Neuroplasticity of pain processing and motor control in CAI patients: A UK Biobank study with clinical validation
BackgroundPain plays an important role in chronic ankle instability (CAI), and prolonged pain may be associated with ankle dysfunction and abnormal neuroplasticity.PurposeTo investigate the differences in resting-state functional connectivity among the pain-related brain regions and the ankle motor-...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Molecular Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnmol.2023.1096930/full |
| _version_ | 1811164246586687488 |
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| author | Yiran Wang Qianru Li Xiao'ao Xue Xiaoyun Xu Weichu Tao Sixu Liu Yunyi Li He Wang He Wang He Wang Yinghui Hua Yinghui Hua |
| author_facet | Yiran Wang Qianru Li Xiao'ao Xue Xiaoyun Xu Weichu Tao Sixu Liu Yunyi Li He Wang He Wang He Wang Yinghui Hua Yinghui Hua |
| author_sort | Yiran Wang |
| collection | DOAJ |
| description | BackgroundPain plays an important role in chronic ankle instability (CAI), and prolonged pain may be associated with ankle dysfunction and abnormal neuroplasticity.PurposeTo investigate the differences in resting-state functional connectivity among the pain-related brain regions and the ankle motor-related brain regions between healthy controls and patients with CAI, and explore the relationship between patients' motor function and pain.Study designA cross-database, cross-sectional study.MethodsThis study included a UK Biobank dataset of 28 patients with ankle pain and 109 healthy controls and a validation dataset of 15 patients with CAI and 15 healthy controls. All participants underwent resting-state functional magnetic resonance imaging scanning, and the functional connectivity (FC) among the pain-related brain regions and the ankle motor-related brain regions were calculated and compared between groups. The correlations between the potentially different functional connectivity and the clinical questionnaires were also explored in patients with CAI.ResultsThe functional connection between the cingulate motor area and insula significantly differed between groups in both the UK Biobank (p = 0.005) and clinical validation dataset (p = 0.049), which was also significantly correlated with Tegner scores (r = 0.532, p = 0.041) in patients with CAI.ConclusionA reduced functional connection between the cingulate motor area and the insula was present in patients with CAI, which was also directly correlated with reduction in the level of patient physical activity. |
| first_indexed | 2024-04-10T15:18:21Z |
| format | Article |
| id | doaj.art-75eb279ea2144a889c0bae23539d3f49 |
| institution | Directory Open Access Journal |
| issn | 1662-5099 |
| language | English |
| last_indexed | 2024-04-10T15:18:21Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Neuroscience |
| spelling | doaj.art-75eb279ea2144a889c0bae23539d3f492023-02-14T17:20:50ZengFrontiers Media S.A.Frontiers in Molecular Neuroscience1662-50992023-02-011610.3389/fnmol.2023.10969301096930Neuroplasticity of pain processing and motor control in CAI patients: A UK Biobank study with clinical validationYiran Wang0Qianru Li1Xiao'ao Xue2Xiaoyun Xu3Weichu Tao4Sixu Liu5Yunyi Li6He Wang7He Wang8He Wang9Yinghui Hua10Yinghui Hua11Department of Sports Medicine, Fudan University, Shanghai, ChinaDepartment of Sports Medicine, Fudan University, Shanghai, ChinaDepartment of Sports Medicine, Fudan University, Shanghai, ChinaSchool of Exercise and Health, Shanghai University of Sport, Shanghai, ChinaSchool of Exercise and Health, Shanghai University of Sport, Shanghai, ChinaDepartment of Biomedical Engineering, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Biomedical Engineering, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaInstitute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, ChinaHuman Phenome Institute, Fudan University, Shanghai, ChinaKey Laboratory of Computational Neuroscience and Brain-Inspired Intelligence, Ministry of Education, Fudan University, Shanghai, ChinaDepartment of Sports Medicine, Fudan University, Shanghai, ChinaYiwu Research Institute of Fudan University, Yiwu, ChinaBackgroundPain plays an important role in chronic ankle instability (CAI), and prolonged pain may be associated with ankle dysfunction and abnormal neuroplasticity.PurposeTo investigate the differences in resting-state functional connectivity among the pain-related brain regions and the ankle motor-related brain regions between healthy controls and patients with CAI, and explore the relationship between patients' motor function and pain.Study designA cross-database, cross-sectional study.MethodsThis study included a UK Biobank dataset of 28 patients with ankle pain and 109 healthy controls and a validation dataset of 15 patients with CAI and 15 healthy controls. All participants underwent resting-state functional magnetic resonance imaging scanning, and the functional connectivity (FC) among the pain-related brain regions and the ankle motor-related brain regions were calculated and compared between groups. The correlations between the potentially different functional connectivity and the clinical questionnaires were also explored in patients with CAI.ResultsThe functional connection between the cingulate motor area and insula significantly differed between groups in both the UK Biobank (p = 0.005) and clinical validation dataset (p = 0.049), which was also significantly correlated with Tegner scores (r = 0.532, p = 0.041) in patients with CAI.ConclusionA reduced functional connection between the cingulate motor area and the insula was present in patients with CAI, which was also directly correlated with reduction in the level of patient physical activity.https://www.frontiersin.org/articles/10.3389/fnmol.2023.1096930/fullankle injuriesfunctional magnetic resonance imagingfunctional connectionpaincentral nervous system |
| spellingShingle | Yiran Wang Qianru Li Xiao'ao Xue Xiaoyun Xu Weichu Tao Sixu Liu Yunyi Li He Wang He Wang He Wang Yinghui Hua Yinghui Hua Neuroplasticity of pain processing and motor control in CAI patients: A UK Biobank study with clinical validation Frontiers in Molecular Neuroscience ankle injuries functional magnetic resonance imaging functional connection pain central nervous system |
| title | Neuroplasticity of pain processing and motor control in CAI patients: A UK Biobank study with clinical validation |
| title_full | Neuroplasticity of pain processing and motor control in CAI patients: A UK Biobank study with clinical validation |
| title_fullStr | Neuroplasticity of pain processing and motor control in CAI patients: A UK Biobank study with clinical validation |
| title_full_unstemmed | Neuroplasticity of pain processing and motor control in CAI patients: A UK Biobank study with clinical validation |
| title_short | Neuroplasticity of pain processing and motor control in CAI patients: A UK Biobank study with clinical validation |
| title_sort | neuroplasticity of pain processing and motor control in cai patients a uk biobank study with clinical validation |
| topic | ankle injuries functional magnetic resonance imaging functional connection pain central nervous system |
| url | https://www.frontiersin.org/articles/10.3389/fnmol.2023.1096930/full |
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