Self-protection of individual CD4+ T cells against R5 HIV-1 infection by the synthesis of anti-viral CCR5 ligands.

Self-protection of individual CD4+ T cells against R5 HIV-1 infection by the synthesis of anti-viral CCR5 ligands.

It is well established that paracrine secretion of anti-viral CCR5 ligands by CD8+ and CD4+ T cells can block the infection of activated CD4+ T cells by R5 and dual-tropic isolates of HIV-1. By contrast, because CD4+ T cells can be infected by HIV-1 and at least some subsets secrete anti-viral CCR5...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron:	Yongjun Guan, Sayed Abdelwahab, Roberta Kamin-Lewis, Anthony L DeVico, George K Lewis
Fformat:	Erthygl
Iaith:	English
Cyhoeddwyd:	Public Library of Science (PLoS) 2008-01-01
Cyfres:	PLoS ONE
Mynediad Ar-lein:	http://europepmc.org/articles/PMC2567041?pdf=render

Eitemau Tebyg

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gan: Gero Hütter, et al.
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CD4-Induced epitopes in HIV infection
gan: Hudacik Lauren, et al.
Cyhoeddwyd: (2006-12-01)

Gene editing CCR5 in HIV subjects CD4 T cells
gan: D. Ando
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People with HIV have higher percentages of circulating CCR5+ CD8+ T cells and lower percentages of CCR5+ regulatory T cells
gan: Louise E. van Eekeren, et al.
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Stoichiometric Analyses of Soluble CD4 to Native-like HIV-1 Envelope by Single-Molecule Fluorescence Spectroscopy
gan: Parul Agrawal, et al.
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CCR5 promoter activity correlates with HIV disease progression by regulating CCR5 cell surface expression and CD4 T cell apoptosis
gan: Anjali Joshi, et al.
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Accelerated CD4(+) T cell turnover in HIV infection preferentially drives proliferation of CCR5(+) cells regardless of HIV viral co-receptor tropism
gan: Zhang, Y, et al.
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HIV-infected individuals with the CCR5Δ32/CCR5 genotype have lower HIV RNA levels and higher CD4 cell counts in the early years of the infection than do patients with the wild type
gan: Katzenstein, T, et al.
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Divergent Expression of CXCR5 and CCR5 on CD4+ T Cells and the Paradoxical Accumulation of T Follicular Helper Cells during HIV Infection
gan: John Zaunders, et al.
Cyhoeddwyd: (2017-05-01)

Conformational Masking and Receptor-Dependent Unmasking of Highly Conserved Env Epitopes Recognized by Non-Neutralizing Antibodies That Mediate Potent ADCC against HIV-1
gan: George K. Lewis, et al.
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CCR5 Receptor Occupancy Analysis Reveals Increased Peripheral Blood CCR5+CD4+ T Cells Following Treatment With the Anti-CCR5 Antibody Leronlimab
gan: Xiao L. Chang, et al.
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CCR5Delta32 genotypes in a German HIV-1 seroconverter cohort and report of HIV-1 infection in a CCR5Delta32 homozygous individual.
gan: Djin-Ye Oh, et al.
Cyhoeddwyd: (2008-01-01)

A ligand for CD5 is CD5.
gan: Brown, M, et al.
Cyhoeddwyd: (2010)

CCR5 genotype and plasma ß-chemokine concentration of Brazilian HIV-infected individuals
gan: Mikawa A.Y., et al.
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CCR5 polymorphisms and its relationship with HIV susceptibility, viral load and CD4 count in early antiretroviral therapy among HIV patients in Selangor and Terengganu
gan: Mohamad Isa, Irma Izani, et al.
Cyhoeddwyd: (2023)

B cells mediate R5-Tropic HIV infection of CCR5neg naive CD4 T cells
gan: A. Gerberick, et al.
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Modulation of CCR5 expression and R5 HIV-1 infection in primary macrophages exposed to sera from HESN, LTNP, and chronically HIV-1 infected people with or without natural antibodies to CCR5
gan: Iole Farina, et al.
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Clinical use of CCR5 inhibitors in HIV and beyond
gan: Gilliam Bruce, et al.
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The role of CCR5 in HIV-associated neurocognitive disorders
gan: Cecile Riviere-Cazaux, et al.
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In vitro pharmacoregulation of CC chemokine ligand 5 and its receptor CCR5 in diffuse lung diseases
gan: Veronika Sekerova, et al.
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IFNα induces CCR5 in CD4+ T cells of HIV patients causing pathogenic elevation
gan: Hélène Le Buanec, et al.
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Identification of HIV-1 Envelope Mutations that Enhance Entry Using Macaque CD4 and CCR5
gan: Jeremy I. Roop, et al.
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Two HIV-1 variants resistant to small molecule CCR5 inhibitors differ in how they use CCR5 for entry.
gan: Reem Berro, et al.
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gan: Alireza Andalib, et al.
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gan: Helen L. Wu, et al.
Cyhoeddwyd: (2022-12-01)

Accelerated immunodeficiency by anti-CCR5 treatment in HIV infection.
gan: Ariel D Weinberger, et al.
Cyhoeddwyd: (2009-08-01)

CCR5 as a Natural and Modulated Target for Inhibition of HIV
gan: Bryan P. Burke, et al.
Cyhoeddwyd: (2013-12-01)

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gan: Ji-Won Lee, et al.
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Natural anti-CCR5 antibodies in HIV-infection and -exposure
gan: Lopalco Lucia
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CCR5 haplotypes and mother-to-child HIV transmission in Malawi.
gan: Bonnie R Pedersen, et al.
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CCR5 and HIV infection, a view from Brussels
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gan: In-Ho Seo, et al.
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Constitutive cell surface association between CD4 and CCR5.
gan: Xiao, X, et al.
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