A novel antibody humanization method based on epitopes scanning and molecular dynamics simulation.

A novel antibody humanization method based on epitopes scanning and molecular dynamics simulation.

1-17-2 is a rat anti-human DEC-205 monoclonal antibody that induces internalization and delivers antigen to dendritic cells (DCs). The potentially clinical application of this antibody is limited by its murine origin. Traditional humanization method such as complementarity determining regions (CDRs)...

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Bibliographic Details
Main Authors:	Ding Zhang, Cai-Feng Chen, Bin-Bin Zhao, Lu-Lu Gong, Wen-Jing Jin, Jing-Jun Liu, Jing-Fei Wang, Tian-Tian Wang, Xiao-Hui Yuan, You-Wen He
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2013-01-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC3836750?pdf=render

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