The role of the N-terminal segment of CCR5 in HIV-1 Env-mediated membrane fusion and the mechanism of virus adaptation to CCR5 lacking this segment

The role of the N-terminal segment of CCR5 in HIV-1 Env-mediated membrane fusion and the mechanism of virus adaptation to CCR5 lacking this segment

<p>Abstract</p> <p>Background</p> <p>HIV-1 envelope glycoprotein (Env) induces membrane fusion as a result of sequential binding to CD4 and chemokine receptors (CCR5 or CXCR4). The critical determinants of CCR5 coreceptor function are the N-terminal domain (Nt) and the...

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Bibliographic Details
Main Authors: Kabat David, Platt Emily J, Melikyan Gregory B
Format: Article
Language:English
Published: BMC 2007-08-01
Series:Retrovirology
Online Access:http://www.retrovirology.com/content/4/1/55

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