A single bout of moderate-intensity aerobic exercise improves motor learning in premanifest and early Huntington’s disease
IntroductionCardiorespiratory exercise has emerged as a promising candidate to modify disease progression in Huntington’s disease (HD). In animal models, exercise has been found to alter biomarkers of neuroplasticity and delay evidence of disease, and some interventions–including exercise–have shown...
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Psychology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyg.2023.1089333/full |
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| author | Sophie C. Andrews Sophie C. Andrews Lydia Kämpf Lydia Kämpf Dylan Curtin Mark Hinder Nicole Wenderoth Nicole Wenderoth Nicole Wenderoth Julie C. Stout James P. Coxon |
| author_facet | Sophie C. Andrews Sophie C. Andrews Lydia Kämpf Lydia Kämpf Dylan Curtin Mark Hinder Nicole Wenderoth Nicole Wenderoth Nicole Wenderoth Julie C. Stout James P. Coxon |
| author_sort | Sophie C. Andrews |
| collection | DOAJ |
| description | IntroductionCardiorespiratory exercise has emerged as a promising candidate to modify disease progression in Huntington’s disease (HD). In animal models, exercise has been found to alter biomarkers of neuroplasticity and delay evidence of disease, and some interventions–including exercise–have shown benefits in human HD patients. In healthy human populations, increasing evidence suggests that even a single bout of exercise can improve motor learning. In this pilot study, we investigated the effect of a single bout of moderate intensity aerobic exercise on motor skill learning in presymptomatic and early manifest HD patients.MethodsParticipants were allocated to either an exercise (n = 10) or control (n = 10) group. They performed either 20 min of moderate intensity cycling or rest before practicing a novel motor task, the sequential visual isometric pinch force task (SVIPT). After 1 week, the retention of the SVIPT was measured in both groups.ResultsWe found that the exercise group performed significantly better during initial task acquisition. There were no significant differences in offline memory consolidation between groups, but total skill gain across both acquisition and retention sessions was greater in the group who exercised. The better performance of the exercise group was driven by improvements in accuracy, rather than speed.DiscussionWe have shown that a single bout of moderate intensity aerobic exercise can facilitate motor skill learning in people with HD gene-expansion. More research is needed to investigate the underlying neural mechanisms and to further explore the potential for neurocognitive and functional benefits of exercise for people with HD. |
| first_indexed | 2024-04-10T05:23:43Z |
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| institution | Directory Open Access Journal |
| issn | 1664-1078 |
| language | English |
| last_indexed | 2024-04-10T05:23:43Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychology |
| spelling | doaj.art-75e69fc47fc046d9be4cce78f52d7f9e2023-03-08T04:41:47ZengFrontiers Media S.A.Frontiers in Psychology1664-10782023-03-011410.3389/fpsyg.2023.10893331089333A single bout of moderate-intensity aerobic exercise improves motor learning in premanifest and early Huntington’s diseaseSophie C. Andrews0Sophie C. Andrews1Lydia Kämpf2Lydia Kämpf3Dylan Curtin4Mark Hinder5Nicole Wenderoth6Nicole Wenderoth7Nicole Wenderoth8Julie C. Stout9James P. Coxon10School of Psychological Sciences, Turner Institute for Brain and Mental Health, Monash University, Clayton, VIC, AustraliaHealthy Brain Ageing Research Group, Thompson Institute, University of the Sunshine Coast, Birtinya, QLD, AustraliaSchool of Psychological Sciences, Turner Institute for Brain and Mental Health, Monash University, Clayton, VIC, AustraliaNeural Control of Movement Lab, Department of Health Sciences and Technology, ETH Zürich, Zurich, SwitzerlandSchool of Psychological Sciences, Turner Institute for Brain and Mental Health, Monash University, Clayton, VIC, AustraliaSensorimotor Neuroscience and Ageing Research Group, School of Psychological Sciences, College of Health and Medicine, University of Tasmania, Hobart, TAS, AustraliaNeural Control of Movement Lab, Department of Health Sciences and Technology, ETH Zürich, Zurich, SwitzerlandNeuroscience Center Zurich (ZNZ), Federal Institute of Technology Zurich, University and Balgrist Hospital Zurich, University of Zurich, Zurich, SwitzerlandFuture Health Technologies, Singapore-ETH Centre, Campus for Research Excellence and Technological Enterprise (CREATE), Singapore, SingaporeSchool of Psychological Sciences, Turner Institute for Brain and Mental Health, Monash University, Clayton, VIC, AustraliaSchool of Psychological Sciences, Turner Institute for Brain and Mental Health, Monash University, Clayton, VIC, AustraliaIntroductionCardiorespiratory exercise has emerged as a promising candidate to modify disease progression in Huntington’s disease (HD). In animal models, exercise has been found to alter biomarkers of neuroplasticity and delay evidence of disease, and some interventions–including exercise–have shown benefits in human HD patients. In healthy human populations, increasing evidence suggests that even a single bout of exercise can improve motor learning. In this pilot study, we investigated the effect of a single bout of moderate intensity aerobic exercise on motor skill learning in presymptomatic and early manifest HD patients.MethodsParticipants were allocated to either an exercise (n = 10) or control (n = 10) group. They performed either 20 min of moderate intensity cycling or rest before practicing a novel motor task, the sequential visual isometric pinch force task (SVIPT). After 1 week, the retention of the SVIPT was measured in both groups.ResultsWe found that the exercise group performed significantly better during initial task acquisition. There were no significant differences in offline memory consolidation between groups, but total skill gain across both acquisition and retention sessions was greater in the group who exercised. The better performance of the exercise group was driven by improvements in accuracy, rather than speed.DiscussionWe have shown that a single bout of moderate intensity aerobic exercise can facilitate motor skill learning in people with HD gene-expansion. More research is needed to investigate the underlying neural mechanisms and to further explore the potential for neurocognitive and functional benefits of exercise for people with HD.https://www.frontiersin.org/articles/10.3389/fpsyg.2023.1089333/fullmotor skillsimplicit learningcardiovascular exercisepremanifest Huntington’s diseaseneuroplasticity |
| spellingShingle | Sophie C. Andrews Sophie C. Andrews Lydia Kämpf Lydia Kämpf Dylan Curtin Mark Hinder Nicole Wenderoth Nicole Wenderoth Nicole Wenderoth Julie C. Stout James P. Coxon A single bout of moderate-intensity aerobic exercise improves motor learning in premanifest and early Huntington’s disease Frontiers in Psychology motor skills implicit learning cardiovascular exercise premanifest Huntington’s disease neuroplasticity |
| title | A single bout of moderate-intensity aerobic exercise improves motor learning in premanifest and early Huntington’s disease |
| title_full | A single bout of moderate-intensity aerobic exercise improves motor learning in premanifest and early Huntington’s disease |
| title_fullStr | A single bout of moderate-intensity aerobic exercise improves motor learning in premanifest and early Huntington’s disease |
| title_full_unstemmed | A single bout of moderate-intensity aerobic exercise improves motor learning in premanifest and early Huntington’s disease |
| title_short | A single bout of moderate-intensity aerobic exercise improves motor learning in premanifest and early Huntington’s disease |
| title_sort | single bout of moderate intensity aerobic exercise improves motor learning in premanifest and early huntington s disease |
| topic | motor skills implicit learning cardiovascular exercise premanifest Huntington’s disease neuroplasticity |
| url | https://www.frontiersin.org/articles/10.3389/fpsyg.2023.1089333/full |
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