Loss of Caveolin 1 is Associated With the Expression of Aquaporin 1 and Bladder Dysfunction in Mice
Purpose: It is suggested that caveolin and aquaporin might be closely associated with bladder signal activity. We investigated the effect of the deletion of caveolin 1, using caveolin 1 knockout mice, on the expression of aquaporin 1 in order to identify their relation in the urothelium of the urina...
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| Format: | Article |
| Language: | English |
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Korean Continence Society
2015-03-01
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| Series: | International Neurourology Journal |
| Subjects: | |
| Online Access: | http://www.einj.org/upload/pdf/inj-19-1-34.pdf |
| _version_ | 1818193486949646336 |
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| author | Seheon Jung Sun-Ouck Kim Kyung-Aa Cho Seung Hee Song Teak Won Kang Kwangsung Park Dongdeuk Kwon |
| author_facet | Seheon Jung Sun-Ouck Kim Kyung-Aa Cho Seung Hee Song Teak Won Kang Kwangsung Park Dongdeuk Kwon |
| author_sort | Seheon Jung |
| collection | DOAJ |
| description | Purpose: It is suggested that caveolin and aquaporin might be closely associated with bladder signal activity. We investigated the effect of the deletion of caveolin 1, using caveolin 1 knockout mice, on the expression of aquaporin 1 in order to identify their relation in the urothelium of the urinary bladder. Methods: The cellular localization and expressions of aquaporin 1 and caveolin 1, in the wild type and caveolin 1 knockout mice urinary bladder, were examined by Western blot and immunofluorescence techniques. Results: Aquaporin 1 and caveolin 1 were coexpressed in the arterioles, venules, and capillaries of the suburothelial layer in the wild type controls. Aquaporin 1 protein expression was significantly higher in the caveolin 1 knockout mice than in the wild type controls (P <0.05). Conclusions: The results imply that aquaporin 1 and caveolin 1 may share a distinct relation with the bladder signal activity. This might play a specific role in bladder dysfunction. |
| first_indexed | 2024-12-12T00:47:10Z |
| format | Article |
| id | doaj.art-75e3611a321f46a59a6f5997cac00112 |
| institution | Directory Open Access Journal |
| issn | 2093-4777 2093-6931 |
| language | English |
| last_indexed | 2024-12-12T00:47:10Z |
| publishDate | 2015-03-01 |
| publisher | Korean Continence Society |
| record_format | Article |
| series | International Neurourology Journal |
| spelling | doaj.art-75e3611a321f46a59a6f5997cac001122022-12-22T00:44:06ZengKorean Continence SocietyInternational Neurourology Journal2093-47772093-69312015-03-01191343810.5213/inj.2015.19.1.34517Loss of Caveolin 1 is Associated With the Expression of Aquaporin 1 and Bladder Dysfunction in MiceSeheon Jung0Sun-Ouck Kim1Kyung-Aa Cho2Seung Hee Song3Teak Won Kang4Kwangsung Park5Dongdeuk Kwon6 Department of Urology, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Korea Department of Urology, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Korea Department of Biochemistry, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Korea Department of Urology, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Korea Department of Urology, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Korea Department of Urology, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Korea Department of Urology, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, KoreaPurpose: It is suggested that caveolin and aquaporin might be closely associated with bladder signal activity. We investigated the effect of the deletion of caveolin 1, using caveolin 1 knockout mice, on the expression of aquaporin 1 in order to identify their relation in the urothelium of the urinary bladder. Methods: The cellular localization and expressions of aquaporin 1 and caveolin 1, in the wild type and caveolin 1 knockout mice urinary bladder, were examined by Western blot and immunofluorescence techniques. Results: Aquaporin 1 and caveolin 1 were coexpressed in the arterioles, venules, and capillaries of the suburothelial layer in the wild type controls. Aquaporin 1 protein expression was significantly higher in the caveolin 1 knockout mice than in the wild type controls (P <0.05). Conclusions: The results imply that aquaporin 1 and caveolin 1 may share a distinct relation with the bladder signal activity. This might play a specific role in bladder dysfunction.http://www.einj.org/upload/pdf/inj-19-1-34.pdfAquaporin 1Caveolin 1Bladder |
| spellingShingle | Seheon Jung Sun-Ouck Kim Kyung-Aa Cho Seung Hee Song Teak Won Kang Kwangsung Park Dongdeuk Kwon Loss of Caveolin 1 is Associated With the Expression of Aquaporin 1 and Bladder Dysfunction in Mice International Neurourology Journal Aquaporin 1 Caveolin 1 Bladder |
| title | Loss of Caveolin 1 is Associated With the Expression of Aquaporin 1 and Bladder Dysfunction in Mice |
| title_full | Loss of Caveolin 1 is Associated With the Expression of Aquaporin 1 and Bladder Dysfunction in Mice |
| title_fullStr | Loss of Caveolin 1 is Associated With the Expression of Aquaporin 1 and Bladder Dysfunction in Mice |
| title_full_unstemmed | Loss of Caveolin 1 is Associated With the Expression of Aquaporin 1 and Bladder Dysfunction in Mice |
| title_short | Loss of Caveolin 1 is Associated With the Expression of Aquaporin 1 and Bladder Dysfunction in Mice |
| title_sort | loss of caveolin 1 is associated with the expression of aquaporin 1 and bladder dysfunction in mice |
| topic | Aquaporin 1 Caveolin 1 Bladder |
| url | http://www.einj.org/upload/pdf/inj-19-1-34.pdf |
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