Third harmonic generation imaging and analysis of the effect of low gravity on the lacuno-canalicular network of mouse bone.

The lacuno-canalicular network (LCN) hosting the osteocytes in bone tissue represents a biological signature of the mechanotransduction activity in response to external biomechanical loading. Using third-harmonic generation (THG) microscopy with sub-micrometer resolution, we investigate the impact o...

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Bibliographic Details
Main Authors: Rachel Genthial, Maude Gerbaix, Delphine Farlay, Laurence Vico, Emmanuel Beaurepaire, Delphine Débarre, Aurélien Gourrier
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0209079