Pathways shaping the mitochondrial inner membrane
Mitochondria are complex organelles with two membranes. Their architecture is determined by characteristic folds of the inner membrane, termed cristae. Recent studies in yeast and other organisms led to the identification of four major pathways that cooperate to shape cristae membranes. These includ...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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The Royal Society
2021-12-01
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| Series: | Open Biology |
| Subjects: | |
| Online Access: | https://royalsocietypublishing.org/doi/10.1098/rsob.210238 |
| _version_ | 1797837573324800000 |
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| author | Till Klecker Benedikt Westermann |
| author_facet | Till Klecker Benedikt Westermann |
| author_sort | Till Klecker |
| collection | DOAJ |
| description | Mitochondria are complex organelles with two membranes. Their architecture is determined by characteristic folds of the inner membrane, termed cristae. Recent studies in yeast and other organisms led to the identification of four major pathways that cooperate to shape cristae membranes. These include dimer formation of the mitochondrial ATP synthase, assembly of the mitochondrial contact site and cristae organizing system (MICOS), inner membrane remodelling by a dynamin-related GTPase (Mgm1/OPA1), and modulation of the mitochondrial lipid composition. In this review, we describe the function of the evolutionarily conserved machineries involved in mitochondrial cristae biogenesis with a focus on yeast and present current models to explain how their coordinated activities establish mitochondrial membrane architecture. |
| first_indexed | 2024-04-09T15:27:58Z |
| format | Article |
| id | doaj.art-75ecfe2df5b849dc9bd84ff4db1fee07 |
| institution | Directory Open Access Journal |
| issn | 2046-2441 |
| language | English |
| last_indexed | 2024-04-09T15:27:58Z |
| publishDate | 2021-12-01 |
| publisher | The Royal Society |
| record_format | Article |
| series | Open Biology |
| spelling | doaj.art-75ecfe2df5b849dc9bd84ff4db1fee072023-04-28T11:06:27ZengThe Royal SocietyOpen Biology2046-24412021-12-01111210.1098/rsob.210238Pathways shaping the mitochondrial inner membraneTill Klecker0Benedikt Westermann1Institut für Zellbiologie, Universität Bayreuth, 95440 Bayreuth, GermanyInstitut für Zellbiologie, Universität Bayreuth, 95440 Bayreuth, GermanyMitochondria are complex organelles with two membranes. Their architecture is determined by characteristic folds of the inner membrane, termed cristae. Recent studies in yeast and other organisms led to the identification of four major pathways that cooperate to shape cristae membranes. These include dimer formation of the mitochondrial ATP synthase, assembly of the mitochondrial contact site and cristae organizing system (MICOS), inner membrane remodelling by a dynamin-related GTPase (Mgm1/OPA1), and modulation of the mitochondrial lipid composition. In this review, we describe the function of the evolutionarily conserved machineries involved in mitochondrial cristae biogenesis with a focus on yeast and present current models to explain how their coordinated activities establish mitochondrial membrane architecture.https://royalsocietypublishing.org/doi/10.1098/rsob.210238ATP synthasecristaeMgm1MICOSmitochondrial lipidsSaccharomyces cerevisiae |
| spellingShingle | Till Klecker Benedikt Westermann Pathways shaping the mitochondrial inner membrane Open Biology ATP synthase cristae Mgm1 MICOS mitochondrial lipids Saccharomyces cerevisiae |
| title | Pathways shaping the mitochondrial inner membrane |
| title_full | Pathways shaping the mitochondrial inner membrane |
| title_fullStr | Pathways shaping the mitochondrial inner membrane |
| title_full_unstemmed | Pathways shaping the mitochondrial inner membrane |
| title_short | Pathways shaping the mitochondrial inner membrane |
| title_sort | pathways shaping the mitochondrial inner membrane |
| topic | ATP synthase cristae Mgm1 MICOS mitochondrial lipids Saccharomyces cerevisiae |
| url | https://royalsocietypublishing.org/doi/10.1098/rsob.210238 |
| work_keys_str_mv | AT tillklecker pathwaysshapingthemitochondrialinnermembrane AT benediktwestermann pathwaysshapingthemitochondrialinnermembrane |