Protective Effect of Avenanthramide-C on Auditory Hair Cells against Oxidative Stress, Inflammatory Cytokines, and DNA Damage in Cisplatin-Induced Ototoxicity

Protective Effect of Avenanthramide-C on Auditory Hair Cells against Oxidative Stress, Inflammatory Cytokines, and DNA Damage in Cisplatin-Induced Ototoxicity

Cisplatin-induced ototoxicity leads to hearing impairment, possibly through reactive oxygen species (ROS) production and DNA damage in cochlear hair cells (HC), although the exact mechanism is unknown. Avenanthramide-C (AVN-C), a natural, potent antioxidant, was evaluated in three study groups of no...

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Bibliographic Details
Main Authors: Alphonse Umugire, Yoon Seok Nam, Ye Eun Nam, Young Mi Choi, Se Myeong Choi, Sungsu Lee, Jong Hyun Cho, Hyong-Ho Cho
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:International Journal of Molecular Sciences
Subjects:
avenanthramide-C
cisplatin
DNA damage
ROS
hair cell loss
hearing loss
Online Access:https://www.mdpi.com/1422-0067/24/3/2947

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