Electrochemical and biological performance of hierarchical platinum-iridium electrodes structured by a femtosecond laser
Abstract Neural electrode interfaces are essential to the stimulation safety and recording quality of various bioelectronic therapies. The recently proposed hierarchical platinum-iridium (Pt-Ir) electrodes produced by femtosecond lasers have exhibited superior electrochemical performance in vitro, b...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2022-09-01
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| Series: | Microsystems & Nanoengineering |
| Online Access: | https://doi.org/10.1038/s41378-022-00433-8 |
| _version_ | 1828352014921236480 |
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| author | Linze Li Changqing Jiang Wanru Duan Zhiyan Wang Feng Zhang Changgeng He Tiangang Long Luming Li |
| author_facet | Linze Li Changqing Jiang Wanru Duan Zhiyan Wang Feng Zhang Changgeng He Tiangang Long Luming Li |
| author_sort | Linze Li |
| collection | DOAJ |
| description | Abstract Neural electrode interfaces are essential to the stimulation safety and recording quality of various bioelectronic therapies. The recently proposed hierarchical platinum-iridium (Pt-Ir) electrodes produced by femtosecond lasers have exhibited superior electrochemical performance in vitro, but their in vivo performance is still unclear. In this study, we explored the electrochemical performance, biological response, and tissue adhesion of hierarchical Pt-Ir electrodes by implantation in adult rat brains for 1, 8, and 16 weeks. Regular smooth Pt-Ir electrodes were used as a control. The results showed that the electrochemical performance of both electrodes decreased and leveled off during implantation. However, after 16 weeks, the charge storage capacity of hierarchical electrodes stabilized at ~16.8 mC/cm2, which was 15 times that of the smooth control electrodes (1.1 mC/cm2). Moreover, the highly structured electrodes had lower impedance amplitude and cutoff frequency values. The similar histological response to smooth electrodes indicated good biocompatibility of the hierarchically structured Pt-Ir electrodes. Given their superior in vivo performance, the femtosecond laser-treated Pt-Ir electrode showed great potential for neuromodulation applications. |
| first_indexed | 2024-04-14T01:47:44Z |
| format | Article |
| id | doaj.art-75f66ae8455a45cea140638122aad264 |
| institution | Directory Open Access Journal |
| issn | 2055-7434 |
| language | English |
| last_indexed | 2024-04-14T01:47:44Z |
| publishDate | 2022-09-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Microsystems & Nanoengineering |
| spelling | doaj.art-75f66ae8455a45cea140638122aad2642022-12-22T02:19:27ZengNature Publishing GroupMicrosystems & Nanoengineering2055-74342022-09-018111010.1038/s41378-022-00433-8Electrochemical and biological performance of hierarchical platinum-iridium electrodes structured by a femtosecond laserLinze Li0Changqing Jiang1Wanru Duan2Zhiyan Wang3Feng Zhang4Changgeng He5Tiangang Long6Luming Li7National Engineering Research Center of Neuromodulation, School of Aerospace Engineering, Tsinghua UniversityNational Engineering Research Center of Neuromodulation, School of Aerospace Engineering, Tsinghua UniversityDepartment of Neurosurgery, China International Neuroscience Institute (CHINA-INI), Xuanwu Hospital, Capital Medical UniversityNational Engineering Research Center of Neuromodulation, School of Aerospace Engineering, Tsinghua UniversityNational Engineering Research Center of Neuromodulation, School of Aerospace Engineering, Tsinghua UniversityNational Engineering Research Center of Neuromodulation, School of Aerospace Engineering, Tsinghua UniversityNational Engineering Research Center of Neuromodulation, School of Aerospace Engineering, Tsinghua UniversityNational Engineering Research Center of Neuromodulation, School of Aerospace Engineering, Tsinghua UniversityAbstract Neural electrode interfaces are essential to the stimulation safety and recording quality of various bioelectronic therapies. The recently proposed hierarchical platinum-iridium (Pt-Ir) electrodes produced by femtosecond lasers have exhibited superior electrochemical performance in vitro, but their in vivo performance is still unclear. In this study, we explored the electrochemical performance, biological response, and tissue adhesion of hierarchical Pt-Ir electrodes by implantation in adult rat brains for 1, 8, and 16 weeks. Regular smooth Pt-Ir electrodes were used as a control. The results showed that the electrochemical performance of both electrodes decreased and leveled off during implantation. However, after 16 weeks, the charge storage capacity of hierarchical electrodes stabilized at ~16.8 mC/cm2, which was 15 times that of the smooth control electrodes (1.1 mC/cm2). Moreover, the highly structured electrodes had lower impedance amplitude and cutoff frequency values. The similar histological response to smooth electrodes indicated good biocompatibility of the hierarchically structured Pt-Ir electrodes. Given their superior in vivo performance, the femtosecond laser-treated Pt-Ir electrode showed great potential for neuromodulation applications.https://doi.org/10.1038/s41378-022-00433-8 |
| spellingShingle | Linze Li Changqing Jiang Wanru Duan Zhiyan Wang Feng Zhang Changgeng He Tiangang Long Luming Li Electrochemical and biological performance of hierarchical platinum-iridium electrodes structured by a femtosecond laser Microsystems & Nanoengineering |
| title | Electrochemical and biological performance of hierarchical platinum-iridium electrodes structured by a femtosecond laser |
| title_full | Electrochemical and biological performance of hierarchical platinum-iridium electrodes structured by a femtosecond laser |
| title_fullStr | Electrochemical and biological performance of hierarchical platinum-iridium electrodes structured by a femtosecond laser |
| title_full_unstemmed | Electrochemical and biological performance of hierarchical platinum-iridium electrodes structured by a femtosecond laser |
| title_short | Electrochemical and biological performance of hierarchical platinum-iridium electrodes structured by a femtosecond laser |
| title_sort | electrochemical and biological performance of hierarchical platinum iridium electrodes structured by a femtosecond laser |
| url | https://doi.org/10.1038/s41378-022-00433-8 |
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