Discharge Outcomes of Severely Sick Patients Hospitalized with Multidrug-Resistant Tuberculosis, Comorbidities, and Serious Adverse Events in Kyrgyz Republic, 2020–2022
Patients with multidrug-resistant tuberculosis (MDR-TB) who have comorbidities, complications, and experience serious adverse events (SAEs) are at substantial risk of having unfavorable hospital outcomes. We assessed characteristics and discharge outcomes of 138 MDR-TB patients hospitalized in the N...
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MDPI AG
2023-06-01
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author | Gulzat Alumkulova Anna Hazoyan Elena Zhdanova Yuliia Kuznetsova Jaya Prasad Tripathy Aelita Sargsyan Olga Goncharova Meder Kadyrov Kylychbek Istamov Nimer Ortuño-Gutiérrez |
author_facet | Gulzat Alumkulova Anna Hazoyan Elena Zhdanova Yuliia Kuznetsova Jaya Prasad Tripathy Aelita Sargsyan Olga Goncharova Meder Kadyrov Kylychbek Istamov Nimer Ortuño-Gutiérrez |
author_sort | Gulzat Alumkulova |
collection | DOAJ |
description | Patients with multidrug-resistant tuberculosis (MDR-TB) who have comorbidities, complications, and experience serious adverse events (SAEs) are at substantial risk of having unfavorable hospital outcomes. We assessed characteristics and discharge outcomes of 138 MDR-TB patients hospitalized in the National Referral Center of Bishkek, Kyrgyz Republic, from January 2020 to August 2022. The main clinical characteristics included pulmonary complications (23%), malnutrition (33%), severe anemia (17%), diabetes mellitus (13%), viral hepatitis B and C (5%), and HIV infection (3%). Of those patients, 95% were successfully managed and discharged from hospital. Seven patients had unfavorable discharge outcomes (three patients died and four had a worsened clinical condition). Comorbidities (diabetes, and/or HIV), severe anemia, pulmonary complications, cardiovascular disorders, alcohol abuse, and SAEs were associated with unfavorable discharge outcomes. Sixty-five percent of the patients had SAEs, with electrolyte imbalance (25%), gastrointestinal disease (18%), hepatotoxicity (16%), and anemia (14%) being the most frequent. Successful resolution occurred in 91% of patients with SAEs. In summary, our study documented that sick patients who were hospitalized with MDR-TB were well managed and had good hospital discharge outcomes, despite the fact that they had comorbidities, complications, and SAEs. This information should assist in the referral and management of such patients in the future. |
first_indexed | 2024-03-11T00:35:16Z |
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id | doaj.art-75f71e39e9ae4ab58078f7b004552ddf |
institution | Directory Open Access Journal |
issn | 2414-6366 |
language | English |
last_indexed | 2024-03-11T00:35:16Z |
publishDate | 2023-06-01 |
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series | Tropical Medicine and Infectious Disease |
spelling | doaj.art-75f71e39e9ae4ab58078f7b004552ddf2023-11-18T21:38:49ZengMDPI AGTropical Medicine and Infectious Disease2414-63662023-06-018733810.3390/tropicalmed8070338Discharge Outcomes of Severely Sick Patients Hospitalized with Multidrug-Resistant Tuberculosis, Comorbidities, and Serious Adverse Events in Kyrgyz Republic, 2020–2022Gulzat Alumkulova0Anna Hazoyan1Elena Zhdanova2Yuliia Kuznetsova3Jaya Prasad Tripathy4Aelita Sargsyan5Olga Goncharova6Meder Kadyrov7Kylychbek Istamov8Nimer Ortuño-Gutiérrez9National Center for Tuberculosis, Bishkek 720020, KyrgyzstanTuberculosis Research and Prevention Centre (TBRPC), Yerevan 0014, ArmeniaNational Center for Tuberculosis, Bishkek 720020, KyrgyzstanAlliance for Public Health, 01601 Kyiv, UkraineAll India Institute of Medical Sciences, Nagpur 441108, IndiaTuberculosis Research and Prevention Centre (TBRPC), Yerevan 0014, ArmeniaNational Center for Tuberculosis, Bishkek 720020, KyrgyzstanNational Center for Tuberculosis, Bishkek 720020, KyrgyzstanSchool of Medicine, Osh State University, Osh City 723500, KyrgyzstanDamien Foundation, 1081 Brussels, BelgiumPatients with multidrug-resistant tuberculosis (MDR-TB) who have comorbidities, complications, and experience serious adverse events (SAEs) are at substantial risk of having unfavorable hospital outcomes. We assessed characteristics and discharge outcomes of 138 MDR-TB patients hospitalized in the National Referral Center of Bishkek, Kyrgyz Republic, from January 2020 to August 2022. The main clinical characteristics included pulmonary complications (23%), malnutrition (33%), severe anemia (17%), diabetes mellitus (13%), viral hepatitis B and C (5%), and HIV infection (3%). Of those patients, 95% were successfully managed and discharged from hospital. Seven patients had unfavorable discharge outcomes (three patients died and four had a worsened clinical condition). Comorbidities (diabetes, and/or HIV), severe anemia, pulmonary complications, cardiovascular disorders, alcohol abuse, and SAEs were associated with unfavorable discharge outcomes. Sixty-five percent of the patients had SAEs, with electrolyte imbalance (25%), gastrointestinal disease (18%), hepatotoxicity (16%), and anemia (14%) being the most frequent. Successful resolution occurred in 91% of patients with SAEs. In summary, our study documented that sick patients who were hospitalized with MDR-TB were well managed and had good hospital discharge outcomes, despite the fact that they had comorbidities, complications, and SAEs. This information should assist in the referral and management of such patients in the future.https://www.mdpi.com/2414-6366/8/7/338SORT-ITpatient dischargeHIV infectionstuberculosismultidrug-resistantdiabetes mellitus |
spellingShingle | Gulzat Alumkulova Anna Hazoyan Elena Zhdanova Yuliia Kuznetsova Jaya Prasad Tripathy Aelita Sargsyan Olga Goncharova Meder Kadyrov Kylychbek Istamov Nimer Ortuño-Gutiérrez Discharge Outcomes of Severely Sick Patients Hospitalized with Multidrug-Resistant Tuberculosis, Comorbidities, and Serious Adverse Events in Kyrgyz Republic, 2020–2022 Tropical Medicine and Infectious Disease SORT-IT patient discharge HIV infections tuberculosis multidrug-resistant diabetes mellitus |
title | Discharge Outcomes of Severely Sick Patients Hospitalized with Multidrug-Resistant Tuberculosis, Comorbidities, and Serious Adverse Events in Kyrgyz Republic, 2020–2022 |
title_full | Discharge Outcomes of Severely Sick Patients Hospitalized with Multidrug-Resistant Tuberculosis, Comorbidities, and Serious Adverse Events in Kyrgyz Republic, 2020–2022 |
title_fullStr | Discharge Outcomes of Severely Sick Patients Hospitalized with Multidrug-Resistant Tuberculosis, Comorbidities, and Serious Adverse Events in Kyrgyz Republic, 2020–2022 |
title_full_unstemmed | Discharge Outcomes of Severely Sick Patients Hospitalized with Multidrug-Resistant Tuberculosis, Comorbidities, and Serious Adverse Events in Kyrgyz Republic, 2020–2022 |
title_short | Discharge Outcomes of Severely Sick Patients Hospitalized with Multidrug-Resistant Tuberculosis, Comorbidities, and Serious Adverse Events in Kyrgyz Republic, 2020–2022 |
title_sort | discharge outcomes of severely sick patients hospitalized with multidrug resistant tuberculosis comorbidities and serious adverse events in kyrgyz republic 2020 2022 |
topic | SORT-IT patient discharge HIV infections tuberculosis multidrug-resistant diabetes mellitus |
url | https://www.mdpi.com/2414-6366/8/7/338 |
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