DWI as a biomarker of renal function in children with CKD: what is the potential?
Abstract Background Evaluation of renal microstructure is pivotal for diagnosing and monitoring chronic renal disease. DWI has been proved to be practicable and reliable examination for the assessment of renal function and parenchymal damage in some renal diseases. Our aim is to appraise DWI sequenc...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2020-08-01
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| Series: | The Egyptian Journal of Radiology and Nuclear Medicine |
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| Online Access: | http://link.springer.com/article/10.1186/s43055-020-00277-0 |
| _version_ | 1828764097295941632 |
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| author | Sally Emad-Eldin Sunil Yadav Rasha Essam Eldin Galal Wessam Abdelrahman Elzayat |
| author_facet | Sally Emad-Eldin Sunil Yadav Rasha Essam Eldin Galal Wessam Abdelrahman Elzayat |
| author_sort | Sally Emad-Eldin |
| collection | DOAJ |
| description | Abstract Background Evaluation of renal microstructure is pivotal for diagnosing and monitoring chronic renal disease. DWI has been proved to be practicable and reliable examination for the assessment of renal function and parenchymal damage in some renal diseases. Our aim is to appraise DWI sequence and ADC measurement as a potential tool of renal function assessment as well as establishing a possible relationship between the different CKD stages and the renal parenchymal ADC values changes. Results Regarding the cause of CKD, nine patients (45%) had glomerulonephritis, 5 patients (25%) had hemolytic uremic syndrome, 2 patients (10%) had lupus nephritis, 2 patients (10%) had nepheronophthisis, and 1 patient (1.5%) had infantile nepherosis, whereas the cause of CKD was unknown in 1 patient (1.5%). The stages of CKD were classified according to KIDGO guidelines: 6 patients (30%) were stage 1, 4 patients (20%) were stage 2, 3 patients (15%) were stage 3, 2 patients (10%) were stage 4, and 5 patients (25%) were stage 5. The patients’ group (group A) had a mean ADC value (1.85 × 10−3 ± 0.24) which was significantly lower than that of the control group (group B) (2.21 × 10−3 ± 0.12). As for the correlation between stage of CKD and ADC, we found it to be a moderate negative one with r’ value of − .655 and a significant p value of < 0.001. Conclusion DWI is recognized as a promising imaging tool that can take part in the assessment of the morphological and functional changes in diffuse renal parenchymal disease, hence playing an important role in the early diagnosis and staging of chronic kidney disease. |
| first_indexed | 2024-12-11T02:14:35Z |
| format | Article |
| id | doaj.art-75f8b2716cf44dbb9a9eb299a242009d |
| institution | Directory Open Access Journal |
| issn | 2090-4762 |
| language | English |
| last_indexed | 2024-12-11T02:14:35Z |
| publishDate | 2020-08-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Journal of Radiology and Nuclear Medicine |
| spelling | doaj.art-75f8b2716cf44dbb9a9eb299a242009d2022-12-22T01:24:12ZengSpringerOpenThe Egyptian Journal of Radiology and Nuclear Medicine2090-47622020-08-015111810.1186/s43055-020-00277-0DWI as a biomarker of renal function in children with CKD: what is the potential?Sally Emad-Eldin0Sunil Yadav1Rasha Essam Eldin Galal2Wessam Abdelrahman Elzayat3Diagnostic and Intervention Radiology Department, Cairo University Hospitals, Kasr Al-AinyDiagnostic and Intervention Radiology Department, Cairo University Hospitals, Kasr Al-AinyPediatric Department, Nephrology Unit, Cairo University Hospitals, Kasr Al-AinyDiagnostic and Intervention Radiology Department, Cairo University Hospitals, Kasr Al-AinyAbstract Background Evaluation of renal microstructure is pivotal for diagnosing and monitoring chronic renal disease. DWI has been proved to be practicable and reliable examination for the assessment of renal function and parenchymal damage in some renal diseases. Our aim is to appraise DWI sequence and ADC measurement as a potential tool of renal function assessment as well as establishing a possible relationship between the different CKD stages and the renal parenchymal ADC values changes. Results Regarding the cause of CKD, nine patients (45%) had glomerulonephritis, 5 patients (25%) had hemolytic uremic syndrome, 2 patients (10%) had lupus nephritis, 2 patients (10%) had nepheronophthisis, and 1 patient (1.5%) had infantile nepherosis, whereas the cause of CKD was unknown in 1 patient (1.5%). The stages of CKD were classified according to KIDGO guidelines: 6 patients (30%) were stage 1, 4 patients (20%) were stage 2, 3 patients (15%) were stage 3, 2 patients (10%) were stage 4, and 5 patients (25%) were stage 5. The patients’ group (group A) had a mean ADC value (1.85 × 10−3 ± 0.24) which was significantly lower than that of the control group (group B) (2.21 × 10−3 ± 0.12). As for the correlation between stage of CKD and ADC, we found it to be a moderate negative one with r’ value of − .655 and a significant p value of < 0.001. Conclusion DWI is recognized as a promising imaging tool that can take part in the assessment of the morphological and functional changes in diffuse renal parenchymal disease, hence playing an important role in the early diagnosis and staging of chronic kidney disease.http://link.springer.com/article/10.1186/s43055-020-00277-0DWIADCCKDChildrenRenal function |
| spellingShingle | Sally Emad-Eldin Sunil Yadav Rasha Essam Eldin Galal Wessam Abdelrahman Elzayat DWI as a biomarker of renal function in children with CKD: what is the potential? The Egyptian Journal of Radiology and Nuclear Medicine DWI ADC CKD Children Renal function |
| title | DWI as a biomarker of renal function in children with CKD: what is the potential? |
| title_full | DWI as a biomarker of renal function in children with CKD: what is the potential? |
| title_fullStr | DWI as a biomarker of renal function in children with CKD: what is the potential? |
| title_full_unstemmed | DWI as a biomarker of renal function in children with CKD: what is the potential? |
| title_short | DWI as a biomarker of renal function in children with CKD: what is the potential? |
| title_sort | dwi as a biomarker of renal function in children with ckd what is the potential |
| topic | DWI ADC CKD Children Renal function |
| url | http://link.springer.com/article/10.1186/s43055-020-00277-0 |
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