The clinical efficacy of dabigatran etexilate for preventing stroke in atrial fibrillation patients
Christopher R Ellis, Daniel W KaiserVanderbilt Heart and Vascular Institute, Nashville, TN, USAAbstract: The use of novel oral anticoagulants (NOACs) for stroke and systemic embolism prevention in the setting of specifically non valvular atrial fibrillation has provided clinicians with a realistic t...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2013-07-01
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| Series: | Vascular Health and Risk Management |
| Online Access: | http://www.dovepress.com/the-clinical-efficacy-of-dabigatran-etexilate-for-preventing-stroke-in-a13613 |
| _version_ | 1818980843851350016 |
|---|---|
| author | Ellis CR Kaiser DW |
| author_facet | Ellis CR Kaiser DW |
| author_sort | Ellis CR |
| collection | DOAJ |
| description | Christopher R Ellis, Daniel W KaiserVanderbilt Heart and Vascular Institute, Nashville, TN, USAAbstract: The use of novel oral anticoagulants (NOACs) for stroke and systemic embolism prevention in the setting of specifically non valvular atrial fibrillation has provided clinicians with a realistic treatment alternative to the traditional dose-adjusted, warfarin-based anticoagulation that is targeted to a therapeutic international normalized ratio range of 2.0–3.0. We discuss the use of dabigatran in the setting of mechanical heart valves, atrial fibrillation or left atrial catheter ablation procedures, reversal of the drug in the setting of adverse bleeding events, and background on the molecular biology and development of this novel treatment for stroke reduction.Keywords: NOACs, systemic embolism, atrial fibrillation, stroke, dabigatran etexilate |
| first_indexed | 2024-12-20T17:21:52Z |
| format | Article |
| id | doaj.art-75ee20240c894a84b74c5e3ddc99cb07 |
| institution | Directory Open Access Journal |
| issn | 1176-6344 1178-2048 |
| language | English |
| last_indexed | 2024-12-20T17:21:52Z |
| publishDate | 2013-07-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Vascular Health and Risk Management |
| spelling | doaj.art-75ee20240c894a84b74c5e3ddc99cb072022-12-21T19:31:46ZengDove Medical PressVascular Health and Risk Management1176-63441178-20482013-07-012013default341352The clinical efficacy of dabigatran etexilate for preventing stroke in atrial fibrillation patientsEllis CRKaiser DWChristopher R Ellis, Daniel W KaiserVanderbilt Heart and Vascular Institute, Nashville, TN, USAAbstract: The use of novel oral anticoagulants (NOACs) for stroke and systemic embolism prevention in the setting of specifically non valvular atrial fibrillation has provided clinicians with a realistic treatment alternative to the traditional dose-adjusted, warfarin-based anticoagulation that is targeted to a therapeutic international normalized ratio range of 2.0–3.0. We discuss the use of dabigatran in the setting of mechanical heart valves, atrial fibrillation or left atrial catheter ablation procedures, reversal of the drug in the setting of adverse bleeding events, and background on the molecular biology and development of this novel treatment for stroke reduction.Keywords: NOACs, systemic embolism, atrial fibrillation, stroke, dabigatran etexilatehttp://www.dovepress.com/the-clinical-efficacy-of-dabigatran-etexilate-for-preventing-stroke-in-a13613 |
| spellingShingle | Ellis CR Kaiser DW The clinical efficacy of dabigatran etexilate for preventing stroke in atrial fibrillation patients Vascular Health and Risk Management |
| title | The clinical efficacy of dabigatran etexilate for preventing stroke in atrial fibrillation patients |
| title_full | The clinical efficacy of dabigatran etexilate for preventing stroke in atrial fibrillation patients |
| title_fullStr | The clinical efficacy of dabigatran etexilate for preventing stroke in atrial fibrillation patients |
| title_full_unstemmed | The clinical efficacy of dabigatran etexilate for preventing stroke in atrial fibrillation patients |
| title_short | The clinical efficacy of dabigatran etexilate for preventing stroke in atrial fibrillation patients |
| title_sort | clinical efficacy of dabigatran etexilate for preventing stroke in atrial fibrillation patients |
| url | http://www.dovepress.com/the-clinical-efficacy-of-dabigatran-etexilate-for-preventing-stroke-in-a13613 |
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