Ocular Paraneoplastic Syndromes
Ocular-involving paraneoplastic syndromes present a wide variety of clinical symptoms. Understanding the background pathophysiological and immunopathological factors can help make a more refined differential diagnosis consistent with the signs and symptoms presented by patients. There are two main p...
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MDPI AG
2020-11-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/8/11/490 |
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| author | Joanna Przeździecka-Dołyk Anna Brzecka Maria Ejma Marta Misiuk-Hojło Luis Fernando Torres Solis Arturo Solís Herrera Siva G. Somasundaram Cecil E. Kirkland Gjumrakch Aliev |
| author_facet | Joanna Przeździecka-Dołyk Anna Brzecka Maria Ejma Marta Misiuk-Hojło Luis Fernando Torres Solis Arturo Solís Herrera Siva G. Somasundaram Cecil E. Kirkland Gjumrakch Aliev |
| author_sort | Joanna Przeździecka-Dołyk |
| collection | DOAJ |
| description | Ocular-involving paraneoplastic syndromes present a wide variety of clinical symptoms. Understanding the background pathophysiological and immunopathological factors can help make a more refined differential diagnosis consistent with the signs and symptoms presented by patients. There are two main pathophysiology arms: (1) autoimmune pathomechanism, which is presented with cancer-associated retinopathy (CAR), melanoma-associated retinopathy (MAR), cancer-associated cone dysfunction (CACD), paraneoplastic vitelliform maculopathy (PVM), and paraneoplastic optic neuritis (PON), and (2) ectopic peptides, which is often caused by tumor-expressed growth factors (T-exGF) and presented with bilateral diffuse uveal melanocytic proliferation (BDUMP). Meticulous systematic analysis of patient symptoms is a critical diagnostic step, complemented by multimodal imaging, which includes fundus photography, optical coherent tomography, fundus autofluorescence, fundus fluorescein angiography, electrophysiological examination, and sometimes fundus indocyjanin green angiography if prescribed by the clinician. Assessment of the presence of circulating antibodies is required for diagnosis. Antiretinal autoantibodies are highly associated with visual paraneoplastic syndromes and may guide diagnosis by classifying clinical manifestations in addition to monitoring treatment. |
| first_indexed | 2024-03-10T14:57:54Z |
| format | Article |
| id | doaj.art-75e46fd0aa004df5888a454d096dcc73 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T14:57:54Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-75e46fd0aa004df5888a454d096dcc732023-11-20T20:26:30ZengMDPI AGBiomedicines2227-90592020-11-0181149010.3390/biomedicines8110490Ocular Paraneoplastic SyndromesJoanna Przeździecka-Dołyk0Anna Brzecka1Maria Ejma2Marta Misiuk-Hojło3Luis Fernando Torres Solis4Arturo Solís Herrera5Siva G. Somasundaram6Cecil E. Kirkland7Gjumrakch Aliev8Department of Ophthalmology, Wroclaw Medical University, Borowska 213, 50-556 Wrocław, PolandDepartment of Pulmonology and Lung Oncology, Wrocław Medical University, Grabiszyńska 105, 53-439 Wrocław, PolandDepartment of Neurology, Wroclaw Medical University, Borowska 213, 50-556 Wrocław, PolandDepartment of Ophthalmology, Wroclaw Medical University, Borowska 213, 50-556 Wrocław, PolandThe School of Medicine, Universidad Autónoma de Aguascalientes, Aguascalientes 20392, MexicoHuman Photosynthesis© Research Centre, Aguascalientes 20000, MexicoDepartment of Biological Sciences, Salem University, Salem, WV 26426, USADepartment of Biological Sciences, Salem University, Salem, WV 26426, USASechenov First Moscow State Medical University (Sechenov University), St. Trubetskaya, 8, bld. 2, 119991 Moscow, RussiaOcular-involving paraneoplastic syndromes present a wide variety of clinical symptoms. Understanding the background pathophysiological and immunopathological factors can help make a more refined differential diagnosis consistent with the signs and symptoms presented by patients. There are two main pathophysiology arms: (1) autoimmune pathomechanism, which is presented with cancer-associated retinopathy (CAR), melanoma-associated retinopathy (MAR), cancer-associated cone dysfunction (CACD), paraneoplastic vitelliform maculopathy (PVM), and paraneoplastic optic neuritis (PON), and (2) ectopic peptides, which is often caused by tumor-expressed growth factors (T-exGF) and presented with bilateral diffuse uveal melanocytic proliferation (BDUMP). Meticulous systematic analysis of patient symptoms is a critical diagnostic step, complemented by multimodal imaging, which includes fundus photography, optical coherent tomography, fundus autofluorescence, fundus fluorescein angiography, electrophysiological examination, and sometimes fundus indocyjanin green angiography if prescribed by the clinician. Assessment of the presence of circulating antibodies is required for diagnosis. Antiretinal autoantibodies are highly associated with visual paraneoplastic syndromes and may guide diagnosis by classifying clinical manifestations in addition to monitoring treatment.https://www.mdpi.com/2227-9059/8/11/490cancer-associated retinopathymelanoma-associated retinopathycancer-associated cone dysfunctionparaneoplastic syndromesvitelliform maculopathyoptic neuritis |
| spellingShingle | Joanna Przeździecka-Dołyk Anna Brzecka Maria Ejma Marta Misiuk-Hojło Luis Fernando Torres Solis Arturo Solís Herrera Siva G. Somasundaram Cecil E. Kirkland Gjumrakch Aliev Ocular Paraneoplastic Syndromes Biomedicines cancer-associated retinopathy melanoma-associated retinopathy cancer-associated cone dysfunction paraneoplastic syndromes vitelliform maculopathy optic neuritis |
| title | Ocular Paraneoplastic Syndromes |
| title_full | Ocular Paraneoplastic Syndromes |
| title_fullStr | Ocular Paraneoplastic Syndromes |
| title_full_unstemmed | Ocular Paraneoplastic Syndromes |
| title_short | Ocular Paraneoplastic Syndromes |
| title_sort | ocular paraneoplastic syndromes |
| topic | cancer-associated retinopathy melanoma-associated retinopathy cancer-associated cone dysfunction paraneoplastic syndromes vitelliform maculopathy optic neuritis |
| url | https://www.mdpi.com/2227-9059/8/11/490 |
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