MiR-145 is upregulated in the retarded preimplantation embryos and modulates cholesterol levels in mice preimplantation embryos through targeting Abca1

MiR-145 is upregulated in the retarded preimplantation embryos and modulates cholesterol levels in mice preimplantation embryos through targeting Abca1

Abstract Background Preimplantation embryonic lethality is a driver of female infertility. Certain microRNAs (miRNAs) have previously been demonstrated to play important roles in the regulation of embryogenesis. Methods Normally developing blastocysts and arrested embryos were collected from patient...

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Bibliographic Details
Main Authors: Ou Jian, Ni MengXia, Xing Shiyu, Meng QingXia, Zou QinYan, Ding Jie, Wang Wei, Wan Jiaojiao, Li Hong, Huang Yining
Format: Article
Language:English
Published: BMC 2022-12-01
Series:Reproductive Biology and Endocrinology
Subjects:
Preimplantation embryonic lethality
ICSI
miR-145
Abca1
Cholesterol
Online Access:https://doi.org/10.1186/s12958-022-01044-8

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