Resistance of anti-tuberculosis drugs among pulmonary tuberculosis patients in Yemen
Background: Tuberculosis (TB) is still a major global public health problem worldwide. The global prevalence of Mycobacterium (M tuberculosis) infection has been estimated in 32% of the world population with more than 8 million new cases diagnosed each year. Materials and Methods: A total of 192...
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| Format: | Article |
| Language: | English |
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College of Medicine University of Baghdad
2013-07-01
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| Series: | مجلة كلية الطب |
| Subjects: | |
| Online Access: | http://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/625 |
| _version_ | 1797369595999289344 |
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| author | Anwar K. Al-Madhagi Khaled A. Al-Moyed Ahmed M. Al-Haddad |
| author_facet | Anwar K. Al-Madhagi Khaled A. Al-Moyed Ahmed M. Al-Haddad |
| author_sort | Anwar K. Al-Madhagi |
| collection | DOAJ |
| description | Background: Tuberculosis (TB) is still a major global public health problem worldwide. The global prevalence of Mycobacterium (M tuberculosis) infection has been estimated in 32% of the world population with more than 8 million new cases diagnosed each year.
Materials and Methods: A total of 192 M tuberculosis complex isolates were collected from patients with positive sputum smear who had been treated previously with the four main anti- tuberculosis drugs for more than two months. The isolates were identified by their colonial morphology, pigmentation, shapes on Ziehl-Neelsen smears, growth on Löwenstein-Jenson medium and biochemical tests as niacin and nitrate tests. A proportional method was used for the in vitro drug susceptibility testing.Objective: To estimate drug resistance among previously treated tuberculosis patients, focusing on multi-drug resistant strains at two time intervals (2002 and 2009) in Yemen.
Results: Of the 192 M tuberculosis complex tested isolates, 55 (28.7%) were resistant to one or more drug; 20 (10.4%) were resistant to one drug, 13 (6.8%) to two drugs, 13 (6.8%) to three drugs and 9 (4.7%) to four drugs. Regarding the resistance to an individual drug, out of 192 tested isolates, 36 (18.7%) were resistant to rifampicin, 34 (17.7%) to isoniazid, 33 (17.2%) to ethambutol and 18 (9.4%) to streptomycin and these results were without a statistical significance. The incidence of multidrug resistance against rifampicin and isoniazid with or without other drugs was 13.5% among the tested M tuberculosis complex strains and this result was also without a statistical significance.
Conclusion: The results of this study revealed nearly similar drug resistance patterns for the tested isolates in comparison with previous findings of 2002 and the emergence of more multi-drug resistance M tuberculosis complex strains after a time interval in Yemen. |
| first_indexed | 2024-03-08T17:50:08Z |
| format | Article |
| id | doaj.art-75e6d52d32934a8d8531cf6591ccaa1c |
| institution | Directory Open Access Journal |
| issn | 0041-9419 2410-8057 |
| language | English |
| last_indexed | 2024-03-08T17:50:08Z |
| publishDate | 2013-07-01 |
| publisher | College of Medicine University of Baghdad |
| record_format | Article |
| series | مجلة كلية الطب |
| spelling | doaj.art-75e6d52d32934a8d8531cf6591ccaa1c2024-01-02T09:09:00ZengCollege of Medicine University of Baghdadمجلة كلية الطب0041-94192410-80572013-07-0155310.32007/jfacmedbagdad.v3250-253%Resistance of anti-tuberculosis drugs among pulmonary tuberculosis patients in YemenAnwar K. Al-Madhagi0Khaled A. Al-Moyed1Ahmed M. Al-Haddad2Dept. of Medical Microbiology, Faculty of Medicine and Health Sciences, Sana’a University, Sana’a, Yemen.Dept. of Medical Microbiology, Faculty of Medicine and Health Sciences, Sana’a University, Sana’a, Yemen.Dept. of Basic Medical Sciences, College of Medicine and Health Sciences, Hadhramout University of Science and Technology, Al-Mukalla YemenBackground: Tuberculosis (TB) is still a major global public health problem worldwide. The global prevalence of Mycobacterium (M tuberculosis) infection has been estimated in 32% of the world population with more than 8 million new cases diagnosed each year. Materials and Methods: A total of 192 M tuberculosis complex isolates were collected from patients with positive sputum smear who had been treated previously with the four main anti- tuberculosis drugs for more than two months. The isolates were identified by their colonial morphology, pigmentation, shapes on Ziehl-Neelsen smears, growth on Löwenstein-Jenson medium and biochemical tests as niacin and nitrate tests. A proportional method was used for the in vitro drug susceptibility testing.Objective: To estimate drug resistance among previously treated tuberculosis patients, focusing on multi-drug resistant strains at two time intervals (2002 and 2009) in Yemen. Results: Of the 192 M tuberculosis complex tested isolates, 55 (28.7%) were resistant to one or more drug; 20 (10.4%) were resistant to one drug, 13 (6.8%) to two drugs, 13 (6.8%) to three drugs and 9 (4.7%) to four drugs. Regarding the resistance to an individual drug, out of 192 tested isolates, 36 (18.7%) were resistant to rifampicin, 34 (17.7%) to isoniazid, 33 (17.2%) to ethambutol and 18 (9.4%) to streptomycin and these results were without a statistical significance. The incidence of multidrug resistance against rifampicin and isoniazid with or without other drugs was 13.5% among the tested M tuberculosis complex strains and this result was also without a statistical significance. Conclusion: The results of this study revealed nearly similar drug resistance patterns for the tested isolates in comparison with previous findings of 2002 and the emergence of more multi-drug resistance M tuberculosis complex strains after a time interval in Yemen.http://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/625Tuberculosis, resistance, anti-tuberculosis drugs, MDR, Yemen. |
| spellingShingle | Anwar K. Al-Madhagi Khaled A. Al-Moyed Ahmed M. Al-Haddad Resistance of anti-tuberculosis drugs among pulmonary tuberculosis patients in Yemen مجلة كلية الطب Tuberculosis, resistance, anti-tuberculosis drugs, MDR, Yemen. |
| title | Resistance of anti-tuberculosis drugs among pulmonary tuberculosis patients in Yemen |
| title_full | Resistance of anti-tuberculosis drugs among pulmonary tuberculosis patients in Yemen |
| title_fullStr | Resistance of anti-tuberculosis drugs among pulmonary tuberculosis patients in Yemen |
| title_full_unstemmed | Resistance of anti-tuberculosis drugs among pulmonary tuberculosis patients in Yemen |
| title_short | Resistance of anti-tuberculosis drugs among pulmonary tuberculosis patients in Yemen |
| title_sort | resistance of anti tuberculosis drugs among pulmonary tuberculosis patients in yemen |
| topic | Tuberculosis, resistance, anti-tuberculosis drugs, MDR, Yemen. |
| url | http://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/625 |
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