Prognostic Value of Volume-Based Positron Emission Tomography/Computed Tomography in Patients With Nasopharyngeal Carcinoma Treated With Concurrent Chemoradiotherapy
ObjectivesThe aim of this study was to evaluate the prognostic value of volume-based metabolic parameters measured by 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) in patients with nasopharyngeal carcinoma (NPC).MethodsForty-four NPC patients who underwent 18F-FDG PET/CT for init...
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| Format: | Article |
| Language: | English |
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Korean Society of Otorhinolaryngology-Head and Neck Surgery
2015-06-01
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| Series: | Clinical and Experimental Otorhinolaryngology |
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| Online Access: | http://www.e-ceo.org/upload/pdf/ceo-8-142.pdf |
| _version_ | 1818518249694822400 |
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| author | Seung Hwan Moon Joon Young Choi Hwan Joo Lee Young-Ik Son Chung-Hwan Baek Yong Chan Ahn Myung-Ju Ahn Keunchil Park Byung-Tae Kim |
| author_facet | Seung Hwan Moon Joon Young Choi Hwan Joo Lee Young-Ik Son Chung-Hwan Baek Yong Chan Ahn Myung-Ju Ahn Keunchil Park Byung-Tae Kim |
| author_sort | Seung Hwan Moon |
| collection | DOAJ |
| description | ObjectivesThe aim of this study was to evaluate the prognostic value of volume-based metabolic parameters measured by 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) in patients with nasopharyngeal carcinoma (NPC).MethodsForty-four NPC patients who underwent 18F-FDG PET/CT for initial staging work-up before concurrent chemoradiotherapy (CCRT) were retrospectively evaluated. Maximum standardized uptake value (SUV), mean SUV, metabolic tumor volume (MTV), and total lesion glycolysis (TLG) of the primary tumors were measured. The prognostic significance and predictive performance of these parameters were assessed by Cox proportional hazards regression analysis and time-dependent receiver operating characteristics (ROC) curve analysis.ResultsMultivariate analysis showed that American Joint Committee on Cancer stage 7th edition (hazard ratio [HR], 1.525; 95% confidence interval [CI], 1.062 to 2.188; P=0.022), and TLG (HR, 7.799; 95% CI, 2.622 to 23.198; P≤0.001) were independent predictive factors associated with decreased disease-free survival (DFS). Time-dependent ROC curve analysis indicated that TLG was a better predictor of DFS than MTV (P=0.008).ConclusionThe TLG of the primary tumor was a significant independent metabolic prognostic factor of DFS in patients with NPC treated with CCRT. |
| first_indexed | 2024-12-11T01:07:25Z |
| format | Article |
| id | doaj.art-75e1d18a080a411a8a716ef2256c2a38 |
| institution | Directory Open Access Journal |
| issn | 1976-8710 2005-0720 |
| language | English |
| last_indexed | 2024-12-11T01:07:25Z |
| publishDate | 2015-06-01 |
| publisher | Korean Society of Otorhinolaryngology-Head and Neck Surgery |
| record_format | Article |
| series | Clinical and Experimental Otorhinolaryngology |
| spelling | doaj.art-75e1d18a080a411a8a716ef2256c2a382022-12-22T01:26:08ZengKorean Society of Otorhinolaryngology-Head and Neck SurgeryClinical and Experimental Otorhinolaryngology1976-87102005-07202015-06-018214214810.3342/ceo.2015.8.2.142355Prognostic Value of Volume-Based Positron Emission Tomography/Computed Tomography in Patients With Nasopharyngeal Carcinoma Treated With Concurrent ChemoradiotherapySeung Hwan Moon0Joon Young Choi1Hwan Joo Lee2Young-Ik Son3Chung-Hwan Baek4Yong Chan Ahn5Myung-Ju Ahn6Keunchil Park7Byung-Tae Kim8Department of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.Department of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.Department of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.Department of Otorhinolaryngology-Head and Neck Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.Department of Otorhinolaryngology-Head and Neck Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.Department of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.Department of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.ObjectivesThe aim of this study was to evaluate the prognostic value of volume-based metabolic parameters measured by 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) in patients with nasopharyngeal carcinoma (NPC).MethodsForty-four NPC patients who underwent 18F-FDG PET/CT for initial staging work-up before concurrent chemoradiotherapy (CCRT) were retrospectively evaluated. Maximum standardized uptake value (SUV), mean SUV, metabolic tumor volume (MTV), and total lesion glycolysis (TLG) of the primary tumors were measured. The prognostic significance and predictive performance of these parameters were assessed by Cox proportional hazards regression analysis and time-dependent receiver operating characteristics (ROC) curve analysis.ResultsMultivariate analysis showed that American Joint Committee on Cancer stage 7th edition (hazard ratio [HR], 1.525; 95% confidence interval [CI], 1.062 to 2.188; P=0.022), and TLG (HR, 7.799; 95% CI, 2.622 to 23.198; P≤0.001) were independent predictive factors associated with decreased disease-free survival (DFS). Time-dependent ROC curve analysis indicated that TLG was a better predictor of DFS than MTV (P=0.008).ConclusionThe TLG of the primary tumor was a significant independent metabolic prognostic factor of DFS in patients with NPC treated with CCRT.http://www.e-ceo.org/upload/pdf/ceo-8-142.pdfFluorodeoxyglucose F18Positron-Emission TomographyNasopharyngeal CarcinomaTumor BurdenPrognosis |
| spellingShingle | Seung Hwan Moon Joon Young Choi Hwan Joo Lee Young-Ik Son Chung-Hwan Baek Yong Chan Ahn Myung-Ju Ahn Keunchil Park Byung-Tae Kim Prognostic Value of Volume-Based Positron Emission Tomography/Computed Tomography in Patients With Nasopharyngeal Carcinoma Treated With Concurrent Chemoradiotherapy Clinical and Experimental Otorhinolaryngology Fluorodeoxyglucose F18 Positron-Emission Tomography Nasopharyngeal Carcinoma Tumor Burden Prognosis |
| title | Prognostic Value of Volume-Based Positron Emission Tomography/Computed Tomography in Patients With Nasopharyngeal Carcinoma Treated With Concurrent Chemoradiotherapy |
| title_full | Prognostic Value of Volume-Based Positron Emission Tomography/Computed Tomography in Patients With Nasopharyngeal Carcinoma Treated With Concurrent Chemoradiotherapy |
| title_fullStr | Prognostic Value of Volume-Based Positron Emission Tomography/Computed Tomography in Patients With Nasopharyngeal Carcinoma Treated With Concurrent Chemoradiotherapy |
| title_full_unstemmed | Prognostic Value of Volume-Based Positron Emission Tomography/Computed Tomography in Patients With Nasopharyngeal Carcinoma Treated With Concurrent Chemoradiotherapy |
| title_short | Prognostic Value of Volume-Based Positron Emission Tomography/Computed Tomography in Patients With Nasopharyngeal Carcinoma Treated With Concurrent Chemoradiotherapy |
| title_sort | prognostic value of volume based positron emission tomography computed tomography in patients with nasopharyngeal carcinoma treated with concurrent chemoradiotherapy |
| topic | Fluorodeoxyglucose F18 Positron-Emission Tomography Nasopharyngeal Carcinoma Tumor Burden Prognosis |
| url | http://www.e-ceo.org/upload/pdf/ceo-8-142.pdf |
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