Relationship between Prognostic Stage in Breast Cancer and Fluorine-18 Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography
This retrospective study examined the relationship between the standardized uptake value max (SUVmax) of fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (<sup>18</sup>F-FDG PET/CT) and the prognostic stage of breast cancer. We examined 358 breast cancers i...
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MDPI AG
2021-07-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/10/14/3173 |
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| author | Mio Mori Tomoyuki Fujioka Kazunori Kubota Leona Katsuta Yuka Yashima Kyoko Nomura Emi Yamaga Junichi Tsuchiya Tokuko Hosoya Goshi Oda Tsuyoshi Nakagawa Iichiroh Onishi Ukihide Tateishi |
| author_facet | Mio Mori Tomoyuki Fujioka Kazunori Kubota Leona Katsuta Yuka Yashima Kyoko Nomura Emi Yamaga Junichi Tsuchiya Tokuko Hosoya Goshi Oda Tsuyoshi Nakagawa Iichiroh Onishi Ukihide Tateishi |
| author_sort | Mio Mori |
| collection | DOAJ |
| description | This retrospective study examined the relationship between the standardized uptake value max (SUVmax) of fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (<sup>18</sup>F-FDG PET/CT) and the prognostic stage of breast cancer. We examined 358 breast cancers in 334 patients who underwent <sup>18</sup>F-FDG PET/CT for initial staging between January 2016 and December 2019. We extracted data including SUVmax of <sup>18</sup>F-FDG PET and pathological biomarkers, including estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2), and nuclear grade. Anatomical and prognostic stages were determined per the American Joint Committee on Cancer (eighth edition). We examined whether there were statistical differences in SUVmax between each prognostic stage. The mean SUVmax values for clinical prognostic stages were as follow: stage 0, 2.2 ± 1.4; stage IA, 2.6 ± 2.1; stage IB, 4.2 ± 3.5; stage IIA, 5.2 ± 2.8; stage IIB, 7.7 ± 6.7; and stage III + IV, 7.0 ± 4.5. The SUVmax values for pathological prognostic stages were as follows: stage 0, 2.2 ± 1.4; stage IA, 2.8 ± 2.2; stage IB, 5.4 ± 3.6; stage IIA, 6.3 ± 3.1; stage IIB, 9.2 ± 7.5, and stage III + IV, 6.2 ± 5.2. There were significant differences in mean SUVmax between clinical prognostic stage 0 and ≥II (<i>p</i> < 0.001) and I and ≥II (<i>p</i> < 0.001). There were also significant differences in mean SUVmax between pathological prognostic stage 0 and ≥II (<i>p</i> < 0.001) and I and ≥II (<i>p</i> < 0.001). In conclusion, mean SUVmax increased with all stages up to prognostic stage IIB, and there were significant differences between several stages. The SUVmax of <sup>18</sup>F-FDG PET/CT may contribute to prognostic stage stratification, particularly in early cases of breast cancers. |
| first_indexed | 2024-03-10T09:35:22Z |
| format | Article |
| id | doaj.art-75e6aad9f9294b7c8661e88b84fb00fa |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T09:35:22Z |
| publishDate | 2021-07-01 |
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| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-75e6aad9f9294b7c8661e88b84fb00fa2023-11-22T04:07:49ZengMDPI AGJournal of Clinical Medicine2077-03832021-07-011014317310.3390/jcm10143173Relationship between Prognostic Stage in Breast Cancer and Fluorine-18 Fluorodeoxyglucose Positron Emission Tomography/Computed TomographyMio Mori0Tomoyuki Fujioka1Kazunori Kubota2Leona Katsuta3Yuka Yashima4Kyoko Nomura5Emi Yamaga6Junichi Tsuchiya7Tokuko Hosoya8Goshi Oda9Tsuyoshi Nakagawa10Iichiroh Onishi11Ukihide Tateishi12Department of Diagnostic Radiology, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, JapanDepartment of Diagnostic Radiology, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, JapanDepartment of Radiology, Dokkyo Medical University Saitama Medical Center, 2-1-50 Minamikoshigaya, Koshigaya, Saitama 343-8555, JapanDepartment of Diagnostic Radiology, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, JapanDepartment of Diagnostic Radiology, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, JapanDepartment of Diagnostic Radiology, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, JapanDepartment of Diagnostic Radiology, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, JapanDepartment of Diagnostic Radiology, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, JapanDepartment of Surgery, Breast Surgery, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, JapanDepartment of Surgery, Breast Surgery, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, JapanDepartment of Surgery, Breast Surgery, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, JapanDepartment of Comprehensive Pathology, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, JapanDepartment of Diagnostic Radiology, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, JapanThis retrospective study examined the relationship between the standardized uptake value max (SUVmax) of fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (<sup>18</sup>F-FDG PET/CT) and the prognostic stage of breast cancer. We examined 358 breast cancers in 334 patients who underwent <sup>18</sup>F-FDG PET/CT for initial staging between January 2016 and December 2019. We extracted data including SUVmax of <sup>18</sup>F-FDG PET and pathological biomarkers, including estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2), and nuclear grade. Anatomical and prognostic stages were determined per the American Joint Committee on Cancer (eighth edition). We examined whether there were statistical differences in SUVmax between each prognostic stage. The mean SUVmax values for clinical prognostic stages were as follow: stage 0, 2.2 ± 1.4; stage IA, 2.6 ± 2.1; stage IB, 4.2 ± 3.5; stage IIA, 5.2 ± 2.8; stage IIB, 7.7 ± 6.7; and stage III + IV, 7.0 ± 4.5. The SUVmax values for pathological prognostic stages were as follows: stage 0, 2.2 ± 1.4; stage IA, 2.8 ± 2.2; stage IB, 5.4 ± 3.6; stage IIA, 6.3 ± 3.1; stage IIB, 9.2 ± 7.5, and stage III + IV, 6.2 ± 5.2. There were significant differences in mean SUVmax between clinical prognostic stage 0 and ≥II (<i>p</i> < 0.001) and I and ≥II (<i>p</i> < 0.001). There were also significant differences in mean SUVmax between pathological prognostic stage 0 and ≥II (<i>p</i> < 0.001) and I and ≥II (<i>p</i> < 0.001). In conclusion, mean SUVmax increased with all stages up to prognostic stage IIB, and there were significant differences between several stages. The SUVmax of <sup>18</sup>F-FDG PET/CT may contribute to prognostic stage stratification, particularly in early cases of breast cancers.https://www.mdpi.com/2077-0383/10/14/3173breast cancerpositron emission tomographystandard uptake valueprognostic stageAmerican Joint Committee on Cancer |
| spellingShingle | Mio Mori Tomoyuki Fujioka Kazunori Kubota Leona Katsuta Yuka Yashima Kyoko Nomura Emi Yamaga Junichi Tsuchiya Tokuko Hosoya Goshi Oda Tsuyoshi Nakagawa Iichiroh Onishi Ukihide Tateishi Relationship between Prognostic Stage in Breast Cancer and Fluorine-18 Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Journal of Clinical Medicine breast cancer positron emission tomography standard uptake value prognostic stage American Joint Committee on Cancer |
| title | Relationship between Prognostic Stage in Breast Cancer and Fluorine-18 Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography |
| title_full | Relationship between Prognostic Stage in Breast Cancer and Fluorine-18 Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography |
| title_fullStr | Relationship between Prognostic Stage in Breast Cancer and Fluorine-18 Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography |
| title_full_unstemmed | Relationship between Prognostic Stage in Breast Cancer and Fluorine-18 Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography |
| title_short | Relationship between Prognostic Stage in Breast Cancer and Fluorine-18 Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography |
| title_sort | relationship between prognostic stage in breast cancer and fluorine 18 fluorodeoxyglucose positron emission tomography computed tomography |
| topic | breast cancer positron emission tomography standard uptake value prognostic stage American Joint Committee on Cancer |
| url | https://www.mdpi.com/2077-0383/10/14/3173 |
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