Exploring the role of the outer subventricular zone during cortical folding through a physics-based model
The human brain has a highly complex structure both on the microscopic and on the macroscopic scales. Increasing evidence has suggested the role of mechanical forces for cortical folding – a classical hallmark of the human brain. However, the link between cellular processes at the microscale and mec...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
eLife Sciences Publications Ltd
2023-04-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/82925 |
| _version_ | 1797847910915768320 |
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| author | Mohammad Saeed Zarzor Ingmar Blumcke Silvia Budday |
| author_facet | Mohammad Saeed Zarzor Ingmar Blumcke Silvia Budday |
| author_sort | Mohammad Saeed Zarzor |
| collection | DOAJ |
| description | The human brain has a highly complex structure both on the microscopic and on the macroscopic scales. Increasing evidence has suggested the role of mechanical forces for cortical folding – a classical hallmark of the human brain. However, the link between cellular processes at the microscale and mechanical forces at the macroscale remains insufficiently understood. Recent findings suggest that an additional proliferating zone, the outer subventricular zone (OSVZ), is decisive for the particular size and complexity of the human cortex. To better understand how the OSVZ affects cortical folding, we establish a multifield computational model that couples cell proliferation in different zones and migration at the cell scale with growth and cortical folding at the organ scale by combining an advection-diffusion model with the theory of finite growth. We validate our model based on data from histologically stained sections of the human fetal brain and predict 3D pattern formation. Finally, we address open questions regarding the role of the OSVZ for the formation of cortical folds. The presented framework not only improves our understanding of human brain development, but could eventually help diagnose and treat neuronal disorders arising from disruptions in cellular development and associated malformations of cortical development. |
| first_indexed | 2024-04-09T18:18:54Z |
| format | Article |
| id | doaj.art-75ee0f421fc0485986ab712a3ffec12c |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-09T18:18:54Z |
| publishDate | 2023-04-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-75ee0f421fc0485986ab712a3ffec12c2023-04-12T15:32:07ZengeLife Sciences Publications LtdeLife2050-084X2023-04-011210.7554/eLife.82925Exploring the role of the outer subventricular zone during cortical folding through a physics-based modelMohammad Saeed Zarzor0https://orcid.org/0000-0002-3005-6115Ingmar Blumcke1Silvia Budday2https://orcid.org/0000-0002-7072-8174Friedrich-Alexander-Universität Erlangen-Nürnberg, Institute of Applied Mechanics, Erlangen, GermanyUniversity Hospitals Erlangen, Institute of Neuropathology, Erlangen, GermanyFriedrich-Alexander-Universität Erlangen-Nürnberg, Institute of Applied Mechanics, Erlangen, GermanyThe human brain has a highly complex structure both on the microscopic and on the macroscopic scales. Increasing evidence has suggested the role of mechanical forces for cortical folding – a classical hallmark of the human brain. However, the link between cellular processes at the microscale and mechanical forces at the macroscale remains insufficiently understood. Recent findings suggest that an additional proliferating zone, the outer subventricular zone (OSVZ), is decisive for the particular size and complexity of the human cortex. To better understand how the OSVZ affects cortical folding, we establish a multifield computational model that couples cell proliferation in different zones and migration at the cell scale with growth and cortical folding at the organ scale by combining an advection-diffusion model with the theory of finite growth. We validate our model based on data from histologically stained sections of the human fetal brain and predict 3D pattern formation. Finally, we address open questions regarding the role of the OSVZ for the formation of cortical folds. The presented framework not only improves our understanding of human brain development, but could eventually help diagnose and treat neuronal disorders arising from disruptions in cellular development and associated malformations of cortical development.https://elifesciences.org/articles/82925outer subventricular zonemultifield modelinghuman brain developmentouter radial glial cellsfinite element simulations |
| spellingShingle | Mohammad Saeed Zarzor Ingmar Blumcke Silvia Budday Exploring the role of the outer subventricular zone during cortical folding through a physics-based model eLife outer subventricular zone multifield modeling human brain development outer radial glial cells finite element simulations |
| title | Exploring the role of the outer subventricular zone during cortical folding through a physics-based model |
| title_full | Exploring the role of the outer subventricular zone during cortical folding through a physics-based model |
| title_fullStr | Exploring the role of the outer subventricular zone during cortical folding through a physics-based model |
| title_full_unstemmed | Exploring the role of the outer subventricular zone during cortical folding through a physics-based model |
| title_short | Exploring the role of the outer subventricular zone during cortical folding through a physics-based model |
| title_sort | exploring the role of the outer subventricular zone during cortical folding through a physics based model |
| topic | outer subventricular zone multifield modeling human brain development outer radial glial cells finite element simulations |
| url | https://elifesciences.org/articles/82925 |
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