 |
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| author | Yanmei Cui Shoko Taniguchi Teruo Kuroda Tsutomu Hatano |
| author_facet | Yanmei Cui Shoko Taniguchi Teruo Kuroda Tsutomu Hatano |
| author_sort | Yanmei Cui |
| collection | DOAJ |
| description | Two new flavonoids, bakuisoflavone (1) and bakuflavanone (2), together with 15 known compounds, were isolated from the fruits of Psoralea corylifolia, and their structures were characterized by spectroscopic data. The effects of the isolated compounds on methicillin-resistant Staphylococcus aureus were also examined. We found that two compounds, isobavachalcone (10) and bakuchiol (12), showed noticeable antibacterial effects on the MRSA strains examined. Quantitation of the major constituents, including anti-MRSA constituents, was then performed. The results showed individual contents of 1.26%–16.49% (w/w) among the examined compounds in the ethyl acetate extract from P. corylifolia fruits. |
| first_indexed | 2024-12-19T10:02:17Z |
| format | Article |
| id | doaj.art-75dad50edb2146249d6f114e15a7f888 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-19T10:02:17Z |
| publishDate | 2015-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-75dad50edb2146249d6f114e15a7f8882022-12-21T20:26:37ZengMDPI AGMolecules1420-30492015-07-01207125001251110.3390/molecules200712500molecules200712500Constituents of Psoralea corylifolia Fruits and Their Effects on Methicillin-Resistant Staphylococcus aureusYanmei Cui0Shoko Taniguchi1Teruo Kuroda2Tsutomu Hatano3Department of Natural Product Chemistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Tsushima-naka, Kita-ku, Okayama 700-8530, JapanDepartment of Natural Product Chemistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Tsushima-naka, Kita-ku, Okayama 700-8530, JapanDrug Discovery Technology Center, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Tsushima-naka, Kita-ku, Okayama 700-8530, JapanDepartment of Natural Product Chemistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Tsushima-naka, Kita-ku, Okayama 700-8530, JapanTwo new flavonoids, bakuisoflavone (1) and bakuflavanone (2), together with 15 known compounds, were isolated from the fruits of Psoralea corylifolia, and their structures were characterized by spectroscopic data. The effects of the isolated compounds on methicillin-resistant Staphylococcus aureus were also examined. We found that two compounds, isobavachalcone (10) and bakuchiol (12), showed noticeable antibacterial effects on the MRSA strains examined. Quantitation of the major constituents, including anti-MRSA constituents, was then performed. The results showed individual contents of 1.26%–16.49% (w/w) among the examined compounds in the ethyl acetate extract from P. corylifolia fruits.http://www.mdpi.com/1420-3049/20/7/12500Psoralea corylifoliabakuisoflavonebakuflavanonemethicillin-resistant Staphylococcus aureus |
| spellingShingle | Yanmei Cui Shoko Taniguchi Teruo Kuroda Tsutomu Hatano Constituents of Psoralea corylifolia Fruits and Their Effects on Methicillin-Resistant Staphylococcus aureus Molecules Psoralea corylifolia bakuisoflavone bakuflavanone methicillin-resistant Staphylococcus aureus |
| title | Constituents of Psoralea corylifolia Fruits and Their Effects on Methicillin-Resistant Staphylococcus aureus |
| title_full | Constituents of Psoralea corylifolia Fruits and Their Effects on Methicillin-Resistant Staphylococcus aureus |
| title_fullStr | Constituents of Psoralea corylifolia Fruits and Their Effects on Methicillin-Resistant Staphylococcus aureus |
| title_full_unstemmed | Constituents of Psoralea corylifolia Fruits and Their Effects on Methicillin-Resistant Staphylococcus aureus |
| title_short | Constituents of Psoralea corylifolia Fruits and Their Effects on Methicillin-Resistant Staphylococcus aureus |
| title_sort | constituents of psoralea corylifolia fruits and their effects on methicillin resistant staphylococcus aureus |
| topic | Psoralea corylifolia bakuisoflavone bakuflavanone methicillin-resistant Staphylococcus aureus |
| url | http://www.mdpi.com/1420-3049/20/7/12500 |
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