Impact of DNA damage repair alterations on prostate cancer progression and metastasis
Prostate cancer is among the most common diseases worldwide. Despite recent progress with treatments, patients with advanced prostate cancer have poor outcomes and there is a high unmet need in this population. Understanding molecular determinants underlying prostate cancer and the aggressive phenot...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-06-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2023.1162644/full |
| _version_ | 1797795117703102464 |
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| author | Natalia Lukashchuk Alan Barnicle Carrie A. Adelman Joshua Armenia Jinyu Kang J. Carl Barrett Elizabeth A. Harrington |
| author_facet | Natalia Lukashchuk Alan Barnicle Carrie A. Adelman Joshua Armenia Jinyu Kang J. Carl Barrett Elizabeth A. Harrington |
| author_sort | Natalia Lukashchuk |
| collection | DOAJ |
| description | Prostate cancer is among the most common diseases worldwide. Despite recent progress with treatments, patients with advanced prostate cancer have poor outcomes and there is a high unmet need in this population. Understanding molecular determinants underlying prostate cancer and the aggressive phenotype of disease can help with design of better clinical trials and improve treatments for these patients. One of the pathways often altered in advanced prostate cancer is DNA damage response (DDR), including alterations in BRCA1/2 and other homologous recombination repair (HRR) genes. Alterations in the DDR pathway are particularly prevalent in metastatic prostate cancer. In this review, we summarise the prevalence of DDR alterations in primary and advanced prostate cancer and discuss the impact of alterations in the DDR pathway on aggressive disease phenotype, prognosis and the association of germline pathogenic1 alterations in DDR genes with risk of developing prostate cancer. |
| first_indexed | 2024-03-13T03:13:03Z |
| format | Article |
| id | doaj.art-75ddc3fc85e340e5abec988d20c8dc6f |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-03-13T03:13:03Z |
| publishDate | 2023-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-75ddc3fc85e340e5abec988d20c8dc6f2023-06-26T10:04:17ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-06-011310.3389/fonc.2023.11626441162644Impact of DNA damage repair alterations on prostate cancer progression and metastasisNatalia Lukashchuk0Alan Barnicle1Carrie A. Adelman2Joshua Armenia3Jinyu Kang4J. Carl Barrett5Elizabeth A. Harrington6Translational Medicine, Oncology Research and Development (R&D), AstraZeneca, Cambridge, United KingdomTranslational Medicine, Oncology Research and Development (R&D), AstraZeneca, Cambridge, United KingdomTranslational Medicine, Oncology Research and Development (R&D), AstraZeneca, Cambridge, United KingdomOncology Data Science, Oncology Research and Development (R&D), AstraZeneca, Cambridge, United KingdomGlobal Medicines Development, Oncology Research and Development (R&D), AstraZeneca, Gaithersburg, MD, United StatesTranslational Medicine, Oncology Research and Development (R&D), AstraZeneca, Waltham, MA, United StatesTranslational Medicine, Oncology Research and Development (R&D), AstraZeneca, Cambridge, United KingdomProstate cancer is among the most common diseases worldwide. Despite recent progress with treatments, patients with advanced prostate cancer have poor outcomes and there is a high unmet need in this population. Understanding molecular determinants underlying prostate cancer and the aggressive phenotype of disease can help with design of better clinical trials and improve treatments for these patients. One of the pathways often altered in advanced prostate cancer is DNA damage response (DDR), including alterations in BRCA1/2 and other homologous recombination repair (HRR) genes. Alterations in the DDR pathway are particularly prevalent in metastatic prostate cancer. In this review, we summarise the prevalence of DDR alterations in primary and advanced prostate cancer and discuss the impact of alterations in the DDR pathway on aggressive disease phenotype, prognosis and the association of germline pathogenic1 alterations in DDR genes with risk of developing prostate cancer.https://www.frontiersin.org/articles/10.3389/fonc.2023.1162644/fullDNA damage responsehomologous recombination repairalterationsprognosisprostate cancer |
| spellingShingle | Natalia Lukashchuk Alan Barnicle Carrie A. Adelman Joshua Armenia Jinyu Kang J. Carl Barrett Elizabeth A. Harrington Impact of DNA damage repair alterations on prostate cancer progression and metastasis Frontiers in Oncology DNA damage response homologous recombination repair alterations prognosis prostate cancer |
| title | Impact of DNA damage repair alterations on prostate cancer progression and metastasis |
| title_full | Impact of DNA damage repair alterations on prostate cancer progression and metastasis |
| title_fullStr | Impact of DNA damage repair alterations on prostate cancer progression and metastasis |
| title_full_unstemmed | Impact of DNA damage repair alterations on prostate cancer progression and metastasis |
| title_short | Impact of DNA damage repair alterations on prostate cancer progression and metastasis |
| title_sort | impact of dna damage repair alterations on prostate cancer progression and metastasis |
| topic | DNA damage response homologous recombination repair alterations prognosis prostate cancer |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2023.1162644/full |
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