NLRP3 Inflammasome Activates Endothelial-to-Mesenchymal Transition via Focal Adhesion Kinase Pathway in Bleomycin-Induced Pulmonary Fibrosis

NLRP3 Inflammasome Activates Endothelial-to-Mesenchymal Transition via Focal Adhesion Kinase Pathway in Bleomycin-Induced Pulmonary Fibrosis

Idiopathic pulmonary fibrosis has poor clinical outcomes despite antifibrotic treatment. The nucleotide-binding domain leucine-rich repeat-containing receptor, pyrin domain-containing-3 (NLRP3) inflammasome and endothelial-to-mesenchymal transition (EndoMT) were shown to be involved in the pathogene...

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Bibliographic Details
Main Authors: Wei-Chih Chen, Wen-Kuang Yu, Vincent Yi-Fong Su, Han-Shui Hsu, Kuang-Yao Yang
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:International Journal of Molecular Sciences
Subjects:
nucleotide-binding domain leucine-rich repeat-containing receptor
pyrin domain-containing-3 (NLRP3) inflammasome
endothelial-to-mesenchymal transition
focal adhesion kinase
caspase-1 inhibitor
pulmonary fibrosis
Online Access:https://www.mdpi.com/1422-0067/24/21/15813

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