Formulation and In Vitro Evaluation of Mucoadhesive Nystatin Vaginal Gel
Nystatin was prepared as vaginal gels using mucoadhesive polymers to provide mucoadhesive property which in turns increase its effectiveness; different formulas were prepared which were evaluated for the in vitro drug release and for their physical properties (swelling index, viscosity, rheological...
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| Format: | Article |
| Language: | English |
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College of Pharmacy / Mustansiriyah University
2012-12-01
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| Series: | Al-Mustansiriyah Journal of Pharmaceutical Sciences |
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| Online Access: | https://ajps.uomustansiriyah.edu.iq/index.php/AJPS/article/view/255 |
| _version_ | 1797223930686078976 |
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| author | Abeer H. Khasraghi |
| author_facet | Abeer H. Khasraghi |
| author_sort | Abeer H. Khasraghi |
| collection | DOAJ |
| description |
Nystatin was prepared as vaginal gels using mucoadhesive polymers to provide mucoadhesive property which in turns increase its effectiveness; different formulas were prepared which were evaluated for the in vitro drug release and for their physical properties (swelling index, viscosity, rheological behavior, pH, spreadability, and mucoadhesive characteristics). The influence of type and concentration of gelling agent [2.5 and 3.5 %w/w carboxymethylcellulose (CMC), 0.5 and 1% w/w carbopol 934 (CP 934), and 3 and 4% w/w xanthan gum], besides the effect of addition of different concentration (1, 3, 5, and 10%w/w) of tween 80 (TW.80) as a surfactant on nystatin release from the prepared gels were investigated. All the prepared formulas were observed to have accepted physical properties and with higher release amount after 5 hours in comparison with Nystatin® vaginal cream (Lifepharma, Italy).
It was found that CMC containing gel produced the highest nystatin release compared with other polymer types used, also as the polymer concentration increased, the amount of nystatin released decreased. Addition of 1%w/w TW. 80 increased nystatin release, also the release from CMC containing gel was appeared to increase with increasing TW. 80 concentration (from 1 to 10% w/w), It was found that the formula containing CMC in a concentration of 2.5% w/w and TW. 80 in a concentration of 5% w/w was the formula of choice due to its optimum drug release and physical properties, rheological study revealed that this formula exhibited pseudoplastic flow with shearthinnig behavior and thixotrpy. All formulas were found to follow zero order release kinetics
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| first_indexed | 2024-04-24T13:45:03Z |
| format | Article |
| id | doaj.art-75edeaa9f8f24fb5bce6a2096dcdd4dd |
| institution | Directory Open Access Journal |
| issn | 1815-0993 2959-183X |
| language | English |
| last_indexed | 2024-04-24T13:45:03Z |
| publishDate | 2012-12-01 |
| publisher | College of Pharmacy / Mustansiriyah University |
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| series | Al-Mustansiriyah Journal of Pharmaceutical Sciences |
| spelling | doaj.art-75edeaa9f8f24fb5bce6a2096dcdd4dd2024-04-04T06:58:46ZengCollege of Pharmacy / Mustansiriyah UniversityAl-Mustansiriyah Journal of Pharmaceutical Sciences1815-09932959-183X2012-12-0112210.32947/ajps.v12i2.255Formulation and In Vitro Evaluation of Mucoadhesive Nystatin Vaginal GelAbeer H. Khasraghi0Department of Pharmaceutics, College of Pharmacy, University of Baghdad, Iraq. Nystatin was prepared as vaginal gels using mucoadhesive polymers to provide mucoadhesive property which in turns increase its effectiveness; different formulas were prepared which were evaluated for the in vitro drug release and for their physical properties (swelling index, viscosity, rheological behavior, pH, spreadability, and mucoadhesive characteristics). The influence of type and concentration of gelling agent [2.5 and 3.5 %w/w carboxymethylcellulose (CMC), 0.5 and 1% w/w carbopol 934 (CP 934), and 3 and 4% w/w xanthan gum], besides the effect of addition of different concentration (1, 3, 5, and 10%w/w) of tween 80 (TW.80) as a surfactant on nystatin release from the prepared gels were investigated. All the prepared formulas were observed to have accepted physical properties and with higher release amount after 5 hours in comparison with Nystatin® vaginal cream (Lifepharma, Italy). It was found that CMC containing gel produced the highest nystatin release compared with other polymer types used, also as the polymer concentration increased, the amount of nystatin released decreased. Addition of 1%w/w TW. 80 increased nystatin release, also the release from CMC containing gel was appeared to increase with increasing TW. 80 concentration (from 1 to 10% w/w), It was found that the formula containing CMC in a concentration of 2.5% w/w and TW. 80 in a concentration of 5% w/w was the formula of choice due to its optimum drug release and physical properties, rheological study revealed that this formula exhibited pseudoplastic flow with shearthinnig behavior and thixotrpy. All formulas were found to follow zero order release kinetics https://ajps.uomustansiriyah.edu.iq/index.php/AJPS/article/view/255nystatin, mucoadhesive, vaginal gel |
| spellingShingle | Abeer H. Khasraghi Formulation and In Vitro Evaluation of Mucoadhesive Nystatin Vaginal Gel Al-Mustansiriyah Journal of Pharmaceutical Sciences nystatin, mucoadhesive, vaginal gel |
| title | Formulation and In Vitro Evaluation of Mucoadhesive Nystatin Vaginal Gel |
| title_full | Formulation and In Vitro Evaluation of Mucoadhesive Nystatin Vaginal Gel |
| title_fullStr | Formulation and In Vitro Evaluation of Mucoadhesive Nystatin Vaginal Gel |
| title_full_unstemmed | Formulation and In Vitro Evaluation of Mucoadhesive Nystatin Vaginal Gel |
| title_short | Formulation and In Vitro Evaluation of Mucoadhesive Nystatin Vaginal Gel |
| title_sort | formulation and in vitro evaluation of mucoadhesive nystatin vaginal gel |
| topic | nystatin, mucoadhesive, vaginal gel |
| url | https://ajps.uomustansiriyah.edu.iq/index.php/AJPS/article/view/255 |
| work_keys_str_mv | AT abeerhkhasraghi formulationandinvitroevaluationofmucoadhesivenystatinvaginalgel |