Endophytic Fungi—Alternative Sources of Cytotoxic Compounds: A Review
Cancer is a major cause of death worldwide, with an increasing number of cases being reported annually. The elevated rate of mortality necessitates a global challenge to explore newer sources of anticancer drugs. Recent advancements in cancer treatment involve the discovery and development of new an...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-04-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fphar.2018.00309/full |
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| author | Fazilath Uzma Chakrabhavi D. Mohan Abeer Hashem Narasimha M. Konappa Shobith Rangappa Praveen V. Kamath Bhim P. Singh Venkataramana Mudili Vijai K. Gupta Chandra N. Siddaiah Srinivas Chowdappa Abdulaziz A. Alqarawi Elsayed F. Abd_Allah |
| author_facet | Fazilath Uzma Chakrabhavi D. Mohan Abeer Hashem Narasimha M. Konappa Shobith Rangappa Praveen V. Kamath Bhim P. Singh Venkataramana Mudili Vijai K. Gupta Chandra N. Siddaiah Srinivas Chowdappa Abdulaziz A. Alqarawi Elsayed F. Abd_Allah |
| author_sort | Fazilath Uzma |
| collection | DOAJ |
| description | Cancer is a major cause of death worldwide, with an increasing number of cases being reported annually. The elevated rate of mortality necessitates a global challenge to explore newer sources of anticancer drugs. Recent advancements in cancer treatment involve the discovery and development of new and improved chemotherapeutics derived from natural or synthetic sources. Natural sources offer the potential of finding new structural classes with unique bioactivities for cancer therapy. Endophytic fungi represent a rich source of bioactive metabolites that can be manipulated to produce desirable novel analogs for chemotherapy. This review offers a current and integrative account of clinically used anticancer drugs such as taxol, podophyllotoxin, camptothecin, and vinca alkaloids in terms of their mechanism of action, isolation from endophytic fungi and their characterization, yield obtained, and fungal strain improvement strategies. It also covers recent literature on endophytic fungal metabolites from terrestrial, mangrove, and marine sources as potential anticancer agents and emphasizes the findings for cytotoxic bioactive compounds tested against specific cancer cell lines. |
| first_indexed | 2024-04-12T00:46:12Z |
| format | Article |
| id | doaj.art-75dcb68534c84392b5c0d3dfd71fb4a4 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-12T00:46:12Z |
| publishDate | 2018-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-75dcb68534c84392b5c0d3dfd71fb4a42022-12-22T03:54:52ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122018-04-01910.3389/fphar.2018.00309328484Endophytic Fungi—Alternative Sources of Cytotoxic Compounds: A ReviewFazilath Uzma0Chakrabhavi D. Mohan1Abeer Hashem2Narasimha M. Konappa3Shobith Rangappa4Praveen V. Kamath5Bhim P. Singh6Venkataramana Mudili7Vijai K. Gupta8Chandra N. Siddaiah9Srinivas Chowdappa10Abdulaziz A. Alqarawi11Elsayed F. Abd_Allah12Microbial Metabolite Research Laboratory, Department of Microbiology and Biotechnology, Bangalore University, Bangalore, IndiaDepartment of Studies in Molecular Biology, University of Mysore, Mysore, IndiaBotany and Microbiology Department, College of Science, King Saud University, Riyadh, Saudi ArabiaDepartment of Studies in Biotechnology, University of Mysore, Mysore, IndiaAdichunchanagiri Institute for Molecular Medicine, BG Nagara, Mandya, IndiaMicrobial Metabolite Research Laboratory, Department of Microbiology and Biotechnology, Bangalore University, Bangalore, IndiaMolecular Microbiology and Systematics Laboratory, Department of Biotechnology, Mizoram University, Aizawl, IndiaMicrobiology Division, DRDO-BU-Centre for Life sciences, Bharathiar University, Coimbatore, IndiaDepartment of Chemistry and Biotechnology, ERA Chair of Green Chemistry, School of Science, Tallinn University of Technology, Tallinn, EstoniaDepartment of Studies in Biotechnology, University of Mysore, Mysore, IndiaMicrobial Metabolite Research Laboratory, Department of Microbiology and Biotechnology, Bangalore University, Bangalore, IndiaPlant Production Department, College of Food and Agricultural Sciences, King Saud University, Riyadh, Saudi ArabiaPlant Production Department, College of Food and Agricultural Sciences, King Saud University, Riyadh, Saudi ArabiaCancer is a major cause of death worldwide, with an increasing number of cases being reported annually. The elevated rate of mortality necessitates a global challenge to explore newer sources of anticancer drugs. Recent advancements in cancer treatment involve the discovery and development of new and improved chemotherapeutics derived from natural or synthetic sources. Natural sources offer the potential of finding new structural classes with unique bioactivities for cancer therapy. Endophytic fungi represent a rich source of bioactive metabolites that can be manipulated to produce desirable novel analogs for chemotherapy. This review offers a current and integrative account of clinically used anticancer drugs such as taxol, podophyllotoxin, camptothecin, and vinca alkaloids in terms of their mechanism of action, isolation from endophytic fungi and their characterization, yield obtained, and fungal strain improvement strategies. It also covers recent literature on endophytic fungal metabolites from terrestrial, mangrove, and marine sources as potential anticancer agents and emphasizes the findings for cytotoxic bioactive compounds tested against specific cancer cell lines.http://journal.frontiersin.org/article/10.3389/fphar.2018.00309/fullbioactive metabolitesanticancer agentsnatural compoundsfungal alkaloidstaxolpodophyllotoxin |
| spellingShingle | Fazilath Uzma Chakrabhavi D. Mohan Abeer Hashem Narasimha M. Konappa Shobith Rangappa Praveen V. Kamath Bhim P. Singh Venkataramana Mudili Vijai K. Gupta Chandra N. Siddaiah Srinivas Chowdappa Abdulaziz A. Alqarawi Elsayed F. Abd_Allah Endophytic Fungi—Alternative Sources of Cytotoxic Compounds: A Review Frontiers in Pharmacology bioactive metabolites anticancer agents natural compounds fungal alkaloids taxol podophyllotoxin |
| title | Endophytic Fungi—Alternative Sources of Cytotoxic Compounds: A Review |
| title_full | Endophytic Fungi—Alternative Sources of Cytotoxic Compounds: A Review |
| title_fullStr | Endophytic Fungi—Alternative Sources of Cytotoxic Compounds: A Review |
| title_full_unstemmed | Endophytic Fungi—Alternative Sources of Cytotoxic Compounds: A Review |
| title_short | Endophytic Fungi—Alternative Sources of Cytotoxic Compounds: A Review |
| title_sort | endophytic fungi alternative sources of cytotoxic compounds a review |
| topic | bioactive metabolites anticancer agents natural compounds fungal alkaloids taxol podophyllotoxin |
| url | http://journal.frontiersin.org/article/10.3389/fphar.2018.00309/full |
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