Fatty Acid-Binding Protein 4 in Patients with and without Diabetic Retinopathy
Background Fatty acid-binding protein 4 (FABP4) has been demonstrated to be a predictor of early diabetic nephropathy. However, little is known about the relationship between FABP4 and diabetic retinopathy (DR). This study explored the value of FABP4 as a biomarker of DR in patients with type 2 diab...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Korean Diabetes Association
2022-07-01
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| Series: | Diabetes & Metabolism Journal |
| Subjects: | |
| Online Access: | http://e-dmj.org/upload/pdf/dmj-2021-0195.pdf |
| _version_ | 1818490831852535808 |
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| author | Ping Huang Xiaoqin Zhao Yi Sun Xinlei Wang Rong Ouyang Yanqiu Jiang Xiaoquan Zhang Renyue Hu Zhuqi Tang Yunjuan Gu |
| author_facet | Ping Huang Xiaoqin Zhao Yi Sun Xinlei Wang Rong Ouyang Yanqiu Jiang Xiaoquan Zhang Renyue Hu Zhuqi Tang Yunjuan Gu |
| author_sort | Ping Huang |
| collection | DOAJ |
| description | Background Fatty acid-binding protein 4 (FABP4) has been demonstrated to be a predictor of early diabetic nephropathy. However, little is known about the relationship between FABP4 and diabetic retinopathy (DR). This study explored the value of FABP4 as a biomarker of DR in patients with type 2 diabetes mellitus (T2DM). Methods A total of 238 subjects were enrolled, including 20 healthy controls and 218 T2DM patients. Serum FABP4 levels were measured using a sandwich enzyme-linked immunosorbent assay. The grade of DR was determined using fundus fluorescence angiography. Based on the international classification of DR, all T2DM patients were classified into the following three subgroups: non-DR group, non-proliferative diabetic retinopathy (NPDR) group, and proliferative diabetic retinopathy (PDR) group. Multivariate logistic regression analyses were employed to assess the correlation between FABP4 levels and DR severity. Results FABP4 correlated positively with DR severity (r=0.225, P=0.001). Receiver operating characteristic curve analysis was used to assess the diagnostic potential of FABP4 in identifying DR, with an area under the curve of 0.624 (37% sensitivity, 83.6% specificity) and an optimum cut-off value of 76.4 μg/L. Multivariate logistic regression model including FABP4 as a categorized binary variable using the cut-off value of 76.4 μg/L showed that the concentration of FABP4 above the cut-off value increased the risk of NPDR (odds ratio [OR], 3.231; 95% confidence interval [CI], 1.574 to 6.632; P=0.001) and PDR (OR, 3.689; 95% CI, 1.306 to 10.424; P=0.014). Conclusion FABP4 may be used as a serum biomarker for the diagnosis of DR. |
| first_indexed | 2024-12-10T17:22:44Z |
| format | Article |
| id | doaj.art-75ec1cae2ffa417aa937464def1759c7 |
| institution | Directory Open Access Journal |
| issn | 2233-6079 2233-6087 |
| language | English |
| last_indexed | 2024-12-10T17:22:44Z |
| publishDate | 2022-07-01 |
| publisher | Korean Diabetes Association |
| record_format | Article |
| series | Diabetes & Metabolism Journal |
| spelling | doaj.art-75ec1cae2ffa417aa937464def1759c72022-12-22T01:39:56ZengKorean Diabetes AssociationDiabetes & Metabolism Journal2233-60792233-60872022-07-0146464064910.4093/dmj.2021.01952664Fatty Acid-Binding Protein 4 in Patients with and without Diabetic RetinopathyPing Huang0Xiaoqin Zhao1Yi Sun2Xinlei Wang3Rong Ouyang4Yanqiu Jiang5Xiaoquan Zhang6Renyue Hu7Zhuqi Tang8Yunjuan Gu9 Department of Endocrinology and Metabolism, Affiliated Hospital of Nantong University, Nantong, China Department of Endocrinology and Metabolism, Affiliated Hospital of Nantong University, Nantong, China Department of Endocrinology and Metabolism, Affiliated Hospital of Nantong University, Nantong, China Department of Endocrinology and Metabolism, Affiliated Hospital of Nantong University, Nantong, China Department of Endocrinology and Metabolism, Affiliated Hospital of Nantong University, Nantong, China Department of Endocrinology and Metabolism, Affiliated Hospital of Nantong University, Nantong, China Department of Internal Medicine, Jianghai Hospital of Nantong Sutong Science and Technology Park, Nantong, China Department of Endocrinology and Metabolism, Affiliated Hospital of Nantong University, Nantong, China Department of Endocrinology and Metabolism, Affiliated Hospital of Nantong University, Nantong, China Department of Endocrinology and Metabolism, Affiliated Hospital of Nantong University, Nantong, ChinaBackground Fatty acid-binding protein 4 (FABP4) has been demonstrated to be a predictor of early diabetic nephropathy. However, little is known about the relationship between FABP4 and diabetic retinopathy (DR). This study explored the value of FABP4 as a biomarker of DR in patients with type 2 diabetes mellitus (T2DM). Methods A total of 238 subjects were enrolled, including 20 healthy controls and 218 T2DM patients. Serum FABP4 levels were measured using a sandwich enzyme-linked immunosorbent assay. The grade of DR was determined using fundus fluorescence angiography. Based on the international classification of DR, all T2DM patients were classified into the following three subgroups: non-DR group, non-proliferative diabetic retinopathy (NPDR) group, and proliferative diabetic retinopathy (PDR) group. Multivariate logistic regression analyses were employed to assess the correlation between FABP4 levels and DR severity. Results FABP4 correlated positively with DR severity (r=0.225, P=0.001). Receiver operating characteristic curve analysis was used to assess the diagnostic potential of FABP4 in identifying DR, with an area under the curve of 0.624 (37% sensitivity, 83.6% specificity) and an optimum cut-off value of 76.4 μg/L. Multivariate logistic regression model including FABP4 as a categorized binary variable using the cut-off value of 76.4 μg/L showed that the concentration of FABP4 above the cut-off value increased the risk of NPDR (odds ratio [OR], 3.231; 95% confidence interval [CI], 1.574 to 6.632; P=0.001) and PDR (OR, 3.689; 95% CI, 1.306 to 10.424; P=0.014). Conclusion FABP4 may be used as a serum biomarker for the diagnosis of DR.http://e-dmj.org/upload/pdf/dmj-2021-0195.pdfbiomarkersdiabetes mellitus, type 2diabetic retinopathydiagnosisfatty acid-binding proteins |
| spellingShingle | Ping Huang Xiaoqin Zhao Yi Sun Xinlei Wang Rong Ouyang Yanqiu Jiang Xiaoquan Zhang Renyue Hu Zhuqi Tang Yunjuan Gu Fatty Acid-Binding Protein 4 in Patients with and without Diabetic Retinopathy Diabetes & Metabolism Journal biomarkers diabetes mellitus, type 2 diabetic retinopathy diagnosis fatty acid-binding proteins |
| title | Fatty Acid-Binding Protein 4 in Patients with and without Diabetic Retinopathy |
| title_full | Fatty Acid-Binding Protein 4 in Patients with and without Diabetic Retinopathy |
| title_fullStr | Fatty Acid-Binding Protein 4 in Patients with and without Diabetic Retinopathy |
| title_full_unstemmed | Fatty Acid-Binding Protein 4 in Patients with and without Diabetic Retinopathy |
| title_short | Fatty Acid-Binding Protein 4 in Patients with and without Diabetic Retinopathy |
| title_sort | fatty acid binding protein 4 in patients with and without diabetic retinopathy |
| topic | biomarkers diabetes mellitus, type 2 diabetic retinopathy diagnosis fatty acid-binding proteins |
| url | http://e-dmj.org/upload/pdf/dmj-2021-0195.pdf |
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