Quantification of Low Amounts of Zoledronic Acid by HPLC-ESI-MS Analysis: Method Development and Validation

Quantification of Low Amounts of Zoledronic Acid by HPLC-ESI-MS Analysis: Method Development and Validation

Zoledronic acid (ZA) is used in the treatment of various bone pathologies, but it forms complexes with calcium ions present in body fluids, decreasing ZA bioavailability. Thereby, the study first describes the identification of ZA-calcium complexes that form in calcium-rich environments, in order to...

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Bibliographic Details
Main Authors:	Anca-Roxana Petrovici, Mihaela Silion, Natalia Simionescu, Rami Kallala, Mariana Pinteala, Stelian S. Maier
Format:	Article
Language:	English
Published:	MDPI AG 2022-05-01
Series:	International Journal of Molecular Sciences
Subjects:	zoledronic acid (ZA) calcium sulfate hemihydrate solid inorganic matrix HPLC-ESI-MS analysis extracted ion chromatogram (EIC) ZA-calcium complexes
Online Access:	https://www.mdpi.com/1422-0067/23/11/5944

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