Growth hormone deficiency in childhood brain tumors and acute lymphoblastic leukemia survivors
Thanks to modern treatment protocols, childhood cancer survivors (CCS) are a very fast-growing population nowadays. Cancer therapy inevitably leads to different late adverse effects, where endocrine disorders are highly prevalent, including growth hormone deficiency (GHD) which is the most common en...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Endocrinology Research Centre
2022-02-01
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| Series: | Ожирение и метаболизм |
| Subjects: | |
| Online Access: | https://www.omet-endojournals.ru/jour/article/view/12786 |
| _version_ | 1797204606655135744 |
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| author | M. G. Pavlova T. Y. Tselovalnikova A. E. Yudina O. O. Golounina A. V. Zilov N. A. Mazerkina O. G. Zheludkova V. V. Fadeev |
| author_facet | M. G. Pavlova T. Y. Tselovalnikova A. E. Yudina O. O. Golounina A. V. Zilov N. A. Mazerkina O. G. Zheludkova V. V. Fadeev |
| author_sort | M. G. Pavlova |
| collection | DOAJ |
| description | Thanks to modern treatment protocols, childhood cancer survivors (CCS) are a very fast-growing population nowadays. Cancer therapy inevitably leads to different late adverse effects, where endocrine disorders are highly prevalent, including growth hormone deficiency (GHD) which is the most common endocrine outcome after cancer treatment in childhood and contributes to impaired growth. Short stature is a big issue, which leads to problems in psychological and social adaptation of patients and reduces their quality of life. Impact of GH treatment on various physiological processes and global outcome of CCS is of great interest. Several studies have demonstrated an influence of GH and IGF-1 on the development/tumour growth, cell proliferation. In this regard, the issue of increasing the risk of cancer recurrence and/or the development of secondary neoplasms in CCS, causes a lot of controversy and is the subject of continuous evaluation. In this review, we went through the available data on the prevalence and pathogenesis of GHD following chemo- and radiotherapy, in particular after treatment of brain tumors and acute lymphoblastic leukaemia in childhood. In addition, here we discuss the existing problems in the diagnosis of GHD, the safety of GH replacement therapy, as well as the treatment algorithm of the GHD in adults. |
| first_indexed | 2024-03-08T09:13:15Z |
| format | Article |
| id | doaj.art-75ee8dabac444aa69752c10862ee96fe |
| institution | Directory Open Access Journal |
| issn | 2071-8713 2306-5524 |
| language | English |
| last_indexed | 2024-04-24T08:37:54Z |
| publishDate | 2022-02-01 |
| publisher | Endocrinology Research Centre |
| record_format | Article |
| series | Ожирение и метаболизм |
| spelling | doaj.art-75ee8dabac444aa69752c10862ee96fe2024-04-16T16:16:13ZengEndocrinology Research CentreОжирение и метаболизм2071-87132306-55242022-02-0118448449510.14341/omet1278610906Growth hormone deficiency in childhood brain tumors and acute lymphoblastic leukemia survivorsM. G. Pavlova0T. Y. Tselovalnikova1A. E. Yudina2O. O. Golounina3A. V. Zilov4N. A. Mazerkina5O. G. Zheludkova6V. V. Fadeev7I.M. Sechenov First Moscow State Medical University (Sechenov University)I.M. Sechenov First Moscow State Medical University (Sechenov University)I.M. Sechenov First Moscow State Medical University (Sechenov University)I.M. Sechenov First Moscow State Medical University (Sechenov University)I.M. Sechenov First Moscow State Medical University (Sechenov University)N.N. Burdenko national medical research center of neurosurgeryVoino-Yasenetsky Krasnoyarsk State Medical UniversityI.M. Sechenov First Moscow State Medical University (Sechenov University)Thanks to modern treatment protocols, childhood cancer survivors (CCS) are a very fast-growing population nowadays. Cancer therapy inevitably leads to different late adverse effects, where endocrine disorders are highly prevalent, including growth hormone deficiency (GHD) which is the most common endocrine outcome after cancer treatment in childhood and contributes to impaired growth. Short stature is a big issue, which leads to problems in psychological and social adaptation of patients and reduces their quality of life. Impact of GH treatment on various physiological processes and global outcome of CCS is of great interest. Several studies have demonstrated an influence of GH and IGF-1 on the development/tumour growth, cell proliferation. In this regard, the issue of increasing the risk of cancer recurrence and/or the development of secondary neoplasms in CCS, causes a lot of controversy and is the subject of continuous evaluation. In this review, we went through the available data on the prevalence and pathogenesis of GHD following chemo- and radiotherapy, in particular after treatment of brain tumors and acute lymphoblastic leukaemia in childhood. In addition, here we discuss the existing problems in the diagnosis of GHD, the safety of GH replacement therapy, as well as the treatment algorithm of the GHD in adults.https://www.omet-endojournals.ru/jour/article/view/12786growth hormonegrowth hormone deficiencycancerradiation therapygrowth hormone replacement therapymalignant neoplasmsbrain tumorsacute lymphoblastic leukaemia |
| spellingShingle | M. G. Pavlova T. Y. Tselovalnikova A. E. Yudina O. O. Golounina A. V. Zilov N. A. Mazerkina O. G. Zheludkova V. V. Fadeev Growth hormone deficiency in childhood brain tumors and acute lymphoblastic leukemia survivors Ожирение и метаболизм growth hormone growth hormone deficiency cancer radiation therapy growth hormone replacement therapy malignant neoplasms brain tumors acute lymphoblastic leukaemia |
| title | Growth hormone deficiency in childhood brain tumors and acute lymphoblastic leukemia survivors |
| title_full | Growth hormone deficiency in childhood brain tumors and acute lymphoblastic leukemia survivors |
| title_fullStr | Growth hormone deficiency in childhood brain tumors and acute lymphoblastic leukemia survivors |
| title_full_unstemmed | Growth hormone deficiency in childhood brain tumors and acute lymphoblastic leukemia survivors |
| title_short | Growth hormone deficiency in childhood brain tumors and acute lymphoblastic leukemia survivors |
| title_sort | growth hormone deficiency in childhood brain tumors and acute lymphoblastic leukemia survivors |
| topic | growth hormone growth hormone deficiency cancer radiation therapy growth hormone replacement therapy malignant neoplasms brain tumors acute lymphoblastic leukaemia |
| url | https://www.omet-endojournals.ru/jour/article/view/12786 |
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