Lifetime stress cumulatively programs brain transcriptome and impedes stroke recovery: benefit of sensory stimulation.
Prenatal stress (PS) represents a critical variable affecting lifetime health trajectories, metabolic and vascular functions. Beneficial experiences may attenuate the effects of PS and its programming of health outcomes in later life. Here we investigated in a rat model (1) if PS modulates recovery...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24651125/?tool=EBI |
| _version_ | 1818833842437357568 |
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| author | Fabíola C R Zucchi Youli Yao Yaroslav Ilnytskyy Jerrah C Robbins Nasrin Soltanpour Igor Kovalchuk Olga Kovalchuk Gerlinde A S Metz |
| author_facet | Fabíola C R Zucchi Youli Yao Yaroslav Ilnytskyy Jerrah C Robbins Nasrin Soltanpour Igor Kovalchuk Olga Kovalchuk Gerlinde A S Metz |
| author_sort | Fabíola C R Zucchi |
| collection | DOAJ |
| description | Prenatal stress (PS) represents a critical variable affecting lifetime health trajectories, metabolic and vascular functions. Beneficial experiences may attenuate the effects of PS and its programming of health outcomes in later life. Here we investigated in a rat model (1) if PS modulates recovery following cortical ischemia in adulthood; (2) if a second hit by adult stress (AS) exaggerates stress responses and ischemic damage; and (3) if tactile stimulation (TS) attenuates the cumulative effects of PS and AS. Prenatally stressed and non-stressed adult male rats underwent focal ischemic motor cortex lesion and were tested in skilled reaching and skilled walking tasks. Two groups of rats experienced recurrent restraint stress in adulthood and one of these groups also underwent daily TS therapy. Animals that experienced both PS and AS displayed the most severe motor disabilities after lesion. By contrast, TS promoted recovery from ischemic lesion and reduced hypothalamic-pituitary-adrenal axis activity. The data also showed that cumulative effects of adverse and beneficial lifespan experiences interact with disease outcomes and brain plasticity through the modulation of gene expression. Microarray analysis of the lesion motor cortex revealed that cumulative PS and AS interact with genes related to growth factors and transcription factors, which were not affected by PS or lesion alone. TS in PS+AS animals reverted these changes, suggesting a critical role for these factors in activity-dependent motor cortical reorganization after ischemic lesion. These findings suggest that beneficial experience later in life can moderate adverse consequences of early programming to improve cerebrovascular health. |
| first_indexed | 2024-12-19T02:25:21Z |
| format | Article |
| id | doaj.art-75f0697b036e41aab4186b9c57223888 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-19T02:25:21Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-75f0697b036e41aab4186b9c572238882022-12-21T20:39:57ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0193e9213010.1371/journal.pone.0092130Lifetime stress cumulatively programs brain transcriptome and impedes stroke recovery: benefit of sensory stimulation.Fabíola C R ZucchiYouli YaoYaroslav IlnytskyyJerrah C RobbinsNasrin SoltanpourIgor KovalchukOlga KovalchukGerlinde A S MetzPrenatal stress (PS) represents a critical variable affecting lifetime health trajectories, metabolic and vascular functions. Beneficial experiences may attenuate the effects of PS and its programming of health outcomes in later life. Here we investigated in a rat model (1) if PS modulates recovery following cortical ischemia in adulthood; (2) if a second hit by adult stress (AS) exaggerates stress responses and ischemic damage; and (3) if tactile stimulation (TS) attenuates the cumulative effects of PS and AS. Prenatally stressed and non-stressed adult male rats underwent focal ischemic motor cortex lesion and were tested in skilled reaching and skilled walking tasks. Two groups of rats experienced recurrent restraint stress in adulthood and one of these groups also underwent daily TS therapy. Animals that experienced both PS and AS displayed the most severe motor disabilities after lesion. By contrast, TS promoted recovery from ischemic lesion and reduced hypothalamic-pituitary-adrenal axis activity. The data also showed that cumulative effects of adverse and beneficial lifespan experiences interact with disease outcomes and brain plasticity through the modulation of gene expression. Microarray analysis of the lesion motor cortex revealed that cumulative PS and AS interact with genes related to growth factors and transcription factors, which were not affected by PS or lesion alone. TS in PS+AS animals reverted these changes, suggesting a critical role for these factors in activity-dependent motor cortical reorganization after ischemic lesion. These findings suggest that beneficial experience later in life can moderate adverse consequences of early programming to improve cerebrovascular health.https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24651125/?tool=EBI |
| spellingShingle | Fabíola C R Zucchi Youli Yao Yaroslav Ilnytskyy Jerrah C Robbins Nasrin Soltanpour Igor Kovalchuk Olga Kovalchuk Gerlinde A S Metz Lifetime stress cumulatively programs brain transcriptome and impedes stroke recovery: benefit of sensory stimulation. PLoS ONE |
| title | Lifetime stress cumulatively programs brain transcriptome and impedes stroke recovery: benefit of sensory stimulation. |
| title_full | Lifetime stress cumulatively programs brain transcriptome and impedes stroke recovery: benefit of sensory stimulation. |
| title_fullStr | Lifetime stress cumulatively programs brain transcriptome and impedes stroke recovery: benefit of sensory stimulation. |
| title_full_unstemmed | Lifetime stress cumulatively programs brain transcriptome and impedes stroke recovery: benefit of sensory stimulation. |
| title_short | Lifetime stress cumulatively programs brain transcriptome and impedes stroke recovery: benefit of sensory stimulation. |
| title_sort | lifetime stress cumulatively programs brain transcriptome and impedes stroke recovery benefit of sensory stimulation |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24651125/?tool=EBI |
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