Self-protection of individual CD4+ T cells against R5 HIV-1 infection by the synthesis of anti-viral CCR5 ligands.

Self-protection of individual CD4+ T cells against R5 HIV-1 infection by the synthesis of anti-viral CCR5 ligands.

It is well established that paracrine secretion of anti-viral CCR5 ligands by CD8+ and CD4+ T cells can block the infection of activated CD4+ T cells by R5 and dual-tropic isolates of HIV-1. By contrast, because CD4+ T cells can be infected by HIV-1 and at least some subsets secrete anti-viral CCR5...

書目詳細資料
Main Authors:	Yongjun Guan, Sayed Abdelwahab, Roberta Kamin-Lewis, Anthony L DeVico, George K Lewis
格式:	Article
語言:	English
出版:	Public Library of Science (PLoS) 2008-01-01
叢編:	PLoS ONE
在線閱讀:	http://europepmc.org/articles/PMC2567041?pdf=render

相似書籍

The first structure of HIV-1 gp120 with CD4 and CCR5 receptors
由: Yongjun Guan
出版: (2019-01-01)

CCR5 Targeted Cell Therapy for HIV and Prevention of Viral Escape
由: Gero Hütter, et al.
出版: (2015-07-01)

CD4-Induced epitopes in HIV infection
由: Hudacik Lauren, et al.
出版: (2006-12-01)

Gene editing CCR5 in HIV subjects CD4 T cells
由: D. Ando
出版: (2015-12-01)

People with HIV have higher percentages of circulating CCR5+ CD8+ T cells and lower percentages of CCR5+ regulatory T cells
由: Louise E. van Eekeren, et al.
出版: (2022-07-01)

Stoichiometric Analyses of Soluble CD4 to Native-like HIV-1 Envelope by Single-Molecule Fluorescence Spectroscopy
由: Parul Agrawal, et al.
出版: (2019-10-01)

CCR5 promoter activity correlates with HIV disease progression by regulating CCR5 cell surface expression and CD4 T cell apoptosis
由: Anjali Joshi, et al.
出版: (2017-03-01)

Accelerated CD4(+) T cell turnover in HIV infection preferentially drives proliferation of CCR5(+) cells regardless of HIV viral co-receptor tropism
由: Zhang, Y, et al.
出版: (2010)

HIV-infected individuals with the CCR5Δ32/CCR5 genotype have lower HIV RNA levels and higher CD4 cell counts in the early years of the infection than do patients with the wild type
由: Katzenstein, T, et al.
出版: (1997)

Divergent Expression of CXCR5 and CCR5 on CD4+ T Cells and the Paradoxical Accumulation of T Follicular Helper Cells during HIV Infection
由: John Zaunders, et al.
出版: (2017-05-01)

Conformational Masking and Receptor-Dependent Unmasking of Highly Conserved Env Epitopes Recognized by Non-Neutralizing Antibodies That Mediate Potent ADCC against HIV-1
由: George K. Lewis, et al.
出版: (2015-09-01)

CCR5 Receptor Occupancy Analysis Reveals Increased Peripheral Blood CCR5+CD4+ T Cells Following Treatment With the Anti-CCR5 Antibody Leronlimab
由: Xiao L. Chang, et al.
出版: (2021-11-01)

CCR5Delta32 genotypes in a German HIV-1 seroconverter cohort and report of HIV-1 infection in a CCR5Delta32 homozygous individual.
由: Djin-Ye Oh, et al.
出版: (2008-01-01)

A ligand for CD5 is CD5.
由: Brown, M, et al.
出版: (2010)

CCR5 genotype and plasma ß-chemokine concentration of Brazilian HIV-infected individuals
由: Mikawa A.Y., et al.
出版: (2002-01-01)

CCR5 polymorphisms and its relationship with HIV susceptibility, viral load and CD4 count in early antiretroviral therapy among HIV patients in Selangor and Terengganu
由: Mohamad Isa, Irma Izani, et al.
出版: (2023)

B cells mediate R5-Tropic HIV infection of CCR5neg naive CD4 T cells
由: A. Gerberick, et al.
出版: (2019-12-01)

Modulation of CCR5 expression and R5 HIV-1 infection in primary macrophages exposed to sera from HESN, LTNP, and chronically HIV-1 infected people with or without natural antibodies to CCR5
由: Iole Farina, et al.
出版: (2024-12-01)

Clinical use of CCR5 inhibitors in HIV and beyond
由: Gilliam Bruce, et al.
出版: (2010-01-01)

The role of CCR5 in HIV-associated neurocognitive disorders
由: Cecile Riviere-Cazaux, et al.
出版: (2022-07-01)

Fat-Storing Multilocular Cells Expressing CCR5 Increase in the Thymus with Advancing Age: Potential Role for CCR5 Ligands on the Differentiation and Migration of Preadipocytes
由: Valeria de Mello Coelho, Allyson Bunbury, Leticia B. Rangel, Banabihari Giri, Ashani Weeraratna, Patrice J. Morin, Michel Bernier, Dennis D. Taub
出版: (2010-01-01)

In vitro pharmacoregulation of CC chemokine ligand 5 and its receptor CCR5 in diffuse lung diseases
由: Veronika Sekerova, et al.
出版: (2003-01-01)

IFNα induces CCR5 in CD4+ T cells of HIV patients causing pathogenic elevation
由: Hélène Le Buanec, et al.
出版: (2024-03-01)

Identification of HIV-1 Envelope Mutations that Enhance Entry Using Macaque CD4 and CCR5
由: Jeremy I. Roop, et al.
出版: (2020-02-01)

Two HIV-1 variants resistant to small molecule CCR5 inhibitors differ in how they use CCR5 for entry.
由: Reem Berro, et al.
出版: (2009-08-01)

CCR3, CCR4, CCR5, and CXCR3 expression in peripheral blood CD4+ lymphocytes in gastric cancer patients
由: Alireza Andalib, et al.
出版: (2013-01-01)

23 Knockdown of CCR5 expression in antigen-specific cytotoxic CD4 T cells
由: John Zaunders, et al.
出版: (2017-07-01)

Reduced CCR5 expression among Uganda HIV controllers
由: Brian Nyiro, et al.
出版: (2023-05-01)

OP 2.1 CCR5 in HIV Prevention and Cure
由: Helen L. Wu, et al.
出版: (2022-12-01)

Accelerated immunodeficiency by anti-CCR5 treatment in HIV infection.
由: Ariel D Weinberger, et al.
出版: (2009-08-01)

CCR5 as a Natural and Modulated Target for Inhibition of HIV
由: Bryan P. Burke, et al.
出版: (2013-12-01)

The HIV co-receptor CCR5 regulates osteoclast function
由: Ji-Won Lee, et al.
出版: (2017-12-01)

Natural anti-CCR5 antibodies in HIV-infection and -exposure
由: Lopalco Lucia
出版: (2010-01-01)

CCR5 haplotypes and mother-to-child HIV transmission in Malawi.
由: Bonnie R Pedersen, et al.
出版: (2007-09-01)

CCR5 and HIV infection, a view from Brussels
由: Marc eParmentier
出版: (2015-06-01)

IL-15 enhances CCR5-mediated migration of memory CD8+ T cells by upregulating CCR5 expression in the absence of TCR stimulation
由: In-Ho Seo, et al.
出版: (2021-07-01)

Constitutive cell surface association between CD4 and CCR5.
由: Xiao, X, et al.
出版: (1999)

CCR5-ligand decorated rilpivirine lipid-based nanoparticles for sustained antiretroviral responses
由: Milankumar Patel, et al.
出版: (2025-01-01)

Discovery of Novel CCR5 Ligands as Anticolorectal Cancer Agents by Sequential Virtual Screening
由: Mariam A. El-Zohairy, et al.
出版: (2021-04-01)

IL-15 enhances HIV-1 infection by promoting survival and proliferation of CCR5+CD4+ T cells
由: Yuhao Li, et al.
出版: (2023-04-01)