RBP-J is required for M2 macrophage polarization in response to chitin and mediates expression of a subset of M2 genes

RBP-J is required for M2 macrophage polarization in response to chitin and mediates expression of a subset of M2 genes

Abstract Development of alternatively activated (M2) macrophage phenotypes is a complex process that is coordinately regulated by a plethora of pathways and factors. Here, we report that RBP-J, a DNA-binding protein that integrates signals from multiple pathways including the Notch pathway, is criti...

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Bibliographic Details
Main Authors: Julia Foldi, Yingli Shang, Baohong Zhao, Lionel B. Ivashkiv, Xiaoyu Hu
Format: Article
Language:English
Published: Oxford University Press 2016-02-01
Series:Protein & Cell
Subjects:
macrophages
RBP-J
M2
arginase
chitin
Online Access:http://link.springer.com/article/10.1007/s13238-016-0248-7

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