Bisphosphonate-incorporated coatings for orthopedic implants functionalization
Bisphosphonates (BPs), the stable analogs of pyrophosphate, are well-known inhibitors of osteoclastogenesis to prevent osteoporotic bone loss and improve implant osseointegration in patients suffering from osteoporosis. Compared to systemic administration, BPs-incorporated coatings enable the direct...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-10-01
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| Series: | Materials Today Bio |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006423001977 |
| _version_ | 1797682469238996992 |
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| author | Jiaxin Zhang Haotian Bai Miao Bai Xiaonan Wang ZuHao Li Haowen Xue Jincheng Wang Yutao Cui Hui Wang Yanbing Wang Rongqi Zhou Xiujie Zhu Mingwei Xu Xin Zhao He Liu |
| author_facet | Jiaxin Zhang Haotian Bai Miao Bai Xiaonan Wang ZuHao Li Haowen Xue Jincheng Wang Yutao Cui Hui Wang Yanbing Wang Rongqi Zhou Xiujie Zhu Mingwei Xu Xin Zhao He Liu |
| author_sort | Jiaxin Zhang |
| collection | DOAJ |
| description | Bisphosphonates (BPs), the stable analogs of pyrophosphate, are well-known inhibitors of osteoclastogenesis to prevent osteoporotic bone loss and improve implant osseointegration in patients suffering from osteoporosis. Compared to systemic administration, BPs-incorporated coatings enable the direct delivery of BPs to the local area, which will precisely enhance osseointegration and bone repair without the systemic side effects. However, an elaborate and comprehensive review of BP coatings of implants is lacking. Herein, the cellular level (e.g., osteoclasts, osteocytes, osteoblasts, osteoclast precursors, and bone mesenchymal stem cells) and molecular biological regulatory mechanism of BPs in regulating bone homeostasis are overviewed systematically. Moreover, the currently available methods (e.g., chemical reaction, porous carriers, and organic material films) of BP coatings construction are outlined and summarized in detail. As one of the key directions, the latest advances of BP-coated implants to enhance bone repair and osseointegration in basic experiments and clinical trials are presented and critically evaluated. Finally, the challenges and prospects of BP coatings are also purposed, and it will open a new chapter in clinical translation for BP-coated implants. |
| first_indexed | 2024-03-12T00:01:07Z |
| format | Article |
| id | doaj.art-75f67a4f195346c3bd802d44e6629bfb |
| institution | Directory Open Access Journal |
| issn | 2590-0064 |
| language | English |
| last_indexed | 2024-03-12T00:01:07Z |
| publishDate | 2023-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj.art-75f67a4f195346c3bd802d44e6629bfb2023-09-18T04:30:14ZengElsevierMaterials Today Bio2590-00642023-10-0122100737Bisphosphonate-incorporated coatings for orthopedic implants functionalizationJiaxin Zhang0Haotian Bai1Miao Bai2Xiaonan Wang3ZuHao Li4Haowen Xue5Jincheng Wang6Yutao Cui7Hui Wang8Yanbing Wang9Rongqi Zhou10Xiujie Zhu11Mingwei Xu12Xin Zhao13He Liu14Orthopedic Institute of Jilin Province, Orthopedic Medical Center, The Second Hospital of Jilin University, Changchun 130041, PR ChinaOrthopedic Institute of Jilin Province, Orthopedic Medical Center, The Second Hospital of Jilin University, Changchun 130041, PR ChinaDepartment of Ocular Fundus Disease, Ophthalmology Center, The Second Hospital of Jilin University, Changchun 130041, PR ChinaOrthopedic Institute of Jilin Province, Orthopedic Medical Center, The Second Hospital of Jilin University, Changchun 130041, PR ChinaOrthopedic Institute of Jilin Province, Orthopedic Medical Center, The Second Hospital of Jilin University, Changchun 130041, PR ChinaOrthopedic Institute of Jilin Province, Orthopedic Medical Center, The Second Hospital of Jilin University, Changchun 130041, PR ChinaOrthopedic Institute of Jilin Province, Orthopedic Medical Center, The Second Hospital of Jilin University, Changchun 130041, PR ChinaOrthopedic Institute of Jilin Province, Orthopedic Medical Center, The Second Hospital of Jilin University, Changchun 130041, PR ChinaOrthopedic Institute of Jilin Province, Orthopedic Medical Center, The Second Hospital of Jilin University, Changchun 130041, PR ChinaOrthopedic Institute of Jilin Province, Orthopedic Medical Center, The Second Hospital of Jilin University, Changchun 130041, PR ChinaOrthopedic Institute of Jilin Province, Orthopedic Medical Center, The Second Hospital of Jilin University, Changchun 130041, PR ChinaOrthopedic Institute of Jilin Province, Orthopedic Medical Center, The Second Hospital of Jilin University, Changchun 130041, PR ChinaOrthopedic Institute of Jilin Province, Orthopedic Medical Center, The Second Hospital of Jilin University, Changchun 130041, PR ChinaOrthopedic Institute of Jilin Province, Orthopedic Medical Center, The Second Hospital of Jilin University, Changchun 130041, PR China; Corresponding author.Orthopedic Institute of Jilin Province, Orthopedic Medical Center, The Second Hospital of Jilin University, Changchun 130041, PR China; Corresponding author.Bisphosphonates (BPs), the stable analogs of pyrophosphate, are well-known inhibitors of osteoclastogenesis to prevent osteoporotic bone loss and improve implant osseointegration in patients suffering from osteoporosis. Compared to systemic administration, BPs-incorporated coatings enable the direct delivery of BPs to the local area, which will precisely enhance osseointegration and bone repair without the systemic side effects. However, an elaborate and comprehensive review of BP coatings of implants is lacking. Herein, the cellular level (e.g., osteoclasts, osteocytes, osteoblasts, osteoclast precursors, and bone mesenchymal stem cells) and molecular biological regulatory mechanism of BPs in regulating bone homeostasis are overviewed systematically. Moreover, the currently available methods (e.g., chemical reaction, porous carriers, and organic material films) of BP coatings construction are outlined and summarized in detail. As one of the key directions, the latest advances of BP-coated implants to enhance bone repair and osseointegration in basic experiments and clinical trials are presented and critically evaluated. Finally, the challenges and prospects of BP coatings are also purposed, and it will open a new chapter in clinical translation for BP-coated implants.http://www.sciencedirect.com/science/article/pii/S2590006423001977BisphosphonatesFunctionalizationImplants coatingMolecular biological mechanismOsteointegration |
| spellingShingle | Jiaxin Zhang Haotian Bai Miao Bai Xiaonan Wang ZuHao Li Haowen Xue Jincheng Wang Yutao Cui Hui Wang Yanbing Wang Rongqi Zhou Xiujie Zhu Mingwei Xu Xin Zhao He Liu Bisphosphonate-incorporated coatings for orthopedic implants functionalization Materials Today Bio Bisphosphonates Functionalization Implants coating Molecular biological mechanism Osteointegration |
| title | Bisphosphonate-incorporated coatings for orthopedic implants functionalization |
| title_full | Bisphosphonate-incorporated coatings for orthopedic implants functionalization |
| title_fullStr | Bisphosphonate-incorporated coatings for orthopedic implants functionalization |
| title_full_unstemmed | Bisphosphonate-incorporated coatings for orthopedic implants functionalization |
| title_short | Bisphosphonate-incorporated coatings for orthopedic implants functionalization |
| title_sort | bisphosphonate incorporated coatings for orthopedic implants functionalization |
| topic | Bisphosphonates Functionalization Implants coating Molecular biological mechanism Osteointegration |
| url | http://www.sciencedirect.com/science/article/pii/S2590006423001977 |
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