Associations between food groups and liver cancer: a systematic review and meta-analysis of observational studies
Abstract Context Diet is emerging as a modifiable component of lifestyle for influencing the incidence of liver cancer. Objective To investigate and quantify the potential relationship between food groups and liver cancer. Data sources PubMed and Web of Science were searched for eligible observation...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-06-01
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| Series: | Nutrition Journal |
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| Online Access: | https://doi.org/10.1186/s12937-023-00858-5 |
| _version_ | 1797795851455692800 |
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| author | Ke Liu Weiwei Chen Yi Zhou Liuhong Xu Xiaohui Sun Yingying Mao Ding Ye |
| author_facet | Ke Liu Weiwei Chen Yi Zhou Liuhong Xu Xiaohui Sun Yingying Mao Ding Ye |
| author_sort | Ke Liu |
| collection | DOAJ |
| description | Abstract Context Diet is emerging as a modifiable component of lifestyle for influencing the incidence of liver cancer. Objective To investigate and quantify the potential relationship between food groups and liver cancer. Data sources PubMed and Web of Science were searched for eligible observational studies until 31st March, 2023. Data extraction The meta-analysis was conducted by pooling relative risk (RR), odds ratio (OR) or hazards ratio (HR) with 95% confidence intervals (CIs). Potential sources of heterogeneity were detected by subgroup analysis. Sensitivity analysis and publication bias test were also carried out. Data analysis Through stepwise screening, a total of 27 studies were included. The pooled estimates of liver cancer for whole grains and legumes intake were 0.66 (95% CI: 0.54–0.82; I 2 = 25.3%) and 0.86 (95% CI: 0.75–0.99; I 2 = 14.3%), respectively. However, there were null associations of nuts, poultry, egg and sweetened beverages consumption with liver cancer and the association between refined grains and liver cancer was inconclusive. In dose-response meta-analysis, the pooled estimates of liver cancer were 0.77 (95% CI: 0.65–0.91) for every 50 g/day increment in whole grains intake. Non-linear dose-response relationship (P = 0.031) was observed in the association between the intake of legumes and liver cancer, and the protective effect occurred with the dose ranging from 8 g/day to 40 g/day. Conclusions This meta-analysis shows that whole grains and legumes were inversely associated with liver cancer, whereas intake of nuts, poultry, egg and sweetened beverages may not be associated with liver cancer. Further quantitative research needs to be undertaken within a range of populations to investigate the relationship between food groups and liver cancer. Systematic review registration PROSPERO registration no. CRD42021246142 |
| first_indexed | 2024-03-13T03:24:14Z |
| format | Article |
| id | doaj.art-75db60f03dc24e0c87d2fcd66482c001 |
| institution | Directory Open Access Journal |
| issn | 1475-2891 |
| language | English |
| last_indexed | 2024-03-13T03:24:14Z |
| publishDate | 2023-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Nutrition Journal |
| spelling | doaj.art-75db60f03dc24e0c87d2fcd66482c0012023-06-25T11:09:46ZengBMCNutrition Journal1475-28912023-06-0122111210.1186/s12937-023-00858-5Associations between food groups and liver cancer: a systematic review and meta-analysis of observational studiesKe Liu0Weiwei Chen1Yi Zhou2Liuhong Xu3Xiaohui Sun4Yingying Mao5Ding Ye6Department of Epidemiology, School of Public Health, Zhejiang Chinese Medical UniversityDepartment of Epidemiology, School of Public Health, Zhejiang Chinese Medical UniversityDepartment of Epidemiology, School of Public Health, Zhejiang Chinese Medical UniversityDepartment of Epidemiology, School of Public Health, Zhejiang Chinese Medical UniversityDepartment of Epidemiology, School of Public Health, Zhejiang Chinese Medical UniversityDepartment of Epidemiology, School of Public Health, Zhejiang Chinese Medical UniversityDepartment of Epidemiology, School of Public Health, Zhejiang Chinese Medical UniversityAbstract Context Diet is emerging as a modifiable component of lifestyle for influencing the incidence of liver cancer. Objective To investigate and quantify the potential relationship between food groups and liver cancer. Data sources PubMed and Web of Science were searched for eligible observational studies until 31st March, 2023. Data extraction The meta-analysis was conducted by pooling relative risk (RR), odds ratio (OR) or hazards ratio (HR) with 95% confidence intervals (CIs). Potential sources of heterogeneity were detected by subgroup analysis. Sensitivity analysis and publication bias test were also carried out. Data analysis Through stepwise screening, a total of 27 studies were included. The pooled estimates of liver cancer for whole grains and legumes intake were 0.66 (95% CI: 0.54–0.82; I 2 = 25.3%) and 0.86 (95% CI: 0.75–0.99; I 2 = 14.3%), respectively. However, there were null associations of nuts, poultry, egg and sweetened beverages consumption with liver cancer and the association between refined grains and liver cancer was inconclusive. In dose-response meta-analysis, the pooled estimates of liver cancer were 0.77 (95% CI: 0.65–0.91) for every 50 g/day increment in whole grains intake. Non-linear dose-response relationship (P = 0.031) was observed in the association between the intake of legumes and liver cancer, and the protective effect occurred with the dose ranging from 8 g/day to 40 g/day. Conclusions This meta-analysis shows that whole grains and legumes were inversely associated with liver cancer, whereas intake of nuts, poultry, egg and sweetened beverages may not be associated with liver cancer. Further quantitative research needs to be undertaken within a range of populations to investigate the relationship between food groups and liver cancer. Systematic review registration PROSPERO registration no. CRD42021246142https://doi.org/10.1186/s12937-023-00858-5Liver cancerFood groupsMeta-analysisDose-response |
| spellingShingle | Ke Liu Weiwei Chen Yi Zhou Liuhong Xu Xiaohui Sun Yingying Mao Ding Ye Associations between food groups and liver cancer: a systematic review and meta-analysis of observational studies Nutrition Journal Liver cancer Food groups Meta-analysis Dose-response |
| title | Associations between food groups and liver cancer: a systematic review and meta-analysis of observational studies |
| title_full | Associations between food groups and liver cancer: a systematic review and meta-analysis of observational studies |
| title_fullStr | Associations between food groups and liver cancer: a systematic review and meta-analysis of observational studies |
| title_full_unstemmed | Associations between food groups and liver cancer: a systematic review and meta-analysis of observational studies |
| title_short | Associations between food groups and liver cancer: a systematic review and meta-analysis of observational studies |
| title_sort | associations between food groups and liver cancer a systematic review and meta analysis of observational studies |
| topic | Liver cancer Food groups Meta-analysis Dose-response |
| url | https://doi.org/10.1186/s12937-023-00858-5 |
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