The MAPK and AMPK signalings: interplay and implication in targeted cancer therapy

The MAPK and AMPK signalings: interplay and implication in targeted cancer therapy

Abstract Cancer is characterized as a complex disease caused by coordinated alterations of multiple signaling pathways. The Ras/RAF/MEK/ERK (MAPK) signaling is one of the best-defined pathways in cancer biology, and its hyperactivation is responsible for over 40% human cancer cases. To drive carcino...

Full description

Bibliographic Details
Main Authors: Jimin Yuan, Xiaoduo Dong, Jiajun Yap, Jiancheng Hu
Format: Article
Language:English
Published: BMC 2020-08-01
Series:Journal of Hematology & Oncology
Subjects:
Ras/RAF/MEK/ERK signaling
AMPK signaling
Interplay
Tumorigenesis
Cellular metabolism
RAF/MEK/ERK inhibitors
Online Access:http://link.springer.com/article/10.1186/s13045-020-00949-4

Similar Items

Similar Items